(Q45065658)

9 December 2017

title

Characterization of the 12q15 MDM2 and 12q13-14 CDK4 amplicons and clinical correlations in osteosarcoma (English)

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9 December 2017

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7

Irene L Andrulis

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9 December 2017

author name string

Salvador Mejia-Guerrero

1

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9 December 2017

Michael Quejada

2

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9 December 2017

Nalan Gokgoz

3

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9 December 2017

Mona Gill

4

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9 December 2017

Robert K Parkes

5

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9 December 2017

Jay S Wunder

6

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9 December 2017

language of work or name

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1 June 2010

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Genes, Chromosomes and Cancer

9 December 2017

published in

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9 December 2017

volume

49

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9 December 2017

issue

6

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9 December 2017

page(s)

518-525

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A high-throughput loss-of-function screening identifies novel p53 regulators

9 December 2017

cites work

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Spectral karyotyping identifies recurrent complex rearrangements of chromosomes 8, 17, and 20 in osteosarcomas

21 January 2018

1 reference

7 January 2021

COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system

1 reference

7 January 2021

Separate amplified regions encompassing CDK4 and MDM2 in human sarcomas

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7 January 2021

Induction of p53 expression and function by estrogen in osteoblasts

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7 January 2021

Cellular mechanisms of tumour suppression by the retinoblastoma gene.

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7 January 2021

Comparative genomic hybridization analysis of human sarcomas: II. Identification of novel amplicons at 6p and 17p in osteosarcomas

1 reference

7 January 2021

Differentially amplified chromosome 12 sequences in low- and high-grade osteosarcoma

1 reference

7 January 2021

Comparison of p53 mutations in patients with localized osteosarcoma and metastatic osteosarcoma

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7 January 2021

Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins

1 reference

7 January 2021

Genomic profiling of bone and soft tissue tumors with supernumerary ring chromosomes using tiling resolution bacterial artificial chromosome microarrays

1 reference

7 January 2021

Evaluation of MDM2 and CDK4 amplification by real-time PCR on paraffin wax-embedded material: a potential tool for the diagnosis of atypical lipomatous tumours/well-differentiated liposarcomas

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7 January 2021

HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon.

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7 January 2021

Osteosarcoma: anatomic and histologic variants

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7 January 2021

MDM2 and CDK4 gene amplification in Ewing's sarcoma.

1 reference

7 January 2021

Regulators of G1 cyclin-dependent kinases and cancers

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7 January 2021

p53 and MDM2 alterations in osteosarcomas: correlation with clinicopathologic features and proliferative rate

1 reference

7 January 2021

Amplification and protein expression of chromosome 12q13-15 genes in osteosarcomas of the jaws

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7 January 2021

Genome-wide array comparative genomic hybridization analysis reveals distinct amplifications in osteosarcoma

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7 January 2021

Autoimmunity and hematologic malignancies: associations and mechanisms

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7 January 2021

Alterations of the p53, Rb and MDM2 genes in osteosarcoma

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7 January 2021

Rap1A and rap1B ras-family proteins are prominently expressed in the nucleus of squamous carcinomas: nuclear translocation of GTP-bound active form.

1 reference

7 January 2021

Amplification of CDK4 and MDM2 in malignant melanoma.

1 reference

7 January 2021

MDM2 gene amplification in bone and soft‐tissue tumors: Association with tumor progression in differentiated adipose‐tissue tumors

1 reference

7 January 2021

Amplification of a gene encoding a p53-associated protein in human sarcomas

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7 January 2021

Amplification pattern of 12q13-q15 genes (MDM2, CDK4, GLI) in urinary bladder cancer

1 reference

7 January 2021

DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage

1 reference

7 January 2021

DNA sequence copy number increase at 8q: a potential new prognostic marker in high-grade osteosarcoma

1 reference

7 January 2021

The presence of carboxypeptidase-M in tumour cells signifies epidermal growth factor receptor expression in lung adenocarcinomas: the coexistence predicts a poor prognosis regardless of EGFR levels

1 reference

7 January 2021

CDK4 gene amplification in osteosarcoma: reciprocal relationship with INK4A gene alterations and mapping of 12q13 amplicons

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7 January 2021

Complexity of 12q13-22 amplicon in liposarcoma: microsatellite repeat analysis

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7 January 2021

Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas

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7 January 2021

TP53Mutations and Outcome in Osteosarcoma: A Prospective, Multicenter Study

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7 January 2021

COPS3 amplification and clinical outcome in osteosarcoma

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7 January 2021

Identifiers

DOI

10.1002/GCC.20761

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9 December 2017

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