(Q45228186)

11 December 2017

title

Development of an activity-based probe and in silico design reveal highly selective inhibitors for diacylglycerol lipase-α in brain (English)

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11 December 2017

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Sascha Hoogendoorn

6

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Freek J Janssen

Freek J Janssen

2

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Ross McGuire

Ross McGuire

7

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Bogdan I Florea

Bogdan I Florea

8

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Herman S Overkleeft

Herman S Overkleeft

14

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Marc P Baggelaar

Marc P Baggelaar

1

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author name string

Annelot C M van Esbroeck

3

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11 December 2017

Hans den Dulk

4

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11 December 2017

Marco Allarà

5

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11 December 2017

Nico Meeuwenoord

9

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11 December 2017

Hans van den Elst

10

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11 December 2017

Gijsbert A van der Marel

11

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11 December 2017

Jaap Brouwer

12

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11 December 2017

Vincenzo Di Marzo

13

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11 December 2017

Mario van der Stelt

15

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11 December 2017

language of work or name

English

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publication date

31 October 2013

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Angewandte Chemie International Edition

11 December 2017

published in

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volume

52

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11 December 2017

issue

46

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11 December 2017

page(s)

12081-12085

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Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain

11 December 2017

cites work

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201306295

The diacylglycerol lipases: structure, regulation and roles in and beyond endocannabinoid signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201306295

Multiple functions of endocannabinoid signaling in the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201306295

Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201306295

Synthesis and pharmacological activity of a potent inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201306295

Development of the first potent and specific inhibitors of endocannabinoid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201306295

Assay and inhibition of diacylglycerol lipase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201306295

Tetrahydrolipstatin analogues as modulators of endocannabinoid 2-arachidonoylglycerol metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201306295

DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201306295

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201306295

A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201306295

How chemoproteomics can enable drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201306295

The metabolic serine hydrolases and their functions in mammalian physiology and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201306295

Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201306295

Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201306295

Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201306295

Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201306295

Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201306295

alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201306295

Discovering potent and selective reversible inhibitors of enzymes in complex proteomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201306295

Molecular characterization and identification of surrogate substrates for diacylglycerol lipase α.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201306295

Development of highly potent inhibitors of the Ras-targeting human acyl protein thioesterases based on substrate similarity design

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201306295

Small-molecule inhibition of APT1 affects Ras localization and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201306295

Beta-lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201306295

Activity-based proteome profiling of potential cellular targets of Orlistat--an FDA-approved drug with anti-tumor activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201306295

Azido-BODIPY acid reveals quantitative Staudinger-Bertozzi ligation in two-step activity-based proteasome profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201306295

Identification of Acyl Protein Thioesterases 1 and 2 as the Cellular Targets of the Ras-Signaling Modulators Palmostatin B and M

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201306295

21 January 2018

Identifiers

DOI

10.1002/ANIE.201306295

1 reference

11 December 2017

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