(Q45304764)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28986324%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

title

The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin (English)

1 reference

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1 April 2020

0 references

8

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1 April 2020

author name string

Bo Wang

1

1 reference

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1 April 2020

Li Zeng

2

1 reference

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1 April 2020

Sean A Merillat

3

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1 April 2020

Svetlana Fischer

4

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1 April 2020

Joseph Ochaba

5

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1 April 2020

Leslie M Thompson

6

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1 April 2020

Sami J Barmada

7

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1 April 2020

Henry L Paulson

9

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1 April 2020

publication date

3 October 2017

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1 April 2020

published in

Neurobiology of Disease

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1 April 2020

volume

109

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1 April 2020

issue

Pt A

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1 April 2020

page(s)

127-136

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describes a project that uses

1 April 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5973538/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Evidence for a preferential loss of enkephalin immunoreactivity in the external globus pallidus in low grade Huntington's disease using high resolution image analysis

1 reference

12 December 2020

Reduction in enkephalin and substance P messenger RNA in the striatum of early grade Huntington's disease: a detailed cellular in situ hybridization study

1 reference

12 December 2020

PET study of the pre- and post-synaptic dopaminergic markers for the neurodegenerative process in Huntington's disease

1 reference

12 December 2020

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

1 reference

12 December 2020

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

1 reference

12 December 2020

A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein.

1 reference

12 December 2020

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

1 reference

12 December 2020

Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition.

1 reference

12 December 2020

Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.

1 reference

12 December 2020

Degradation of the epstein-barr virus latent membrane protein 1 (LMP1) by the ubiquitin-proteasome pathway. Targeting via ubiquitination of the N-terminal residue

1 reference

12 December 2020

Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice

1 reference

12 December 2020

Glutamine repeats and neurodegeneration

1 reference

12 December 2020

N-Acetylaspartate and DARPP-32 levels decrease in the corpus striatum of Huntington's disease mice

1 reference

12 December 2020

Degradation of the E7 human papillomavirus oncoprotein by the ubiquitin-proteasome system: targeting via ubiquitination of the N-terminal residue

1 reference

12 December 2020

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

12 December 2020

Lysine-independent ubiquitination of Epstein-Barr virus LMP2A.

1 reference

12 December 2020

Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein

1 reference

12 December 2020

Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus

1 reference

12 December 2020

SUMO modification of Huntingtin and Huntington's disease pathology

1 reference

12 December 2020

Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach

1 reference

12 December 2020

Ubiquitin-Proteasome-mediated degradation of Id1 is modulated by MyoD.

1 reference

12 December 2020

N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome

1 reference

12 December 2020

The tumor suppressor protein p16(INK4a) and the human papillomavirus oncoprotein-58 E7 are naturally occurring lysine-less proteins that are degraded by the ubiquitin system. Direct evidence for ubiquitination at the N-terminal residue

1 reference

12 December 2020

N-terminal polyubiquitination and degradation of the Arf tumor suppressor

1 reference

12 December 2020

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

1 reference

12 December 2020

Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions

1 reference

12 December 2020

CHIP suppresses polyglutamine aggregation and toxicity in vitro and in vivo.

1 reference

12 December 2020

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

1 reference

12 December 2020

Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models

1 reference

12 December 2020

Longitudinal evaluation of the Hdh(CAG)150 knock-in murine model of Huntington's disease

1 reference

12 December 2020

E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages

1 reference

12 December 2020

Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic

1 reference

12 December 2020

Sensitive biochemical aggregate detection reveals aggregation onset before symptom development in cellular and murine models of Huntington's disease

1 reference

12 December 2020

Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice

1 reference

12 December 2020

Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease

1 reference

12 December 2020

Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment

1 reference

12 December 2020

Cytoplasmic mislocalization of TDP-43 is toxic to neurons and enhanced by a mutation associated with familial amyotrophic lateral sclerosis

1 reference

12 December 2020

Acute polyglutamine expression in inducible mouse model unravels ubiquitin/proteasome system impairment and permanent recovery attributable to aggregate formation.

1 reference

12 December 2020

Early autophagic response in a novel knock-in model of Huntington disease

1 reference

12 December 2020

Quantitative relationships between huntingtin levels, polyglutamine length, inclusion body formation, and neuronal death provide novel insight into huntington's disease molecular pathogenesis

1 reference

12 December 2020

K63-linked ubiquitination and neurodegeneration

1 reference

12 December 2020

Ubiquitin proteasome-dependent degradation of the transcriptional coactivator PGC-1{alpha} via the N-terminal pathway

1 reference

12 December 2020

Early alterations of autophagy in Huntington disease-like mice

1 reference

12 December 2020

Balancing act: deubiquitinating enzymes in the nervous system

1 reference

12 December 2020

Novel mechanism of Hsp70 chaperone-mediated prevention of polyglutamine aggregates in a cellular model of huntington disease

1 reference

12 December 2020

Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP

1 reference

12 December 2020

Identification of novel potentially toxic oligomers formed in vitro from mammalian-derived expanded huntingtin exon-1 protein

1 reference

12 December 2020

Dysregulation of dopamine receptor D2 as a sensitive measure for Huntington disease pathology in model mice

1 reference

12 December 2020

The Ubiquitin-Proteasome System in Huntington's Disease: Are Proteasomes Impaired, Initiators of Disease, or Coming to the Rescue?

1 reference

12 December 2020

Ube2W conjugates ubiquitin to α-amino groups of protein N-termini

1 reference

12 December 2020

The ubiquitin-conjugating enzyme (E2) Ube2w ubiquitinates the N terminus of substrates

1 reference

12 December 2020

SUMO-2 and PIAS1 modulate insoluble mutant huntingtin protein accumulation

1 reference

12 December 2020

Soluble forms of polyQ-expanded huntingtin rather than large aggregates cause endoplasmic reticulum stress

1 reference

12 December 2020

The de-ubiquitinating enzyme ataxin-3 does not modulate disease progression in a knock-in mouse model of Huntington disease

1 reference

12 December 2020

Differential ubiquitination and degradation of huntingtin fragments modulated by ubiquitin-protein ligase E3A.

1 reference

12 December 2020

Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.

1 reference

12 December 2020

Ubiquitin pathways in neurodegenerative disease

1 reference

12 December 2020

Ubiquitination in disease pathogenesis and treatment

1 reference

12 December 2020

Intrinsic disorder drives N-terminal ubiquitination by Ube2w

1 reference

12 December 2020

Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1.

1 reference

12 December 2020

TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription.

1 reference

12 December 2020

Differential recruitment of UBQLN2 to nuclear inclusions in the polyglutamine diseases HD and SCA3.

1 reference

12 December 2020

Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21

1 reference

12 December 2020

Loss of the Ubiquitin-conjugating Enzyme UBE2W Results in Susceptibility to Early Postnatal Lethality and Defects in Skin, Immune, and Male Reproductive Systems

1 reference

12 December 2020

PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington's Disease-Associated Phenotypes In Vivo

1 reference

12 December 2020

Structure and Dynamics of the Huntingtin Exon-1 N-Terminus: A Solution NMR Perspective

1 reference

12 December 2020

10.1016/J.NBD.2017.10.002

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28986324%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

1 reference

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1 April 2020

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