(Q45390582)

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Oxidized Guanine Base Lesions Function in 8-Oxoguanine DNA Glycosylase-1-mediated Epigenetic Regulation of Nuclear Factor κB-driven Gene Expression.

scientific article published on 18 October 2016

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25 March 2020

Oxidized Guanine Base Lesions Function in 8-Oxoguanine DNA Glycosylase-1-mediated Epigenetic Regulation of Nuclear Factor κB-driven Gene Expression (English)

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25 March 2020

Spiros Vlahopoulos

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Muralidhar L. Hegde

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Allan R Brasier

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Journal of Biological Chemistry

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25553-25566

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Special AT-rich Sequence-binding Protein 1 (SATB1) Functions as an Accessory Factor in Base Excision Repair

1 reference

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Widespread transcriptional gene inactivation initiated by a repair intermediate of 8-oxoguanine

1 reference

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Transcription Factors and DNA Repair Enzymes Compete for Damaged Promoter Sites

1 reference

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Potential role of 8-oxoguanine DNA glycosylase 1 as a STAT1 coactivator in endotoxin-induced inflammatory response

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An oxidative DNA "damage" and repair mechanism localized in the VEGF promoter is important for hypoxia-induced VEGF mRNA expression.

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Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation

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24 May 2018

Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1).

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Inactivation of a common OGG1 variant by TNF-alpha in mammalian cells.

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Innate inflammation induced by the 8-oxoguanine DNA glycosylase-1-KRAS-NF-κB pathway

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The role of 8-oxoguanine DNA glycosylase-1 in inflammation

1 reference

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8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and α-smooth muscle actin polymerization.

1 reference

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8-oxoguanine DNA glycosylase-1 augments proinflammatory gene expression by facilitating the recruitment of site-specific transcription factors

1 reference

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DNA glycosylases search for and remove oxidized DNA bases

1 reference

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1 reference

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8-Oxoguanine DNA glycosylase-1 links DNA repair to cellular signaling via the activation of the small GTPase Rac1.

1 reference

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8-Oxoguanine DNA glycosylase (OGG1) deficiency increases susceptibility to obesity and metabolic dysfunction

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Down-regulation of 8-oxoguanine DNA glycosylase 1 expression in the airway epithelium ameliorates allergic lung inflammation

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Activation of ras signaling pathway by 8-oxoguanine DNA glycosylase bound to its excision product, 8-oxoguanine

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inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M116.751453

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Europe PubMed Central

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25 March 2020

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25 March 2020

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Europe PubMed Central

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25 March 2020

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