(Q45864768)

17 December 2017

title

A novel tetracycline-controlled transactivator-transrepressor system enables external control of oncolytic adenovirus replication (English)

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17 December 2017

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10

Hillen W

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17 December 2017

author name string

Fechner H

1

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17 December 2017

Wang X

2

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17 December 2017

Srour M

3

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17 December 2017

Siemetzki U

4

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17 December 2017

Seltmann H

5

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17 December 2017

Sutter AP

6

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17 December 2017

Scherübl H

7

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17 December 2017

Zouboulis CC

8

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17 December 2017

Schwaab R

9

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17 December 2017

Schultheiss HP

11

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17 December 2017

Poller W

12

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17 December 2017

publication date

1 September 2003

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17 December 2017

published in

Gene Therapy

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17 December 2017

volume

10

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17 December 2017

issue

19

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17 December 2017

page(s)

1680-1690

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17 December 2017

https://scigraph.springernature.com/pub.10.1038/sj.gt.3302051

exact match

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ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

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p53-dependent cell death/apoptosis is required for a productive adenovirus infection

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Tumor-specific, replication-competent adenovirus vectors overexpressing the adenovirus death protein

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Tissue-specific, tumor-selective, replication-competent adenovirus vector for cancer gene therapy

21 January 2018

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A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo.

21 January 2018

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Re-engineering adenovirus regulatory pathways to enhance oncolytic specificity and efficacy

21 January 2018

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Target gene therapy for alpha-fetoprotein-producing hepatocellular carcinoma by E1B55k-attenuated adenovirus

21 January 2018

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E1B-55K-deleted adenovirus expressing E1A-13S by AFP-enhancer/promoter is capable of highly specific replication in AFP-producing hepatocellular carcinoma and eradication of established tumor.

21 January 2018

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Selectivity of a replication-competent adenovirus for human breast carcinoma cells expressing the MUC1 antigen.

21 January 2018

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Adenoviral vectors with E1A regulated by tumor-specific promoters are selectively cytolytic for breast cancer and melanoma

21 January 2018

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A novel, conditionally replicative adenovirus for the treatment of breast cancer that allows controlled replication of E1a-deleted adenoviral vectors

21 January 2018

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New oncolytic adenoviruses with hypoxia- and estrogen receptor-regulated replication

21 January 2018

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Effective gene therapy for pancreatic cancer by cytokines mediated by restricted replication-competent adenovirus

21 January 2018

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Subcutaneous Administration of a Replication-Competent Adenovirus Expressing HSV-tk to Cotton Rats: Dissemination, Persistence, Shedding, and Pathogenicity

21 January 2018

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Does the antitumor adenovirus ONYX-015/dl1520 selectively target cells defective in the p53 pathway?

21 January 2018

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Replication and Interaction of Virus DNA and Cellular DNA in Mouse Cells Infected by a Human Adenovirus

21 January 2018

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A system for small-molecule control of conditionally replication-competent adenoviral vectors

21 January 2018

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Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity

21 January 2018

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Strict control of human immunodeficiency virus type 1 replication by a genetic switch: Tet for Tat.

21 January 2018

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A tetracycline controlled activation/repression system with increased potential for gene transfer into mammalian cells

21 January 2018

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The Krüppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression.

21 January 2018

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Tetracycline-reversible silencing of eukaryotic promoters

21 January 2018

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Tetracycline-regulatable factors with distinct dimerization domains allow reversible growth inhibition by p16.

21 January 2018

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Antitumoral effect of E1B defective adenoviruses in human malignant cells

21 January 2018

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Efficacy of a replication-competent adenovirus (ONYX-015) following intratumoral injection: intratumoral spread and distribution effects

21 January 2018

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Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: safety, feasibility and biological activity

21 January 2018

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Virus treatment questioned after gene therapy death

21 January 2018

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Multiple functional domains in the adenovirus E1A gene

21 January 2018

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Zinc finger and carboxyl regions of adenovirus E1A 13S CR3 are important for transactivation of the cytomegalovirus major immediate early promoter by adenovirus.

21 January 2018

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Double suicide gene therapy augments the antitumor activity of a replication-competent lytic adenovirus through enhanced cytotoxicity and radiosensitization

21 January 2018

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Persistent hepatic expression of human apo A-I after transfer with a helper-virus independent adenoviral vector

21 January 2018

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Tight control of gene expression by a helper-dependent adenovirus vector carrying the rtTA2(s)-M2 tetracycline transactivator and repressor system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302051

Trans-complementation of vector replication versus Coxsackie-adenovirus-receptor overexpression to improve transgene expression in poorly permissive cancer cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302051

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302051

'Autoreplication' of the vector genome in recombinant adenoviral vectors with different E1 region deletions and transgenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302051

Permanent cell line expressing human factor VIII-related antigen established by hybridization

21 January 2018

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Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302051

Expression of coxsackie adenovirus receptor and alphav-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302051

An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302051

7 January 2021

New tools for the construction of replication-competent adenoviral vectors with altered E1A regulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302051

7 January 2021

Conditional repression of the E2 transcription unit in E1-E3-deleted adenovirus vectors is correlated with a strong reduction in viral DNA replication and late gene expression in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302051

7 January 2021

The transactivation domain of adenovirus E1A interacts with the C terminus of human TAF(II)135.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302051

7 January 2021

Identifiers

DOI

10.1038/SJ.GT.3302051

1 reference

17 December 2017

Dimensions Publication ID

1049710369

0 references

1 reference

17 December 2017