(Q45882197)

17 December 2017

title

A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model (English)

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17 December 2017

main subject

hemophilia

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Coagulation factor VIII

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1 reference

32

Midori Shima

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17 December 2017

author name string

Takehisa Kitazawa

1

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17 December 2017

Tomoyuki Igawa

2

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17 December 2017

Zenjiro Sampei

3

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17 December 2017

Atsushi Muto

4

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17 December 2017

Tetsuo Kojima

5

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17 December 2017

Tetsuhiro Soeda

6

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17 December 2017

Kazutaka Yoshihashi

7

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17 December 2017

Yukiko Okuyama-Nishida

8

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17 December 2017

Hiroyuki Saito

9

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17 December 2017

Hiroyuki Tsunoda

10

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17 December 2017

Tsukasa Suzuki

11

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17 December 2017

Hideki Adachi

12

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17 December 2017

Taro Miyazaki

13

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17 December 2017

Shinya Ishii

14

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17 December 2017

Mika Kamata-Sakurai

15

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17 December 2017

Takeo Iida

16

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17 December 2017

Aya Harada

17

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17 December 2017

Keiko Esaki

18

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17 December 2017

Miho Funaki

19

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17 December 2017

Chifumi Moriyama

20

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17 December 2017

Eriko Tanaka

21

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17 December 2017

Yasufumi Kikuchi

22

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17 December 2017

Tetsuya Wakabayashi

23

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17 December 2017

Manabu Wada

24

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17 December 2017

Masaaki Goto

25

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17 December 2017

Takeshi Toyoda

26

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17 December 2017

Atsunori Ueyama

27

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17 December 2017

Sachiyo Suzuki

28

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17 December 2017

Kenta Haraya

29

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17 December 2017

Tatsuhiko Tachibana

30

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17 December 2017

Yoshiki Kawabe

31

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17 December 2017

Akira Yoshioka

33

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17 December 2017

Kunihiro Hattori

34

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17 December 2017

language of work or name

English

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publication date

30 September 2012

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17 December 2017

published in

Nature Medicine

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17 December 2017

volume

18

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17 December 2017

issue

10

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17 December 2017

page(s)

1570-1574

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17 December 2017

https://scigraph.springernature.com/pub.10.1038/nm.2942

exact match

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cites work

Validity of assessing inhibitor development in haemophilia PUPs using registry data: the EUHASS project

1 reference

Inhibitor development in correlation to factor VIII genotypes

21 January 2018

1 reference

21 January 2018

Modern haemophilia care

1 reference

Intravascular recovery of VWF and FVIII following intraperitoneal injection and differences from intravenous and subcutaneous injection in mice

21 January 2018

1 reference

Population pharmacokinetics of recombinant factor VIII: the relationships of pharmacokinetics to age and body weight

21 January 2018

1 reference

Venous access in haemophilic children: choice and management

21 January 2018

1 reference

Practice patterns in haemophilia A therapy -- global progress towards optimal care

21 January 2018

1 reference

Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia

21 January 2018

1 reference

Clinical severity of haemophilia A: does the classification of the 1950s still stand?

21 January 2018

1 reference

A randomized comparison of bypassing agents in hemophilia complicated by an inhibitor: the FEIBA NovoSeven Comparative (FENOC) Study

21 January 2018

1 reference

Anti-inhibitor coagulant complex prophylaxis in hemophilia with inhibitors

21 January 2018

1 reference

The principal results of the International Immune Tolerance Study: a randomized dose comparison

21 January 2018

1 reference

Survey of current prophylaxis practices and bleeding characteristics of children with severe haemophilia A in US haemophilia treatment centres

21 January 2018

1 reference

Activation of factor VIII and mechanisms of cofactor action

21 January 2018

1 reference

The A2 subunit of factor VIIIa modulates the active site of factor IXa.

21 January 2018

1 reference

A potent erythropoietin-mimicking human antibody interacts through a novel binding site

21 January 2018

1 reference

Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice

21 January 2018

1 reference

A fully human, allosteric monoclonal antibody that activates the insulin receptor and improves glycemic control

21 January 2018

1 reference

Strategies and challenges for the next generation of therapeutic antibodies

21 January 2018

1 reference

Development of a two-part strategy to identify a therapeutic human bispecific antibody that inhibits IgE receptor signaling

21 January 2018

1 reference

The tertiary structure and domain organization of coagulation factor VIII

21 January 2018

1 reference

Contrasting IgG Structures Reveal Extreme Asymmetry and Flexibility

21 January 2018

1 reference

Immunogenicity of protein therapeutics: The key causes, consequences and challenges

21 January 2018

1 reference

A novel one-armed anti-c-Met antibody inhibits glioblastoma growth in vivo

21 January 2018

1 reference

New assays for monitoring haemophilia treatment

21 January 2018

1 reference

Acquired hemophilia a: diagnosis, aetiology, clinical spectrum and treatment options

21 January 2018

1 reference

Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data: what have we learned?

21 January 2018

1 reference

Improvements in factor concentrates

21 January 2018

1 reference

Safety and prolonged activity of recombinant factor VIII Fc fusion protein in hemophilia A patients

21 January 2018

1 reference

Gene therapy for haemophilia: a long and winding road.

21 January 2018

1 reference

The immunogenicity of humanized and fully human antibodies: residual immunogenicity resides in the CDR regions

21 January 2018

1 reference

An efficient route to human bispecific IgG.

21 January 2018

1 reference

Engineering the variable region of therapeutic IgG antibodies.

21 January 2018

1 reference

Reduced elimination of IgG antibodies by engineering the variable region.

21 January 2018

1 reference

Intrachain disulfide bond in the core hinge region of human IgG4.

21 January 2018

1 reference

Usefulness of synthetic phospholipid in measurement of activated partial thromboplastin time: a new preparation procedure to reduce batch difference

21 January 2018

1 reference

Replacing the complementarity-determining regions in a human antibody with those from a mouse

21 January 2018

1 reference

Efficient production of recombinant human factor VIII by co-expression of the heavy and light chains

21 January 2018

1 reference

Calibrated automated thrombin generation measurement in clotting plasma

21 January 2018

1 reference

When should prophylaxis therapy in inhibitor patients be considered?

21 January 2018

1 reference

12 December 2020

Preclinical pharmacokinetics, interspecies scaling, and tissue distribution of a humanized monoclonal antibody against vascular endothelial growth factor.

1 reference

12 December 2020

BiTE: Teaching antibodies to engage T-cells for cancer therapy

1 reference

12 December 2020

A study of variations in the reported haemophilia A prevalence around the world

1 reference

12 December 2020

Identification of a binding site for blood coagulation factor IXa on the light chain of human factor VIII

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of a humanized monoclonal antibody to factor IX in cynomolgus monkeys

1 reference

12 December 2020

The cDNA and derived amino acid sequence of porcine factor VIII.

1 reference

12 December 2020

Localization of a factor X interactive site in the A1 subunit of factor VIIIa

1 reference

12 December 2020

Monoclonal antibody pharmacokinetics and pharmacodynamics

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12 December 2020

Identifiers

DOI

10.1038/NM.2942

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17 December 2017

Dimensions Publication ID

1046646584

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1 reference

17 December 2017