(Q46444487)

22 December 2017

title

Is DNA repair compromised in Alzheimer's disease? (English)

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22 December 2017

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Vladislav Davydov

1

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22 December 2017

Lawrence A Hansen

series ordinal

2

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22 December 2017

Deborah A Shackelford

series ordinal

3

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22 December 2017

publication date

1 November 2003

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22 December 2017

published in

Neurobiology of Aging

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22 December 2017

volume

24

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22 December 2017

issue

7

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22 December 2017

page(s)

953-968

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22 December 2017

DNA strand breaks in Alzheimer's disease.

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Oxidants, antioxidants, and the degenerative diseases of aging

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Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

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Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice

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DNA repair and Alzheimer's disease

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7 January 2021

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

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7 January 2021

Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death

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7 January 2021

Role of oxidants in ischemic brain damage

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7 January 2021

Role of DNA-dependent protein kinase in neuronal survival.

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7 January 2021

Hippocampal neurons of mice deficient in DNA-dependent protein kinase exhibit increased vulnerability to DNA damage, oxidative stress and excitotoxicity.

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7 January 2021

Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity.

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7 January 2021

DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

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7 January 2021

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

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7 January 2021

Going APE over ref-1.

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Ku, a DNA repair protein with multiple cellular functions?

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7 January 2021

The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations

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7 January 2021

DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair

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7 January 2021

Early decrease of apurinic/apyrimidinic endonuclease expression after transient focal cerebral ischemia in mice

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7 January 2021

Increased nuclear DNA oxidation in the brain in Alzheimer's disease.

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7 January 2021

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

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7 January 2021

Expression of nuclear redox factor ref-1 in the rat hippocampus following global ischemia induced by cardiac arrest.

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Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice

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7 January 2021

Poly(ADP-ribose) polymerase-1 in the nervous system

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7 January 2021

Loss of synaptophysin-like immunoreactivity in the hippocampal formation is an early phenomenon in Alzheimer's disease

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7 January 2021

Expression of DNA excision-repair-cross-complementing proteins p80 and p89 in brain of patients with Down Syndrome and Alzheimer's disease.

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7 January 2021

Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis

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7 January 2021

Transcription factor NF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease

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7 January 2021

The nonhomologous DNA end joining pathway is important for chromosome stability in primary fibroblasts

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7 January 2021

Early decrease in dna repair proteins, Ku70 and Ku86, and subsequent DNA fragmentation after transient focal cerebral ischemia in mice.

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7 January 2021

Ku autoantigen is a potential major cause of nonspecific bands in electrophoretic mobility shift assays

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7 January 2021

8OHdG levels in brain do not indicate oxidative DNA damage in Alzheimer's disease.

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7 January 2021

Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ

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https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900229-4

7 January 2021

Evidence for DNA-PK-dependent and -independent DNA double-strand break repair pathways in mammalian cells as a function of the cell cycle

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7 January 2021

Up-regulation of base excision repair activity for 8-hydroxy-2'-deoxyguanosine in the mouse brain after forebrain ischemia-reperfusion

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900229-4

7 January 2021

Increased DNA oxidation and decreased levels of repair products in Alzheimer's disease ventricular CSF.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900229-4

7 January 2021

Decreased base excision repair and increased helicase activity in Alzheimer's disease brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900229-4

7 January 2021

DNA damage distribution in the human brain as shown by in situ end labeling; area-specific differences in aging and Alzheimer disease in the absence of apoptotic morphology.

1 reference

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7 January 2021

Oxidative stress hypothesis in Alzheimer's disease

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7 January 2021

Increased immunoreactivity of brain spectrin in Alzheimer disease: a marker for synapse loss?

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7 January 2021

Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900229-4

7 January 2021

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900229-4

7 January 2021

DNA-PK, the DNA-activated protein kinase, is differentially expressed in normal and malignant human tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900229-4

7 January 2021

Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900229-4

7 January 2021

RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease.

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7 January 2021

Phosphorylation determines two distinct species of Tau in the central nervous system.

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7 January 2021

A suicide note from Alzheimer disease neurons?

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7 January 2021

Oxidative injury in diseases of the central nervous system: focus on Alzheimer's disease

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7 January 2021

Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900229-4

7 January 2021

Linking DNA damage and neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900229-4

7 January 2021

In situ immunodetection of neuronal caspase-3 activation in Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900229-4

7 January 2021

Changes in phosphorylation of tau during ischemia and reperfusion in the rabbit spinal cord.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900229-4

7 January 2021

Increased expression of DNA-dependent protein kinase confers resistance to adriamycin

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900229-4

7 January 2021

Evidence for apoptotic cell death in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900229-4

7 January 2021

The DNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900229-4

7 January 2021

Alzheimer disease: DNA fragmentation indicates increased neuronal vulnerability, but not apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900229-4

7 January 2021

Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900229-4

7 January 2021

Immunohistochemical evidence for apoptosis in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900229-4

7 January 2021

Activated caspase-3 expression in Alzheimer's and aged control brain: correlation with Alzheimer pathology.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900229-4

7 January 2021

Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900229-4

7 January 2021

Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

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https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900229-4

7 January 2021

Neocortical cell counts in normal human adult aging

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900229-4

7 January 2021

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900229-4

7 January 2021

Loss of Ref-1 protein expression precedes DNA fragmentation in apoptotic neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900229-4

7 January 2021

Simultaneous Degradation of αII- and βII-Spectrin by Caspase 3 (CPP32) in Apoptotic Cells

1 reference

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7 January 2021

The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest

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7 January 2021

Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1.

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7 January 2021

DNA replication precedes neuronal cell death in Alzheimer's disease.

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https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900229-4

7 January 2021

Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo

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https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900229-4

7 January 2021

10.1016/S0197-4580(02)00229-4

Identifiers

DOI

1 reference

22 December 2017

PubMed ID

12928056

1 reference

22 December 2017