(Q46467885)

22 December 2017

title

Caspase-2 cleavage of tau reversibly impairs memory (English)

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22 December 2017

8

Karen H Ashe

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22 December 2017

author name string

Xiaohui Zhao

1

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22 December 2017

Linda A Kotilinek

2

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22 December 2017

Benjamin Smith

3

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22 December 2017

Chris Hlynialuk

4

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22 December 2017

Kathleen Zahs

5

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22 December 2017

Martin Ramsden

6

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22 December 2017

James Cleary

7

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22 December 2017

language of work or name

English

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publication date

10 October 2016

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22 December 2017

published in

Nature Medicine

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22 December 2017

volume

22

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22 December 2017

page(s)

1268-1276

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22 December 2017

issue

11

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22 December 2017

https://scigraph.springernature.com/pub.10.1038/nm.4199

exact match

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cites work

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Differential regulation of dynein and kinesin motor proteins by tau

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Caspase activation precedes and leads to tangles

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Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs

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Pathological tau disrupts ongoing network activity.

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Tau suppression in a neurodegenerative mouse model improves memory function

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Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration

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Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines

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Tau phosphorylation and tau mislocalization mediate soluble Aβ oligomer-induced AMPA glutamate receptor signaling deficits.

21 January 2018

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The neuronal microtubule-associated protein tau is a substrate for caspase-3 and an effector of apoptosis

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Evidence for silent synapses: implications for the expression of LTP.

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Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice

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Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme

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A nonapoptotic role for CASP2/caspase 2: modulation of autophagy

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Caspase-2 protects against oxidative stress in vivo

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IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.

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Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice.

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Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease.

21 January 2018

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A caspase cleaved form of tau is preferentially degraded through the autophagy pathway

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A plasmonic chip for biomarker discovery and diagnosis of type 1 diabetes

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Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

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Effect size of memory deficits in mice with adult-onset P301L tau expression

21 January 2018

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21 January 2018

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A specific amyloid-beta protein assembly in the brain impairs memory

21 January 2018

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Noncanonical EF-hand motif strategically delays Ca2+ buffering to enhance cardiac performance

21 January 2018

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Clinical and pathological correlates of apolipoprotein E ?4 in Alzheimer's disease

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12 December 2020

C-terminal inhibition of tau assembly in vitro and in Alzheimer's disease.

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12 December 2020

The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.

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12 December 2020

Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome.

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12 December 2020

Characterization and use of monoclonal antibodies to tau and paired helical filament tau.

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Caspase-mediated truncation of tau potentiates aggregation

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12 December 2020

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.

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12 December 2020

Identifiers

DOI

10.1038/NM.4199

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22 December 2017

PubMed ID

27723722

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22 December 2017