(Q46602307)

23 December 2017

title

Development of benzophenone-based farnesyltransferase inhibitors as novel antimalarials (English)

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23 December 2017

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Katja Kohring

1

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23 December 2017

Jochen Wiesner

2

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23 December 2017

Mirko Altenkämper

3

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23 December 2017

Jacek Sakowski

4

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23 December 2017

Katrin Silber

5

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23 December 2017

Alexander Hillebrecht

6

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23 December 2017

Peter Haebel

7

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23 December 2017

Hans-Martin Dahse

8

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23 December 2017

Regina Ortmann

9

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23 December 2017

Hassan Jomaa

10

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23 December 2017

Gerhard Klebe

11

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23 December 2017

Martin Schlitzer

12

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23 December 2017

publication date

1 August 2008

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23 December 2017

published in

ChemMedChem

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23 December 2017

volume

3

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23 December 2017

issue

8

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23 December 2017

page(s)

1217-1231

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23 December 2017

Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique

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Ras-A Molecular Switch Involved in Tumor Formation

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Farnesyltransferase inhibitors: promises and realities

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Protein farnesyltransferase inhibitors

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Farnesyl transferase inhibitors in clinical development

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Farnesyltransferase inhibitors

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Inhibitors of farnesyltransferase: a rational approach to cancer chemotherapy?

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Protein prenylation: a pivotal posttranslational process

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Protein prenyl transferase activities of Plasmodium falciparum

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7 January 2021

Protein farnesyltransferase and protein prenylation in Plasmodium falciparum

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7 January 2021

Protein farnesyltransferase from Trypanosoma brucei. A heterodimer of 61- and 65-kda subunits as a new target for antiparasite therapeutics

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Cloning, heterologous expression, and distinct substrate specificity of protein farnesyltransferase from Trypanosoma brucei

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7 January 2021

The effects of protein farnesyltransferase inhibitors on trypanosomatids: inhibition of protein farnesylation and cell growth

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Cloning, heterologous expression, and substrate specificities of protein farnesyltransferases from Trypanosoma cruzi and Leishmania major

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7 January 2021

Identification and characterisation of Toxoplasma gondii protein farnesyltransferase

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7 January 2021

Molecular Cloning and Characterization of a Protein Farnesyltransferase from the Enteric Protozoan Parasite Entamoeba histolytica

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7 January 2021

The economic and social burden of malaria

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7 January 2021

Medical need, scientific opportunity and the drive for antimalarial drugs

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7 January 2021

Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue

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7 January 2021

Structure based design of benzophenone-based non-thiol farnesyltransferase inhibitors

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7 January 2021

Structure-activity relationships of novel anti-malarial agents. Part 4: N-(3-benzoyl-4-tolylacetylaminophenyl)-3-(5-aryl-2-furyl)acrylic acid amides

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7 January 2021

Structure-activity relationships of novel anti-malarial agents: part 5. N-(4-acylamino-3-benzoylphenyl)-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides

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7 January 2021

Structure-activity relationships of novel anti-malarial agents. Part 6: N-(4-arylpropionylamino-3-benzoylphenyl)-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides

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7 January 2021

Structure-activity relationships of novel anti-malarial agents. Part 7: N-(3-benzoyl-4-tolylacetylaminophenyl)-3-(5-aryl-2-furyl)acrylic acid amides with polar moieties

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7 January 2021

Farnesyltransferase inhibitors inhibit the growth of malaria parasites in vitro and in vivo

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7 January 2021

Amino acid substitutions that convert the protein substrate specificity of farnesyltransferase to that of geranylgeranyltransferase type I.

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7 January 2021

Human malaria parasites in continuous culture

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7 January 2021

Automated docking of substrates to proteins by simulated annealing

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7 January 2021

Distributed automated docking of flexible ligands to proteins: Parallel applications of AutoDock 2.4

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7 January 2021

The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003

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7 January 2021

T-Coffee: A novel method for fast and accurate multiple sequence alignment

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7 January 2021

Comparative protein structure modeling of genes and genomes

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7 January 2021

Limonene arrests parasite development and inhibits isoprenylation of proteins in Plasmodium falciparum.

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7 January 2021

Exploration of novel aryl binding sites of farnesyltransferase using molecular modeling and benzophenone-based farnesyltransferase inhibitors

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7 January 2021

Non-thiol farnesyltransferase inhibitors: N-(4-aminoacylamino-3-benzoylphenyl)-3-[5-(4-nitrophenyl)-2 furyl]acrylic acid amides and their antimalarial activity

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7 January 2021

Iterative partial equalization of orbital electronegativity—a rapid access to atomic charges

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7 January 2021

Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800043

7 January 2021

Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800043

7 January 2021

Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites

1 reference

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7 January 2021

Novel N-(4-Piperidinyl)benzamide antimalarials with mammalian protein farnesyltransferase inhibitory activity

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https://api.crossref.org/works/10.1002%2FCMDC.200800043

7 January 2021

Protein farnesyltransferase inhibitors exhibit potent antimalarial activity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800043

7 January 2021

Efficacy, Pharmacokinetics, and Metabolism of Tetrahydroquinoline Inhibitors of Plasmodium falciparum Protein Farnesyltransferase

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https://api.crossref.org/works/10.1002%2FCMDC.200800043

7 January 2021

2-Oxotetrahydroquinoline-based antimalarials with high potency and metabolic stability

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https://api.crossref.org/works/10.1002%2FCMDC.200800043

7 January 2021

Benzophenone-based farnesyltransferase inhibitors with high activity against Trypanosoma cruzi

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https://api.crossref.org/works/10.1002%2FCMDC.200800043

7 January 2021

Identifiers

DOI

10.1002/CMDC.200800043

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23 December 2017

1 reference

23 December 2017