(Q46706108)

24 December 2017

title

Identification of intestinal loss of a drug through physiologically based pharmacokinetic simulation of plasma concentration-time profiles (English)

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24 December 2017

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Sheila Annie Peters

1

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24 December 2017

publication date

1 January 2008

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24 December 2017

Clinical Pharmacokinetics

published in

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24 December 2017

volume

47

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24 December 2017

issue

4

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24 December 2017

page(s)

245-259

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24 December 2017

https://scigraph.springernature.com/pub.10.2165/00003088-200847040-00003

exact match

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cites work

Pharmacokinetics of (+)-, (-)- and (+/-)-verapamil after intravenous administration

1 reference

Crossref

https://api.crossref.org/works/10.2165%2F00003088-200847040-00003

Effects of calcium channel blockers on gastric emptying and acid secretion of the rat in vivo

21 January 2018

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Carboxyl nonsteroidal anti-inflammatory drugs are efficiently glucuronidated by microsomes of the human gastrointestinal tract.

21 January 2018

1 reference

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https://api.crossref.org/works/10.2165%2F00003088-200847040-00003

Caco-2 permeability of weakly basic drugs predicted with the double-sink PAMPA pKa(flux) method.

21 January 2018

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12 December 2020

Effects of verapamil and diltiazem on gastric emptying in normal subjects.

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12 December 2020

The pharmacology of verapamil. IV. Kinetic and dynamic effects after single intravenous and oral doses

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12 December 2020

What kinds of substrates show P-glycoprotein-dependent intestinal absorption? Comparison of verapamil with vinblastine

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12 December 2020

Glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid (TA-1801A) in humans: species differences in liver and intestinal microsomes

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12 December 2020

Effects of intestinal CYP3A4 and P-glycoprotein on oral drug absorption--theoretical approach

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12 December 2020

Functional interactions between P-glycoprotein and CYP3A in drug metabolism

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12 December 2020

Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach

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12 December 2020

The small intestine as a xenobiotic-metabolizing organ

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12 December 2020

Determination of in vivo absorption, metabolism, and transport of drugs by the human intestinal wall and liver with a novel perfusion technique.

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12 December 2020

Characterization of human small intestinal cytochromes P-450.

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12 December 2020

Use of in vitro drug metabolism data to evaluate metabolic drug-drug interactions in man: the need for quantitative databases

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12 December 2020

Physiologic modeling of cyclosporin kinetics in rat and man.

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12 December 2020

Early identification of drug-induced impairment of gastric emptying through physiologically based pharmacokinetic (PBPK) simulation of plasma concentration-time profiles in rat

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12 December 2020

Variable expression of CYP and Pgp genes in the human small intestine

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12 December 2020

Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of ezetimibe (Zetia).

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12 December 2020

Extrahepatic metabolism of drugs in humans

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12 December 2020

Impact of P-glycoprotein-mediated intestinal efflux kinetics on oral bioavailability of P-glycoprotein substrates

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12 December 2020

Comparative studies of drug-metabolizing enzymes in dog, monkey, and human small intestines, and in Caco-2 cells.

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12 December 2020

The role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism

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12 December 2020

Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection.

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12 December 2020

A kinetic evaluation of the absorption, efflux, and metabolism of verapamil in the autoperfused rat jejunum

1 reference

12 December 2020

Cytochrome P 450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues

1 reference

12 December 2020

Limited interaction between tacrolimus and P-glycoprotein in the rat small intestine

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12 December 2020

Limited role of P-glycoprotein in the intestinal absorption of cyclosporin A.

1 reference

12 December 2020

Differentiation of absorption and first-pass gut and hepatic metabolism in humans: Studies with cyclosporine*

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12 December 2020

Impact of concentration and rate of intraluminal drug delivery on absorption and gut wall metabolism of verapamil in humans

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12 December 2020

Cytochrome P450 3A4 and P-glycoprotein expression in human small intestinal enterocytes and hepatocytes: a comparative analysis in paired tissue specimens

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12 December 2020

[The effect of calcium antagonists and beta-adrenoblockaders on disordered stomach functions in patients with duodenal peptic ulcer]

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12 December 2020

Effect of verapamil on human intestinal transit

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12 December 2020

Innovative methods to study human intestinal drug metabolism in vitro: precision-cut slices compared with ussing chamber preparations.

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12 December 2020

The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein

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12 December 2020

Enantioselective tissue distribution of the basic drugs disopyramide, flecainide and verapamil in rats: role of plasma protein and tissue phosphatidylserine binding

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12 December 2020

Evaluation of a generic physiologically based pharmacokinetic model for lineshape analysis

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12 December 2020

Cardiovascular effects of (R)- and (S)-verapamil and racemic verapamil in humans: a placebo-controlled study

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12 December 2020

Is the role of the small intestine in first-pass metabolism overemphasized?

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12 December 2020

UDP-Glucuronosyltransferases

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12 December 2020

Development and application of physiologically based pharmacokinetic-modeling tools to support drug discovery.

1 reference

12 December 2020

Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine

1 reference

12 December 2020

Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism

1 reference

12 December 2020

Pharmacokinetics of the enantiomers of verapamil after intravenous and oral administration of racemic verapamil in a rat model

1 reference

12 December 2020

Tissue distribution of fentanyl and alfentanil in the rat cannot be described by a blood flow limited model.

1 reference

12 December 2020

Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines.

1 reference

12 December 2020

Permeability dominates in vivo intestinal absorption of P-gp substrate with high solubility and high permeability

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12 December 2020

Small Intestinal Cytochromes P450

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12 December 2020

Glucuronidation in vitro and in vivo. Comparison of intestinal and hepatic conjugation of morphine, naloxone, and buprenorphine

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12 December 2020

10.2165/00003088-200847040-00003

Identifiers

DOI

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24 December 2017

Dimensions Publication ID

1034207263

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24 December 2017