(Q46744858)

24 December 2017

title

DNA damage and nonhomologous end joining in excitotoxicity: neuroprotective role of DNA-PKcs in kainic acid-induced seizures (English)

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24 December 2017

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3

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24 December 2017

Janice R Naegele

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author name string

Mohit Neema

1

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24 December 2017

Ivan Navarro-Quiroga

2

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24 December 2017

Karen Gilliams-Francis

4

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24 December 2017

Jia Liu

5

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24 December 2017

Kristi Lamonica

6

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24 December 2017

Stanley L Lin

7

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24 December 2017

Janice R Naegele

8

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24 December 2017

publication date

1 January 2005

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24 December 2017

published in

Hippocampus

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24 December 2017

volume

15

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24 December 2017

issue

8

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24 December 2017

page(s)

1057-1071

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24 December 2017

DNA repair in neural cells: basic science and clinical implications

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Kainate, a double agent that generates seizures: two decades of progress

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Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures

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Involvement of the neuropeptide nociceptin/orphanin FQ in kainate seizures.

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Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination

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Kainic acid-induced excitotoxic hippocampal neurodegeneration in C57BL/6 mice: B cell and T cell subsets may contribute differently to the pathogenesis

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Glutamate neurotoxicity in cortical cell culture is calcium dependent

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7 January 2021

Regulation of class I MHC gene expression in the developing and mature CNS by neural activity

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7 January 2021

Neurotoxic action of kainic acid

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7 January 2021

DNA end-joining: from yeast to man

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7 January 2021

Hippocampal neurons of mice deficient in DNA-dependent protein kinase exhibit increased vulnerability to DNA damage, oxidative stress and excitotoxicity.

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7 January 2021

A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.

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7 January 2021

DNA strand breaks induced by sustained glutamate excitotoxicity in primary neuronal cultures.

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7 January 2021

An oral vaccine against NMDAR1 with efficacy in experimental stroke and epilepsy

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7 January 2021

Neurodegenerative diseases and oxidative stress

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7 January 2021

KA1-like kainate receptor subunit immunoreactivity in neurons and glia using a novel anti-peptide antibody.

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7 January 2021

Kainic acid-induced seizures produce necrotic, not apoptotic, neurons with internucleosomal DNA cleavage: implications for programmed cell death mechanisms.

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7 January 2021

A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination

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7 January 2021

Genetically engineered GABA-producing cells demonstrate anticonvulsant effects and long-term transgene expression when transplanted into the central piriform cortex of rats

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7 January 2021

Up-regulation of bax and down-regulation of bcl-2 is associated with kainate-induced apoptosis in mouse brain

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7 January 2021

PARP cleavage, DNA fragmentation, and pyknosis during excitotoxin-induced neuronal death.

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7 January 2021

Response of postmitotic neurons to X-irradiation: implications for the role of DNA damage in neuronal apoptosis.

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7 January 2021

Update on the glutamatergic neurotransmitter system and the role of excitotoxicity in amyotrophic lateral sclerosis

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https://api.crossref.org/works/10.1002%2FHIPO.20123

7 January 2021

Identification of major cell classes in the developing mammalian nervous system

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7 January 2021

Temporal progression of kainic acid induced neuronal and myelin degeneration in the rat forebrain

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7 January 2021

Repression of the human papillomavirus E6 gene initiates p53-dependent, telomerase-independent senescence and apoptosis in HeLa cervical carcinoma cells.

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7 January 2021

Neuronal stress and injury in C57/BL mice after systemic kainic acid administration.

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7 January 2021

Oxidative stress in Parkinson's disease

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7 January 2021

A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

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7 January 2021

Potentiality of DNA-dependent protein kinase to phosphorylate Ser46 of human p53.

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7 January 2021

Genetic correlations among inbred strain sensitivities to convulsions induced by 9 convulsant drugs.

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7 January 2021

Presynaptic kainate receptors in the hippocampus: slowly emerging from obscurity

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7 January 2021

Exacerbated status epilepticus and acute cell loss, but no changes in epileptogenesis, in mice with increased brain-derived neurotrophic factor signaling

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7 January 2021

Formation of the base modification 8-hydroxyl-2'-deoxyguanosine and DNA fragmentation following seizures induced by systemic kainic acid in the rat

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7 January 2021

Excitatory amino acids as a final common pathway for neurologic disorders.

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7 January 2021

Status epilepticus induces p53 sequence-specific DNA binding in mature rat brain.

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7 January 2021

Medial septum mediates the increase in post-ictal behaviors and hippocampal gamma waves after an electrically induced seizure.

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7 January 2021

The medial septum mediates impairment of prepulse inhibition of acoustic startle induced by a hippocampal seizure or phencyclidine

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7 January 2021

Oxidative stress, radiation-adaptive responses, and aging

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7 January 2021

Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity

1 reference

https://api.crossref.org/works/10.1002%2FHIPO.20123

7 January 2021

Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death.

1 reference

https://api.crossref.org/works/10.1002%2FHIPO.20123

7 January 2021

Minireview. Kainic acid as a tool for the study of temporal lobe epilepsy

1 reference

https://api.crossref.org/works/10.1002%2FHIPO.20123

7 January 2021

Oxidative damage and defective DNA repair is linked to apoptosis of migrating neurons and progenitors during cerebral cortex development in Ku70-deficient mice

1 reference

https://api.crossref.org/works/10.1002%2FHIPO.20123

7 January 2021

DNA damage-induced apoptosis

1 reference

https://api.crossref.org/works/10.1002%2FHIPO.20123

7 January 2021

The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition

1 reference

https://api.crossref.org/works/10.1002%2FHIPO.20123

7 January 2021

Self-sustaining status epilepticus after a brief electrical stimulation of the perforant path: a 2-deoxyglucose study.

1 reference

https://api.crossref.org/works/10.1002%2FHIPO.20123

7 January 2021

Histological and ultrastructural localization of the kainate receptor subunits, KA2 and GluR6/7, in the rat nervous system using selective antipeptide antibodies

1 reference

https://api.crossref.org/works/10.1002%2FHIPO.20123

7 January 2021

Immune surveillance in the injured nervous system: T-lymphocytes invade the axotomized mouse facial motor nucleus and aggregate around sites of neuronal degeneration.

1 reference

https://api.crossref.org/works/10.1002%2FHIPO.20123

7 January 2021

Kainate binding sites in the hippocampal mossy fibers: Localization and plasticity

1 reference

https://api.crossref.org/works/10.1002%2FHIPO.20123

7 January 2021

Effects of retroviral vector design on expression of human adenosine deaminase in murine bone marrow transplant recipients engrafted with genetically modified cells

1 reference

https://api.crossref.org/works/10.1002%2FHIPO.20123

7 January 2021

Glutamate and the pathophysiology of hypoxic--ischemic brain damage

1 reference

https://api.crossref.org/works/10.1002%2FHIPO.20123

7 January 2021

The epileptogenic effect of seizures induced by hypoxia: the role of NMDA and AMPA/KA antagonists

1 reference

https://api.crossref.org/works/10.1002%2FHIPO.20123

7 January 2021

Nuclear accumulation of p53 protein following kainic acid-induced seizures.

1 reference

https://api.crossref.org/works/10.1002%2FHIPO.20123

7 January 2021

Neuronal nuclear antigen (NeuN): a marker of neuronal maturation in early human fetal nervous system

1 reference

https://api.crossref.org/works/10.1002%2FHIPO.20123

7 January 2021

Spontaneous limbic seizures after intrahippocampal infusion of brain-derived neurotrophic factor.

1 reference

https://api.crossref.org/works/10.1002%2FHIPO.20123

7 January 2021

Genetic determinants of susceptibility to excitotoxic cell death: implications for gene targeting approaches

1 reference

https://api.crossref.org/works/10.1002%2FHIPO.20123

7 January 2021

Behavioural correlates of an altered balance between synaptic and extrasynaptic GABAAergic inhibition in a mouse model.

1 reference

https://api.crossref.org/works/10.1002%2FHIPO.20123

7 January 2021

Apoptosis and necrosis induced in different hippocampal neuron populations by repetitive perforant path stimulation in the rat.

1 reference

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7 January 2021

Age-dependent modulation of DNA repair enzymes by covalent modification and subcellular distribution

1 reference

https://api.crossref.org/works/10.1002%2FHIPO.20123

7 January 2021

Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity

1 reference

https://api.crossref.org/works/10.1002%2FHIPO.20123

7 January 2021

Calcium-mediated cell injury and cell death

1 reference

https://api.crossref.org/works/10.1002%2FHIPO.20123

7 January 2021

Neuroprotection and neurodegenerative disease

1 reference

https://api.crossref.org/works/10.1002%2FHIPO.20123

7 January 2021

Elevated DNA double strand breaks and apoptosis in the CNS of scid mutant mice.

1 reference

https://api.crossref.org/works/10.1002%2FHIPO.20123

7 January 2021

A complex mosaic of high-affinity kainate receptors in rat brain.

1 reference

https://api.crossref.org/works/10.1002%2FHIPO.20123

7 January 2021

Human DNA repair genes

1 reference

https://api.crossref.org/works/10.1002%2FHIPO.20123

7 January 2021

Increased dendritic excitability in hippocampal ca1 in vivo in the kainic acid model of temporal lobe epilepsy: a study using current source density analysis

1 reference

https://api.crossref.org/works/10.1002%2FHIPO.20123

7 January 2021

Role of endonuclease G in neuronal excitotoxicity in mice

1 reference

https://api.crossref.org/works/10.1002%2FHIPO.20123

7 January 2021

ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses.

1 reference

https://api.crossref.org/works/10.1002%2FHIPO.20123

7 January 2021

Apoptosis and genomic instability

1 reference

https://api.crossref.org/works/10.1002%2FHIPO.20123

7 January 2021

Identifiers

DOI

10.1002/HIPO.20123

1 reference

24 December 2017

PubMed ID

16216017

1 reference

24 December 2017