(Q35876010)

10 August 2017

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title

Apoptosis and genomic instability (English)

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10 August 2017

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2

Guido Kroemer

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Boris Zhivotovsky

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Boris Zhivotovsky

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1

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language of work or name

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1 September 2004

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Nature Reviews Molecular Cell Biology

10 August 2017

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10 August 2017

5

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10 August 2017

752-762

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10 August 2017

9

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https://scigraph.springernature.com/pub.10.1038/nrm1443

10 August 2017

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cites work

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Mutations and aneuploidy: co-conspirators in cancer?

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Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution

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Drug specific resistance to oxaliplatin is associated with apoptosis defect in a cellular model of colon carcinoma

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Analysis of genetic alterations, classified according to their DNA ploidy pattern, in the progression of colorectal adenomas and early colorectal carcinomas

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DNA damage-induced apoptosis

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Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro

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DNA damage tumor suppressor genes and genomic instability

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Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila

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Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

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Genomic instability in mice lacking histone H2AX

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Histone H2AX Phosphorylation as a Predictor of Radiosensitivity and Target for Radiotherapy

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Live or let die: the cell's response to p53

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Involvement of histone H1.2 in apoptosis induced by DNA double-strand breaks

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Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription

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Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

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p53 has a direct apoptogenic role at the mitochondria

31 March 2020

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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

31 March 2020

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Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

31 March 2020

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p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation

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Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3

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The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress

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Constitutive telomerase expression promotes mammary carcinomas in aging mice

31 March 2020

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Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

31 March 2020

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p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

31 March 2020

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TERT suppresses apoptotis at a premitochondrial step by a mechanism requiring reverse transcriptase activity and 14-3-3 protein-binding ability

31 March 2020

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Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDA-induced neurotoxicity.

31 March 2020

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From polyploidy to aneuploidy, genome instability and cancer

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Megakaryocyte polyploidization is associated with a functional gene amplification

31 March 2020

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Liver cell polyploidization: a pivotal role for binuclear hepatocytes

31 March 2020

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Characterization of the p53-dependent postmitotic checkpoint following spindle disruption

31 March 2020

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Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage

31 March 2020

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Acute ablation of survivin uncovers p53-dependent mitotic checkpoint functions and control of mitochondrial apoptosis.

31 March 2020

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Induction of polyploidy and apoptosis after exposure to high concentrations of the spindle poison nocodazole

31 March 2020

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Human immunodeficiency virus 1 envelope glycoprotein complex-induced apoptosis involves mammalian target of rapamycin/FKBP12-rapamycin-associated protein-mediated p53 phosphorylation

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Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

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The cellular geography of aurora kinases

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The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo.

31 March 2020

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Inactivation of p53 and the development of tetraploidy in the elastase-SV40 T antigen transgenic mouse pancreas

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The consequence of p53 overexpression for liver tumor development and the response of transformed murine hepatocytes to genotoxic agents.

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The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe

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If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells

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Cell death by mitotic catastrophe: a molecular definition

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Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy.

31 March 2020

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Chromosome segregation and cancer: cutting through the mystery

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Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability

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Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension

31 March 2020

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Rapid induction of mitochondrial events and caspase-independent apoptosis in Survivin-targeted melanoma cells

31 March 2020

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Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis

31 March 2020

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HBXIP functions as a cofactor of survivin in apoptosis suppression

31 March 2020

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Dissecting p53 tumor suppressor functions in vivo

31 March 2020

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Control of apoptosis by p53.

31 March 2020

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Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice

31 March 2020

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Deficiency of the cyclin kinase inhibitor p21(WAF-1/CIP-1) promotes apoptosis of activated/memory T cells and inhibits spontaneous systemic autoimmunity

31 March 2020

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Drosophila p53 preserves genomic stability by regulating cell death

31 March 2020

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Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death

31 March 2020

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Poly(ADP-ribose) polymerase-1-mediated cell death in astrocytes requires NAD+ depletion and mitochondrial permeability transition

31 March 2020

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hMutSalpha- and hMutLalpha-dependent phosphorylation of p53 in response to DNA methylator damage

31 March 2020

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Apoptotic signaling in response to a single type of DNA lesion, O(6)-methylguanine.

31 March 2020

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RecQ family helicases: roles as tumor suppressor proteins

31 March 2020

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Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks

31 March 2020

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Characterization of homologous recombination induced by replication inhibition in mammalian cells

31 March 2020

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p210 BCR/ABL kinase regulates nucleotide excision repair (NER) and resistance to UV radiation

31 March 2020

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BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance

31 March 2020

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BCR-ABL down-regulates the DNA repair protein DNA-PKcs

31 March 2020

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BCR/ABL regulates response to DNA damage: the role in resistance to genotoxic treatment and in genomic instability

31 March 2020

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An oncogenic tyrosine kinase inhibits DNA repair and DNA-damage-induced Bcl-xL deamidation in T cell transformation

31 March 2020

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

31 March 2020

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Mitochondria and apoptosis

31 March 2020

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Ways of dying: multiple pathways to apoptosis.

31 March 2020

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The mitochondrion in apoptosis: how Pandora's box opens

31 March 2020

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Death and anti-death: tumour resistance to apoptosis

31 March 2020

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THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

31 March 2020

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Telomeres shorten during ageing of human fibroblasts

31 March 2020

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Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53.

31 March 2020

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A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

31 March 2020

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Cell senescence and hypermitogenic arrest

31 March 2020

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Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion

31 March 2020

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Transplanted bone marrow regenerates liver by cell fusion

31 March 2020

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Cell fusion is the principal source of bone-marrow-derived hepatocytes

31 March 2020

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In vivo hybridisation of human tumour and normal hamster cells.

31 March 2020

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Enhanced lung colonization and tumorigenicity of fused cells isolated from primary MCA tumors

31 March 2020

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Cell fusion: a hidden enemy?

31 March 2020

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Primary cells suppress oncogene-dependent apoptosis

31 March 2020

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Tumour cell hybridization and metastasis revisited

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM1443

1 reference

10 August 2017

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PubMed ID

15340382