(Q46774097)

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7-Amino-3,4-dihydro-1H-quinolin-2-one, a compound similar to the substituted coumarins, inhibits α-carbonic anhydrases without hydrolysis of the lactam ring.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25672528%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

7-Amino-3,4-dihydro-1H-quinolin-2-one, a compound similar to the substituted coumarins, inhibits α-carbonic anhydrases without hydrolysis of the lactam ring (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25672528%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

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29 February 2020

4

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29 February 2020

Claudiu T Supuran

5

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Claudiu T Supuran

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29 February 2020

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Daniela Vullo

1

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29 February 2020

Semra Isik

2

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29 February 2020

publication date

12 February 2015

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29 February 2020

Journal of Enzyme Inhibition and Medicinal Chemistry

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25672528%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

30

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29 February 2020

5

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29 February 2020

773-777

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29 February 2020

Multiple binding modes of inhibitors to carbonic anhydrases: how to design specific drugs targeting 15 different isoforms?

1 reference

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21 January 2018

Structure-based drug discovery of carbonic anhydrase inhibitors

1 reference

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21 January 2018

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

1 reference

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Interfering with pH regulation in tumours as a therapeutic strategy

1 reference

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21 January 2018

Anticancer carbonic anhydrase inhibitors: a patent review (2008 - 2013).

1 reference

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21 January 2018

Root effect hemoglobin may have evolved to enhance general tissue oxygen delivery.

1 reference

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21 January 2018

Sulfa and trimethoprim-like drugs - antimetabolites acting as carbonic anhydrase, dihydropteroate synthase and dihydrofolate reductase inhibitors

1 reference

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21 January 2018

Carbonic anhydrase inhibitors

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Carbonic anhydrase III: a neglected isozyme is stepping into the limelight

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Exploiting the hydrophobic and hydrophilic binding sites for designing carbonic anhydrase inhibitors

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Inhibition of mammalian carbonic anhydrases I-XIV with grayanotoxin III: solution and in silico studies.

1 reference

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21 January 2018

Carbonic anhydrase inhibitors. Phenols incorporating 2- or 3-pyridyl-ethenylcarbonyl and tertiary amine moieties strongly inhibit Saccharomyces cerevisiae β-carbonic anhydrase.

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Carbonic anhydrase is an ancient enzyme widespread in prokaryotes

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms

1 reference

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21 January 2018

Bacterial carbonic anhydrases as drug targets: toward novel antibiotics?

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Carbonic anhydrase inhibitors

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Sulfonamides: a patent review (2008 - 2012).

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Carbonic anhydrase inhibitors: in vitro inhibition of α isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids.

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Novel therapies for glaucoma: a patent review 2007 - 2011.

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Antiglaucoma carbonic anhydrase inhibitors: a patent review

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Carbonic anhydrase inhibitors: an editorial.

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Diuretics with carbonic anhydrase inhibitory action: a patent and literature review (2005 - 2013).

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Antiobesity carbonic anhydrase inhibitors: a literature and patent review

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Anti-infective carbonic anhydrase inhibitors: a patent and literature review

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Biochemical properties of a new α-carbonic anhydrase from the human pathogenic bacterium, Vibrio cholerae

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

3D-QSAR CoMFA studies on sulfonamide inhibitors of the Rv3588c β-carbonic anhydrase from Mycobacterium tuberculosis and design of not yet synthesized new molecules

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Dithiocarbamates strongly inhibit the β-class carbonic anhydrases from Mycobacterium tuberculosis

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Synthesis of aminocyanopyrazoles via a multi-component reaction and anti-carbonic anhydrase inhibitory activity of their sulfamide derivatives against cytosolic and transmembrane isoforms.

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

More effective dithiocarbamate derivatives inhibiting carbonic anhydrases, generated by QSAR and computational design

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors.

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II.

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Novel coumarins and benzocoumarins acting as isoform-selective inhibitors against the tumor-associated carbonic anhydrase IX.

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Sulfocoumarins (1,2-benzoxathiine-2,2-dioxides): a class of potent and isoform-selective inhibitors of tumor-associated carbonic anhydrases

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

7-Substituted-sulfocoumarins are isoform-selective, potent carbonic anhydrase II inhibitors.

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis.

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

α-Carbonic anhydrases are sulfatases with cyclic diol monosulfate esters

1 reference

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21 January 2018

Inhibition of carbonic anhydrase activity modifies the toxicity of doxorubicin and melphalan in tumour cellsin vitro

1 reference

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21 January 2018

Inhibition of the alpha- and beta-carbonic anhydrases from the gastric pathogenHelycobacter pyloriwith anions

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Dihalogenated sulfanilamides and benzolamides are effective inhibitors of the three β-class carbonic anhydrases fromMycobacterium tuberculosis

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Novel coumarins and 2-thioxo-coumarins as inhibitors of the tumor-associated carbonic anhydrases IX and XII

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.970185

21 January 2018

Identifiers

10.3109/14756366.2014.970185

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25672528%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25672528%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

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