(Q47194598)

20 February 2018

title

Adult Human Primary Cardiomyocyte-Based Model for the Simultaneous Prediction of Drug-Induced Inotropic and Pro-arrhythmia Risk (English)

1 reference

20 February 2018

author name string

Nathalie Nguyen

1

1 reference

20 February 2018

William Nguyen

2

1 reference

20 February 2018

Brynna Nguyenton

3

1 reference

20 February 2018

Phachareeya Ratchada

4

1 reference

20 February 2018

Guy Page

5

1 reference

20 February 2018

Paul E Miller

6

1 reference

20 February 2018

Andre Ghetti

7

1 reference

20 February 2018

Najah Abi-Gerges

8

1 reference

20 February 2018

publication date

19 December 2017

1 reference

20 February 2018

published in

Frontiers in Physiology

1 reference

20 February 2018

volume

8

1 reference

20 February 2018

page(s)

1073

1 reference

20 February 2018

Creative Commons Attribution 4.0 International

copyright license

start time

19 December 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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23 May 2018

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23 May 2018

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Domperidone and ventricular arrhythmia or sudden cardiac death: a population-based case-control study in the Netherlands

23 May 2018

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Risk of serious ventricular arrhythmia and sudden cardiac death in a cohort of users of domperidone: a nested case-control study

23 May 2018

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23 May 2018

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23 May 2018

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23 May 2018

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23 May 2018

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23 May 2018

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Ranolazine shortens repolarization in patients with sustained inward sodium current due to type-3 long-QT syndrome

23 May 2018

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23 May 2018

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Ranolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium current

23 May 2018

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23 May 2018

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23 May 2018

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Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties

23 May 2018

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23 May 2018

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23 May 2018

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23 May 2018

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23 May 2018

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23 May 2018

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23 May 2018

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23 May 2018

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23 May 2018

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23 May 2018

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QT prolongation and Torsades de Pointes associated with clarithromycin

23 May 2018

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23 May 2018

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Effect of calcium channel block on the wall motion abnormality of the idiopathic long QT syndrome

23 May 2018

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Hemodynamic effects of mexiletine

23 May 2018

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23 May 2018

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23 May 2018

1 reference

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Incidence and clinical features of the quinidine-associated long QT syndrome: implications for patient care

23 May 2018

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23 May 2018

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Clinical safety profile of sotalol in patients with arrhythmias

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5742250

Unsuspected echocardiographic abnormality in the long QT syndrome. Diagnostic, prognostic, and pathogenetic implications.

23 May 2018

1 reference

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Hemodynamic effects of quinidine and famotidine in patients with congestive heart failure

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5742250

Dofetilide, a novel class III antiarrhythmic agent

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5742250

Quinidine-induced ventricular flutter and fibrillation without digitalis therapy

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5742250

Electrophysiological study of human ventricular heart muscle treated with quinidine: interaction with isoprenaline

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5742250

The Evolving Roles of Human iPSC-Derived Cardiomyocytes in Drug Safety and Discovery.

23 May 2018

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A new paradigm for drug-induced torsadogenic risk assessment using human iPS cell-derived cardiomyocytes.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5742250

Comprehensive Translational Assessment of Human-Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5742250

Human pluripotent stem cell-derived cardiomyocyte based models for cardiotoxicity and drug discovery.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5742250

The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative - Update on progress.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5742250

Evolution of strategies to improve preclinical cardiac safety testing

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5742250

Assessing drug safety in human tissues - what are the barriers?

14 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5742250

Proarrhythmia Risk Assessment in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Using the Maestro MEA Platform

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5742250

Differentiating drug-induced multichannel block on the electrocardiogram: randomized study of dofetilide, quinidine, ranolazine, and verapamil.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5742250

Rechanneling the cardiac proarrhythmia safety paradigm: a meeting report from the Cardiac Safety Research Consortium.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5742250

Preservation of cardiomyocytes from the adult heart

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5742250

Restricting excessive cardiac action potential and QT prolongation: a vital role for IKs in human ventricular muscle.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5742250

Tamoxifen inhibits Na+ and K+ currents in rat ventricular myocytes

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5742250

Comparative effects of clarithromycin on action potential and ionic currents from rabbit isolated atrial and ventricular myocytes

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5742250

Potassium channel down-regulation in heart failure

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5742250

Cell geometry and contractile abnormalities of myocytes from failing human left ventricle.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5742250

Structural remodeling of cardiac myocytes in patients with ischemic cardiomyopathy

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5742250

Transient outward current in human and rat ventricular myocytes

14 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.3389%2FFPHYS.2017.01073

Long QT syndrome, a purely electrical disease? Not anymore

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.3389%2FFPHYS.2017.01073

Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure

21 January 2018

1 reference

12 December 2020

Cardiodepressant effects of mexiletine in patients with severe left ventricular dysfunction

1 reference

12 December 2020

Low dose quinidine-mexiletine combination therapy versus quinidine monotherapy for treatment of ventricular arrhythmias

1 reference

12 December 2020

Mexiletine: long-term efficacy and hemodynamic actions in patients with ventricular arrhythmia

1 reference

12 December 2020

Mexiletine-quinidine combination: electrophysiologic correlates of a favorable antiarrhythmic interaction in humans

1 reference

12 December 2020

Sotalol-induced beta blockade in cardiac patients

1 reference

12 December 2020

Effects of oral mexiletine on left and right ventricular function

1 reference

12 December 2020

Positive and Negative Inotropic Effects of dl -Sotalol and d -Sotalol in Failing and Nonfailing Human Myocardium Under Physiological Experimental Conditions

1 reference

12 December 2020

Reduced Contraction and Altered Frequency Response of Isolated Ventricular Myocytes From Patients With Heart Failure

1 reference

12 December 2020

Transient outward current in human ventricular myocytes of subepicardial and subendocardial origin

1 reference

12 December 2020

Regional differences in current density and rate-dependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle

1 reference

12 December 2020

Beta-adrenoceptor function changes with age of subject in myocytes from non-failing human ventricle

1 reference

12 December 2020

The antiestrogen tamoxifen blocks the delayed rectifier potassium current, IKr, in rabbit ventricular myocytes

1 reference

12 December 2020

The sarcoplasmic reticulum and the Na+/Ca2+ exchanger both contribute to the Ca2+ transient of failing human ventricular myocytes

1 reference

12 December 2020

Delayed rectifier potassium current in undiseased human ventricular myocytes

1 reference

12 December 2020

Clarithromycin associated with torsades de pointes

1 reference

12 December 2020

Attenuation of the negative inotropic effects of metoprolol at short cycle lengths in humans: comparison with sotalol and verapamil

1 reference

12 December 2020

Abnormal left ventricular relaxation in patients with long QT syndrome

1 reference

12 December 2020

Organotypic slice culture from human adult ventricular myocardium

1 reference

12 December 2020

Human embryonic stem cell derived cardiac myocytes detect hERG-mediated repolarization effects, but not Nav1.5 induced depolarization delay

1 reference

12 December 2020

An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel

1 reference

12 December 2020

Identifiers

DOI

10.3389/FPHYS.2017.01073

1 reference

20 February 2018

PMC publication ID

5742250

1 reference

20 February 2018

PubMed publication ID

29311989

1 reference

20 February 2018