(Q47291933)

13 January 2018

review article

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title

The twilight of immunity: emerging concepts in aging of the immune system (English)

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13 January 2018

author

Janko Nikolich-Žugich

series ordinal

1

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13 January 2018

language of work or name

English

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publication date

14 December 2017

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13 January 2018

published in

Nature Immunology

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13 January 2018

volume

19

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13 January 2018

issue

1

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13 January 2018

page(s)

10-19

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13 January 2018

Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo

cites work

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

CpG-ODN but not other TLR-ligands restore the antitumor responses in old mice: the implications for vaccinations in the aged.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Aging of the T cell compartment in mice and humans: from no naive expectations to foggy memories

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Innate immunesenescence: underlying mechanisms and clinical relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Paradoxical changes in innate immunity in aging: recent progress and new directions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Glimpse of natural selection of long-lived T-cell clones in healthy life

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Neutrophil ageing and immunesenescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Aging of the innate immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Innate immunosenescence: effect of aging on cells and receptors of the innate immune system in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Age-dependent susceptibility to a viral disease due to decreased natural killer cell numbers and trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Ageing is associated with diminished apoptotic cell clearance in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Human Monocyte Subsets Are Transcriptionally and Functionally Altered in Aging in Response to Pattern Recognition Receptor Agonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Influence of ageing on Langerhans cell migration in mice: identification of a putative deficiency of epidermal interleukin-1beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Leukocyte function in the aging immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Aging Impairs the Ability of Conventional Dendritic Cells to Cross-Prime CD8+ T Cells upon Stimulation with a TLR7 Ligand.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Loss of Phagocytic and Antigen Cross-Presenting Capacity in Aging Dendritic Cells Is Associated with Mitochondrial Dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Cutting Edge: The Aging Immune System Reveals the Biological Impact of Direct Antigen Presentation on CD8 T Cell Responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Changes in primary lymphoid organs with aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Diversity and clonal selection in the human T-cell repertoire

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Evolution of the antigen-specific CD8+ TCR repertoire across the life span: evidence for clonal homogenization of the old TCR repertoire

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Functional and Homeostatic Impact of Age-Related Changes in Lymph Node Stroma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Immunosenescence: a problem of lymphopoiesis, homeostasis, microenvironment, and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

B cell maintenance and function in aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

The aged lymphoid tissue environment fails to support naïve T cell homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Defective CD8 T cell responses in aged mice are due to quantitative and qualitative changes in virus-specific precursors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Two separate defects affecting true naive or virtual memory T cell precursors combine to reduce naive T cell responses with aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Cutting edge: Central memory CD8 T cells in aged mice are virtual memory cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Enrichment of immediate-early 1 (m123/pp89) peptide-specific CD8 T cells in a pulmonary CD62L(lo) memory-effector cell pool during latent murine cytomegalovirus infection of the lungs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Genome-wide analysis reveals a highly diverse CD8 T cell response to murine cytomegalovirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

A constant companion: immune recognition and response to cytomegalovirus with aging and implications for immune fitness.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Reduced Ig class switch in aged mice correlates with decreased E47 and activation-induced cytidine deaminase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

The generation of memory B cells is maintained, but the antibody response is not, in the elderly after repeated influenza immunizations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Age-Dependent Cell Trafficking Defects in Draining Lymph Nodes Impair Adaptive Immunity and Control of West Nile Virus Infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

The immune response of aged mice to influenza: diminished T-cell proliferation, interleukin 2 production and cytotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Interleukin 2, but not other common gamma chain-binding cytokines, can reverse the defect in generation of CD4 effector T cells from naive T cells of aged mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Bim dictates naive CD4 T cell lifespan and the development of age-associated functional defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Key role of T cell defects in age-related vulnerability to West Nile virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Increased apoptosis, curtailed expansion and incomplete differentiation of CD8+ T cells combine to decrease clearance of L. monocytogenes in old mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to Chikungunya Virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Age-associated alterations in CD8α+ dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Aging increases cell-to-cell transcriptional variability upon immune stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

The chromatin accessibility signature of human immune aging stems from CD8+ T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Reversible senescence in human CD4+CD45RA+CD27- memory T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Associations of Heart Rate With Inflammatory Markers Are Modulated by Gender and Obesity in Older Adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

The immunology of fibrosis: innate and adaptive responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

NK and NKT cells in liver injury and fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Fibroblastic reticular cells: organization and regulation of the T lymphocyte life cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Structural and functional changes to lymph nodes in ageing mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Role of cell-intrinsic and environmental age-related changes in altered maintenance of murine T cells in lymphoid organs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+ T cells during aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Lipopolysaccharide-binding protein, a surrogate marker of microbial translocation, is associated with physical function in healthy older adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Microbial translocation is a cause of systemic immune activation in chronic HIV infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Normalizing the environment recapitulates adult human immune traits in laboratory mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Toll-like receptor 4 in glial inflammatory responses to air pollution in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Variation in the human immune system is largely driven by non-heritable influences

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

How does cytomegalovirus factor into diseases of aging and vaccine responses, and by what mechanisms?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

CMV infection of human sinusoidal endothelium regulates hepatic T cell recruitment and activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Cytomegalovirus infection impairs immune responses and accentuates T-cell pool changes observed in mice with aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Immune senescence: relative contributions of age and cytomegalovirus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Immune Protection against Virus Challenge in Aging Mice Is Not Affected by Latent Herpesviral Infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Herpesvirus latency confers symbiotic protection from bacterial infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Cytomegalovirus infection enhances the immune response to influenza.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Recent advances in CMV tropism, latency, and diagnosis during aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Geriatric Syndromes in Older HIV-Infected Adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Is HIV a model of accelerated or accentuated aging?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Overview of caloric restriction and ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Thymic rejuvenation and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

mTOR inhibition improves immune function in the elderly

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Aging reduces the functionality of anti-pneumococcal antibodies and the killing of Streptococcus pneumoniae by neutrophil phagocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

Correction: Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

7 January 2021

Age-associated defect in human TLR-1/2 function

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

7 January 2021

Longterm maintenance of human naive T cells through in situ homeostasis in lymphoid tissue sites

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

7 January 2021

Differential tyrosine phosphorylation of zeta chain dimers in mouse CD4 T lymphocytes: effect of age

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

7 January 2021

Epigenomics of human CD8 T cell differentiation and aging

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

7 January 2021

The origins of age-related proinflammatory state

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

7 January 2021

Increased cytokine production in mononuclear cells of healthy elderly people

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

7 January 2021

Chemokine Cxcl9 attenuates liver fibrosis-associated angiogenesis in mice

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

7 January 2021

Influences of microbiota on intestinal immune system development

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

7 January 2021

Recent immune status determines the source of antigens that drive homeostatic T cell expansion

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

7 January 2021

Gut microbiota composition correlates with diet and health in the elderly

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

7 January 2021

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

7 January 2021

Delayed immune aging in diet-restricted B6CBAT6 F1 mice is associated with preservation of naive T cells

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

7 January 2021

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease

1 reference

https://api.crossref.org/works/10.1038%2FS41590-017-0006-X

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10.1038/S41590-017-0006-X

Identifiers

DOI

1 reference

13 January 2018

PubMed ID

29242543

1 reference

13 January 2018