(Q47709977)

English

Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis

scientific article published on 26 September 2017

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scholarly article

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Europe PubMed Central

PubMed publication ID

5 February 2018

http://europepmc.org/abstract/MED/28972001

Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis (English)

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Europe PubMed Central

PubMed publication ID

5 February 2018

http://europepmc.org/abstract/MED/28972001

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Jan Tauber

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Cheng-Jun Hu

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Nicholas W Morrell

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Nicholas W Morrell

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Hui Zhang

1

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5 February 2018

http://europepmc.org/abstract/MED/28972001

Daren Wang

2

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5 February 2018

http://europepmc.org/abstract/MED/28972001

Min Li

3

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5 February 2018

http://europepmc.org/abstract/MED/28972001

Lydie Plecitá-Hlavatá

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5 February 2018

http://europepmc.org/abstract/MED/28972001

Angelo D'Alessandro

5

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http://europepmc.org/abstract/MED/28972001

Suzette Riddle

7

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http://europepmc.org/abstract/MED/28972001

Sushil Kumar

8

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http://europepmc.org/abstract/MED/28972001

Amanda Flockton

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http://europepmc.org/abstract/MED/28972001

B Alexandre McKeon

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http://europepmc.org/abstract/MED/28972001

Maria G Frid

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http://europepmc.org/abstract/MED/28972001

Julie A Reisz

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http://europepmc.org/abstract/MED/28972001

Paola Caruso

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Karim C El Kasmi

14

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5 February 2018

http://europepmc.org/abstract/MED/28972001

Petr Ježek

15

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5 February 2018

http://europepmc.org/abstract/MED/28972001

Kurt R Stenmark

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26 September 2017

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http://europepmc.org/abstract/MED/28972001

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http://europepmc.org/abstract/MED/28972001

2468-2485

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Europe PubMed Central

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5 February 2018

http://europepmc.org/abstract/MED/28972001

Hallmarks of Pulmonary Hypertension: Mesenchymal and Inflammatory Cell Metabolic Reprogramming

1 reference

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Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction.

1 reference

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1 reference

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Translational Advances in the Field of Pulmonary Hypertension. From Cancer Biology to New Pulmonary Arterial Hypertension Therapeutics. Targeting Cell Growth and Proliferation Signaling Hubs.

1 reference

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26 August 2018

Metabolic Reprogramming Regulates the Proliferative and Inflammatory Phenotype of Adventitial Fibroblasts in Pulmonary Hypertension Through the Transcriptional Corepressor C-Terminal Binding Protein-1.

1 reference

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26 August 2018

Inhibition of histone deacetylase reduces transcription of NADPH oxidases and ROS production and ameliorates pulmonary arterial hypertension

1 reference

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26 August 2018

Molecular Mechanisms of Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension

1 reference

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26 August 2018

Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed Rat Lung

1 reference

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26 August 2018

Pyruvate and Metabolic Flexibility: Illuminating a Path Toward Selective Cancer Therapies

1 reference

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26 August 2018

Constitutive Reprogramming of Fibroblast Mitochondrial Metabolism in Pulmonary Hypertension.

1 reference

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26 August 2018

Pyruvate kinase: Function, regulation and role in cancer

1 reference

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26 August 2018

Adventitia and perivascular cells

1 reference

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26 August 2018

Metabolic reprogramming and inflammation act in concert to control vascular remodeling in hypoxic pulmonary hypertension

1 reference

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26 August 2018

MicroRNA-124 inhibits cancer cell growth through PTB1/PKM1/PKM2 feedback cascade in colorectal cancer

1 reference

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Advances in therapeutic interventions for patients with pulmonary arterial hypertension

1 reference

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26 August 2018

Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages

1 reference

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Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation

1 reference

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A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth

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Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans

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Mitochondria: roles in pulmonary hypertension.

1 reference

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1 reference

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Adventitial fibroblasts induce a distinct proinflammatory/profibrotic macrophage phenotype in pulmonary hypertension

1 reference

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New Insights into the Connection Between Histone Deacetylases, Cell Metabolism, and Cancer.

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New and emerging HDAC inhibitors for cancer treatment

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Updated treatment algorithm of pulmonary arterial hypertension.

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MicroRNA-124 controls the proliferative, migratory, and inflammatory phenotype of pulmonary vascular fibroblasts

1 reference

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Heterogeneity in lung (18)FDG uptake in pulmonary arterial hypertension: potential of dynamic (18)FDG positron emission tomography with kinetic analysis as a bridging biomarker for pulmonary vascular remodeling targeted treatments.

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MicroRNA-124 suppresses the transactivation of nuclear factor of activated T cells by targeting multiple genes and inhibits the proliferation of pulmonary artery smooth muscle cells

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The role of the adventitia in vascular inflammation

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26 August 2018

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10.1161/CIRCULATIONAHA.117.028069

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Europe PubMed Central

PubMed publication ID

5 February 2018

http://europepmc.org/abstract/MED/28972001

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5 February 2018

http://europepmc.org/abstract/MED/28972001

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