(Q27024293)

inferred from title

pulmonary hypertension

1 reference

inferred from title

author name string

Katherine A. Cottrill

series ordinal

1

1 reference

Stephen Y. Chan

series ordinal

2

1 reference

language of work or name

1 reference

August 2013

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European Journal of Clinical Investigation

published in

1 reference

volume

43

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issue

8

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page(s)

855-65

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The emerging paradigm of network medicine in the study of human disease

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MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2

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A new role for Nogo as a regulator of vascular remodeling

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21 March 2017

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HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

21 March 2017

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Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial

21 March 2017

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The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase

21 March 2017

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Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha

21 March 2017

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The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted

21 March 2017

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An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension

21 March 2017

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Otto Warburg's contributions to current concepts of cancer metabolism

21 March 2017

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Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

7 April 2017

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Metabolomic analysis of bone morphogenetic protein receptor type 2 mutations in human pulmonary endothelium reveals widespread metabolic reprogramming

7 April 2017

1 reference

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Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation

28 September 2017

1 reference

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Lung ¹⁸F-fluorodeoxyglucose positron emission tomography for diagnosis and monitoring of pulmonary arterial hypertension

28 September 2017

1 reference

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A fatal mitochondrial disease is associated with defective NFU1 function in the maturation of a subset of mitochondrial Fe-S proteins

28 September 2017

1 reference

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High levels of zinc-protoporphyrin identify iron metabolic abnormalities in pulmonary arterial hypertension

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736346

Endothelin-1, the unfolded protein response, and persistent inflammation: role of pulmonary artery smooth muscle cells

28 September 2017

1 reference

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Revisiting the TCA cycle: signaling to tumor formation

28 September 2017

1 reference

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Current pathophysiological concepts and management of pulmonary hypertension.

28 September 2017

1 reference

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Role for miR-204 in human pulmonary arterial hypertension

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736346

Mitochondrial metabolic adaptation in right ventricular hypertrophy and failure

28 September 2017

1 reference

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Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies

28 September 2017

1 reference

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Chronic pulmonary artery pressure elevation is insufficient to explain right heart failure.

28 September 2017

1 reference

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Updated clinical classification of pulmonary hypertension.

28 September 2017

1 reference

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Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species.

28 September 2017

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ACCF/AHA 2009 expert consensus document on pulmonary hypertension: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association: developed in collaboration with the American Co

28 September 2017

1 reference

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Iron-sulfur cluster biogenesis and human disease

28 September 2017

1 reference

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Coordination of growth and endoplasmic reticulum stress signaling by regulator of calcineurin 1 (RCAN1), a novel ATF6-inducible gene

28 September 2017

1 reference

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Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1.

28 September 2017

1 reference

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A meta-analysis of trials of pulmonary hypertension: a clinical condition looking for drugs and research methodology

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736346

Alterations of cellular bioenergetics in pulmonary artery endothelial cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736346

Mitochondrial Ca2+ uptake with and without the formation of high-Ca2+ microdomains

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736346

A randomized clinical trial of trimetazidine, a partial free fatty acid oxidation inhibitor, in patients with heart failure

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736346

Multifaceted roles of glycolytic enzymes.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736346

Hypoxic pulmonary vasoconstriction: redox regulation of O2-sensitive K+ channels by a mitochondrial O2-sensor in resistance artery smooth muscle cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736346

Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736346

Flirting in little space: the ER/mitochondria Ca2+ liaison

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736346

Pulmonary hypertension in chronic obstructive pulmonary disease.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736346

Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736346

The mitochondrion in apoptosis: how Pandora's box opens

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736346

Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736346

Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736346

Holding our breath: The emerging and anticipated roles of microRNA in pulmonary hypertension

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736346

Targeting energetic metabolism: a new frontier in the pathogenesis and treatment of pulmonary hypertension

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736346

The role of Nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736346

Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions. Potential for pharmacological interventions

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736346

Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease?

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736346

In vivo gene transfer of the O2-sensitive potassium channel Kv1.5 reduces pulmonary hypertension and restores hypoxic pulmonary vasoconstriction in chronically hypoxic rats

31 May 2018

1 reference

Diversity in mitochondrial function explains differences in vascular oxygen sensing.

21 January 2018

1 reference

Function of Kv1.5 channels and genetic variations of KCNA5 in patients with idiopathic pulmonary arterial hypertension

21 January 2018

1 reference

Pyruvate dehydrogenase inhibition by the inflammatory cytokine TNFα contributes to the pathogenesis of pulmonary arterial hypertension.

21 January 2018

1 reference

Increased [18F]fluorodeoxyglucose accumulation in right ventricular free wall in patients with pulmonary hypertension and the effect of epoprostenol

21 January 2018

1 reference

The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle

21 January 2018

1 reference

Microarray analysis reveals pivotal divergent mRNA expression profiles early in the development of either compensated ventricular hypertrophy or heart failure

21 January 2018

1 reference

Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning?

21 January 2018

1 reference

Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, and cyclosporin A-sensitive channel.

21 January 2018

1 reference

Observations on the Pulmonary Arterial Blood Pressure in the Cat

21 January 2018

1 reference

Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertension

21 January 2018

1 reference

The effect of trimetazidine added to maximal anti-ischemic therapy in patients with advanced coronary artery disease

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736346

Augmented K(+) currents and mitochondrial membrane depolarization in pulmonary artery myocyte apoptosis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736346

Outward currents in normal and hypertrophied feline ventricular myocytes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736346

Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension

28 November 2018

1 reference

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

21 January 2018

1 reference

12 December 2020

A comparison between ranolazine and CVT-4325, a novel inhibitor of fatty acid oxidation, on cardiac metabolism and left ventricular function in rat isolated perfused heart during ischemia and reperfusion

1 reference

12 December 2020

The microRNA-328 regulates hypoxic pulmonary hypertension by targeting at insulin growth factor 1 receptor and L-type calcium channel-α1C

1 reference

12 December 2020

Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts

1 reference

12 December 2020

Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity

1 reference

12 December 2020

Apical right ventricular dysfunction in patients with pulmonary hypertension demonstrated with magnetic resonance

1 reference

12 December 2020

Studies on the Pasteur effect. II. Specific mechanisms

1 reference

12 December 2020

Linking new and old concepts: inflammation meets the Warburg phenomenon in pulmonary arterial hypertension

1 reference

12 December 2020

Dichloroacetate as metabolic therapy for myocardial ischemia and failure

1 reference

12 December 2020

Metabolic effects and pharmacokinetics of intravenously administered dichloroacetate in humans

1 reference

12 December 2020

Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species

1 reference

12 December 2020

Effects of dichloroacetate in patients with congestive heart failure

1 reference

12 December 2020

Identifiers

DOI

10.1111/ECI.12104

1 reference

1 reference

1 reference

PubMed publication ID

23617881

1 reference