(Q37544085)

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Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages

scientific article published on January 2015

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scholarly article

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Europe PubMed Central

20 August 2017

Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages (English)

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20 August 2017

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13 June 2020

Frederick J. Sheedy

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13 June 2020

Frederick J. Sheedy

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13 June 2020

Daniel G W Johnston

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13 June 2020

William J Israelsen

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13 June 2020

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13 June 2020

Craig J. Thomas

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13 June 2020

Luke A. J. O'Neill

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13 June 2020

Ramnik J Xavier

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Ramnik J Xavier

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13 June 2020

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Eva M Palsson-McDermott

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13 June 2020

Gautam Goel

3

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13 June 2020

Mario A R Lauterbach

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13 June 2020

Laura E Gleeson

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13 June 2020

Mirjam W M van den Bosch

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13 June 2020

Susan R Quinn

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13 June 2020

Raquel Domingo-Fernandez

10

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13 June 2020

Jian-Kang Jiang

12

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13 June 2020

Clary Clish

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13 June 2020

Matthew Vander Heiden

17

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13 June 2020

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1 January 2015

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20 August 2017

Cell Metabolism

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13 June 2020

21

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13 June 2020

1

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13 June 2020

65-80

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13 June 2020

PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis

1 reference

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23 August 2017

The role of Ets2 transcription factor in the induction of microRNA-155 (miR-155) by lipopolysaccharide and its targeting by interleukin-10

1 reference

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23 August 2017

JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α-mediated glucose metabolism.

1 reference

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23 August 2017

PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.

1 reference

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23 August 2017

Nuclear PKM2 regulates the Warburg effect.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198835

23 August 2017

Succinate is an inflammatory signal that induces IL-1β through HIF-1α.

1 reference

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23 August 2017

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

1 reference

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23 August 2017

SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions

1 reference

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23 August 2017

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

1 reference

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23 August 2017

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

1 reference

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23 August 2017

Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase

1 reference

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23 August 2017

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

1 reference

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23 August 2017

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198835

23 August 2017

Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

1 reference

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23 August 2017

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

1 reference

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23 August 2017

Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

1 reference

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23 August 2017

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

1 reference

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23 August 2017

Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF.

1 reference

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23 August 2017

TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis.

1 reference

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23 August 2017

Pyruvate kinase type M2 and its role in tumor growth and spreading

1 reference

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23 August 2017

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

1 reference

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23 August 2017

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

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23 August 2017

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

1 reference

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23 August 2017

Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis

1 reference

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23 August 2017

The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate

1 reference

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23 August 2017

Isolation and characterization of the human pyruvate kinase M gene

1 reference

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23 August 2017

In vivo regulation of monomer-tetramer conversion of pyruvate kinase subtype M2 by glucose is mediated via fructose 1,6-bisphosphate

1 reference

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23 August 2017

Metabolism of inflammation limited by AMPK and pseudo-starvation

1 reference

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6 September 2017

Dual roles of PKM2 in cancer metabolism

1 reference

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6 September 2017

Pyruvate kinase M2: multiple faces for conferring benefits on cancer cells.

1 reference

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6 September 2017

IL-10 blocks phagosome maturation in mycobacterium tuberculosis-infected human macrophages

1 reference

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14 September 2017

Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth

1 reference

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14 September 2017

Concentration-dependent control of pyruvate kinase M mutually exclusive splicing by hnRNP proteins

1 reference

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28 September 2017

Cutting edge: Essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis

1 reference

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1 September 2018

Evidence that hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of interleukin-1beta (IL-1beta) in astrocyte cultures

1 reference

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1 September 2018

Identifiers

10.1016/J.CMET.2014.12.005

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13 June 2020

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Europe PubMed Central

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13 June 2020

1 reference

Europe PubMed Central

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13 June 2020

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