(Q47848908)

English

Pharmacological targeting of the ephrin receptor kinase signalling by GLPG1790 in vitro and in vivo reverts oncophenotype, induces myogenic differentiation and radiosensitizes embryonal rhabdomyosarcoma cells.

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Europe PubMed Central

PubMed publication ID

6 February 2018

http://europepmc.org/abstract/MED/28985758

Pharmacological targeting of the ephrin receptor kinase signalling by GLPG1790 in vitro and in vivo reverts oncophenotype, induces myogenic differentiation and radiosensitizes embryonal rhabdomyosarcoma cells (English)

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6389084&resulttype=core&format=json

13 May 2020

embryonal rhabdomyosarcoma

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Francesco Marampon

21

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6389084&resulttype=core&format=json

13 May 2020

3

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6389084&resulttype=core&format=json

13 May 2020

Andrea Del Fattore

5

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PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6389084&resulttype=core&format=json

13 May 2020

Vincenzo Desiderio

6

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6389084&resulttype=core&format=json

13 May 2020

Federica Papaccio

7

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6389084&resulttype=core&format=json

13 May 2020

Antonio Pizzuti

10

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6389084&resulttype=core&format=json

13 May 2020

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Francesca Megiorni

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6389084&resulttype=core&format=json

13 May 2020

Giovanni Luca Gravina

2

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6389084&resulttype=core&format=json

13 May 2020

Simona Ceccarelli

4

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PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6389084&resulttype=core&format=json

13 May 2020

Heather P McDowell

8

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6389084&resulttype=core&format=json

13 May 2020

Rajeev Shukla

9

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13 May 2020

Filip Beirinckx

11

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6389084&resulttype=core&format=json

13 May 2020

Philippe Pujuguet

12

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6389084&resulttype=core&format=json

13 May 2020

Laurent Saniere

13

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6389084&resulttype=core&format=json

13 May 2020

Ellen Van der Aar

14

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6389084&resulttype=core&format=json

13 May 2020

Roberto Maggio

15

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6389084&resulttype=core&format=json

13 May 2020

Francesca De Felice

16

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6389084&resulttype=core&format=json

13 May 2020

Cinzia Marchese

17

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6389084&resulttype=core&format=json

13 May 2020

Carlo Dominici

18

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6389084&resulttype=core&format=json

13 May 2020

Vincenzo Tombolini

19

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6389084&resulttype=core&format=json

13 May 2020

Claudio Festuccia

20

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6389084&resulttype=core&format=json

13 May 2020

publication date

6 October 2017

1 reference

Europe PubMed Central

PubMed publication ID

6 February 2018

http://europepmc.org/abstract/MED/28985758

Journal of Hematology & Oncology

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6389084&resulttype=core&format=json

13 May 2020

10

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6389084&resulttype=core&format=json

13 May 2020

1

1 reference

Europe PubMed Central

PMC publication ID

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13 May 2020

161

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6389084&resulttype=core&format=json

13 May 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6389084/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Gene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Classification of rhabdomyosarcoma and its molecular basis.

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Rhabdomyosarcoma: current challenges and their implications for developing therapies.

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Eph receptor signalling casts a wide net on cell behaviour

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Eph-ephrin bidirectional signaling in physiology and disease

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Eph receptor signaling and ephrins

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Multiple roles of ephrins in morphogenesis, neuronal networking, and brain function.

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

EphrinA/EphA signal facilitates insulin-like growth factor-I-induced myogenic differentiation through suppression of the Ras/extracellular signal-regulated kinase 1/2 cascade in myoblast cell lines

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Mechanisms of ephrin-Eph signalling in development, physiology and disease.

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Eph receptors and ephrins in cancer: bidirectional signalling and beyond

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Eph receptor tyrosine kinases in tumor and tumor microenvironment

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Regulation and misregulation of Eph/ephrin expression

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Regulation of tumor initiation and metastatic progression by Eph receptor tyrosine kinases.

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Eph receptor tyrosine kinases in cancer stem cells

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Therapeutic targeting of EPH receptors and their ligands

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Eph receptors and ephrins: therapeutic opportunities

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population.

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

MEK/ERK inhibitor U0126 affects in vitro and in vivo growth of embryonal rhabdomyosarcoma.

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Integrated genetic and epigenetic analysis defines novel molecular subgroups in rhabdomyosarcoma

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

It takes two to tango: Dual inhibition of PI3K and MAPK in rhabdomyosarcoma

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Deep Sequencing the microRNA profile in rhabdomyosarcoma reveals down-regulation of miR-378 family members

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Close correlation between MEK/ERK and Aurora-B signaling pathways in sustaining tumorigenic potential and radioresistance of gynecological cancer cell lines.

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

MEK/ERK inhibitor U0126 increases the radiosensitivity of rhabdomyosarcoma cells in vitro and in vivo by downregulating growth and DNA repair signals

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Ephrin type‑A receptor 2 regulates sensitivity to paclitaxel in nasopharyngeal carcinoma via the phosphoinositide 3‑kinase/Akt signalling pathway

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Increased expression of EphA7 correlates with adverse outcome in primary and recurrent glioblastoma multiforme patients

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Knockdown of EphB1 receptor decreases medulloblastoma cell growth and migration and increases cellular radiosensitization

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

EphA2 Is a Therapy Target in EphA2-Positive Leukemias but Is Not Essential for Normal Hematopoiesis or Leukemia

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Eph/ephrin interactions modulate muscle satellite cell motility and patterning.

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Gene Expression Profiling of Muscle Stem Cells Identifies Novel Regulators of Postnatal Myogenesis

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Impact of differential cyclin D1 expression and localisation in prostate cancer

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Proliferation precedes differentiation in IGF-I-stimulated myogenesis

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Phosphoprotein pathway mapping: Akt/mammalian target of rapamycin activation is negatively associated with childhood rhabdomyosarcoma survival

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Down-regulation of c-Myc following MEK/ERK inhibition halts the expression of malignant phenotype in rhabdomyosarcoma and in non muscle-derived human tumors.

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Loss-of-function screen in rhabdomyosarcoma identifies CRKL-YES as a critical signal for tumor growth

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Inhibition of Notch3 signalling induces rhabdomyosarcoma cell differentiation promoting p38 phosphorylation and p21(Cip1) expression and hampers tumour cell growth in vitro and in vivo.

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

PPARγ agonists enhance ET-743-induced adipogenic differentiation in a transgenic mouse model of myxoid round cell liposarcoma

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Radiation-induced signaling pathways that promote cancer cell survival (review).

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Ephrin-B2 overexpression predicts for poor prognosis and response to therapy in solid tumors

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Molecular Pathways: Overcoming Radiation Resistance by Targeting DNA Damage Response Pathways

1 reference

https://api.crossref.org/works/10.1186%2FS13045-017-0530-Z

21 January 2018

Rhabdomyosarcoma: an overview

1 reference

https://pubmed.ncbi.nlm.nih.gov/28985758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced antitumor activity of anti-epidermal growth factor receptor monoclonal antibody IMC-C225 in combination with irinotecan (CPT-11) against human colorectal tumor xenografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/28985758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear receptor agonists as potential differentiation therapy agents for human osteosarcoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/28985758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Up-regulation of EphB and ephrin-B expression in rhabdomyosarcoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28985758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gamma-H2AX - a novel biomarker for DNA double-strand breaks.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28985758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA damage-induced ephrin-B2 reverse signaling promotes chemoresistance and drives EMT in colorectal carcinoma harboring mutant p53

1 reference

https://pubmed.ncbi.nlm.nih.gov/28985758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Current status of treatment for pediatric rhabdomyosarcoma in the USA and Japan

1 reference

https://pubmed.ncbi.nlm.nih.gov/28985758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNMT3B in vitro knocking-down is able to reverse embryonal rhabdomyosarcoma cell phenotype through inhibition of proliferation and induction of myogenic differentiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28985758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of cyclin D1 and retinoblastoma protein in colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28985758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/S13045-017-0530-Z

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6389084&resulttype=core&format=json

13 May 2020

Dimensions Publication ID

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/s13045-017-0530-z

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6389084&resulttype=core&format=json

13 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6389084&resulttype=core&format=json

13 May 2020

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