(Q47995331)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28771691%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

title

Targeting HECT-type E3 ligases - insights from catalysis, regulation and inhibitors (English)

1 reference

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26 March 2020

2

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26 March 2020

author name string

Valentina Fajner

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28771691%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Simona Polo

series ordinal

3

1 reference

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26 March 2020

language of work or name

English

0 references

publication date

20 August 2017

1 reference

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26 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28771691%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

volume

591

1 reference

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26 March 2020

issue

17

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26 March 2020

page(s)

2636-2647

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28771691%20AND%20SRC:MED&resulttype=core&format=json

Ubiquitin in trafficking: the network at work

26 March 2020

cites work

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Ubiquitin and membrane protein turnover: from cradle to grave

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Nonproteolytic functions of ubiquitin in cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Mammalian HECT ubiquitin-protein ligases: biological and pathophysiological aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Cargo recognition and trafficking in selective autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

New insights into ubiquitin E3 ligase mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Structural insights into the catalysis and regulation of E3 ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

RBR E3 ubiquitin ligases: new structures, new insights, new questions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Physiological functions of the HECT family of ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Signaling through C2 domains: more than one lipid target

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Structure of a WW domain containing fragment of dystrophin in complex with beta-dystroglycan

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Structural basis for phosphoserine-proline recognition by group IV WW domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

NeW wrinkles for an old domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

WW domains provide a platform for the assembly of multiprotein networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Insights into Ubiquitin Transfer Cascades from a Structure of a UbcH5B∼Ubiquitin-HECTNEDD4L Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Structure of a conjugating enzyme-ubiquitin thiolester intermediate reveals a novel role for the ubiquitin tail

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Structure of an E3:E2~Ub complex reveals an allosteric mechanism shared among RING/U-box ligases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Essential role for ubiquitin-ubiquitin-conjugating enzyme interaction in ubiquitin discharge from Cdc34 to substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Molecular insights into RBR E3 ligase ubiquitin transfer mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

The -4 phenylalanine is required for substrate ubiquitination catalyzed by HECT ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Regulation of the RSP5 ubiquitin ligase by an intrinsic ubiquitin-binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

The ubiquitin binding region of the Smurf HECT domain facilitates polyubiquitylation and binding of ubiquitylated substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Polyubiquitination by HECT E3s and the determinants of chain type specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Atypical ubiquitylation - the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Ubiquitin: same molecule, different degradation pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

A Human Ubiquitin Conjugating Enzyme (E2)-HECT E3 Ligase Structure-function Screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Mechanism of ubiquitin chain synthesis employed by a HECT domain ubiquitin ligase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

The HECT family of E3 ubiquitin ligases: multiple players in cancer development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Ubiquitin ligase Nedd4 promotes alpha-synuclein degradation by the endosomal-lysosomal pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Fine-tuning of ULK1 mRNA and protein levels is required for autophagy oscillation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Deubiquitinase activity is required for the proteasomal degradation of misfolded cytosolic proteins upon heat-stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

SUMO-targeted ubiquitin ligases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Different HECT domain ubiquitin ligases employ distinct mechanisms of polyubiquitin chain synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

E6AP/UBE3A ubiquitin ligase harbors two E2~ubiquitin binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Role of ubiquitin and the HPV E6 oncoprotein in E6AP-mediated ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

A conformational switch regulates the ubiquitin ligase HUWE1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Structural and functional framework for the autoinhibition of Nedd4-family ubiquitin ligases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Regulation of Nedd4-2 self-ubiquitination and stability by a PY motif located within its HECT-domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Itch WW Domains Inhibit Its E3 Ubiquitin Ligase Activity by Blocking E2-E3 Ligase Trans-thiolation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

A Tunable Brake for HECT Ubiquitin Ligases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Allosteric auto-inhibition and activation of the Nedd4 family E3 ligase Itch.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Ubiquitylation-dependent oligomerization regulates activity of Nedd4 ligases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Signaling-mediated control of ubiquitin ligases in endocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Calcium activates Nedd4 E3 ubiquitin ligases by releasing the C2 domain-mediated auto-inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Structural basis of the activation and degradation mechanisms of the E3 ubiquitin ligase Nedd4L

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Physical and functional interaction of the HECT ubiquitin-protein ligases E6AP and HERC2

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Targeting ubiquitin specific proteases for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Sorafenib for the treatment of advanced renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Identification of a primary target of thalidomide teratogenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Peptide and small molecule inhibitors of HECT-type ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

The antiproliferative response of indole-3-carbinol in human melanoma cells is triggered by an interaction with NEDD4-1 and disruption of wild-type PTEN degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Indole-3-carbinol (I3C) analogues are potent small molecule inhibitors of NEDD4-1 ubiquitin ligase activity that disrupt proliferation of human melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

Drugging the undruggables: exploring the ubiquitin system for drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12775

21 January 2018

Identifiers

DOI

10.1002/1873-3468.12775

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28771691%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

1 reference