(Q48125960)

English

TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson's disease brains.

scientific article published on 14 July 2010

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scholarly article

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20634198%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson's disease brains (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20634198%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

protein ubiquitination

1 reference

based on heuristic

inferred from title

Parkinson's disease

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Silvia Zucchelli

1

1 reference

Europe PubMed Central

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7 February 2020

4

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7 February 2020

6

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7 February 2020

Stefano Gustincich

8

object named as

Stefano Gustincich

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Europe PubMed Central

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7 February 2020

author name string

Marta Codrich

2

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7 February 2020

Federica Marcuzzi

3

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7 February 2020

Sandra Vilotti

5

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7 February 2020

Isidro Ferrer

7

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7 February 2020

publication date

14 July 2010

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7 February 2020

Human Molecular Genetics

1 reference

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7 February 2020

19

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7 February 2020

19

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7 February 2020

3759-3770

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7 February 2020

Parkinson's disease: from monogenic forms to genetic susceptibility factors

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Dorfin Localizes to Lewy Bodies and Ubiquitylates Synphilin-1

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Nonproteolytic functions of ubiquitin in cell signaling

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Lysosomal localization of ubiquitinated Jun requires multiple determinants in a lysine-27-linked polyubiquitin conjugate

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Aggresome-forming TTRAP mediates pro-apoptotic properties of Parkinson's disease-associated DJ-1 missense mutations.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Ubiquitin signalling in the NF-kappaB pathway

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Association of the p75 neurotrophin receptor with TRAF6

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation and apoptotic cell death.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Parkin and synphilin-1 isoform expression changes in Lewy body diseases.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

In vivo evidence of CHIP up-regulation attenuating tau aggregation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Human brain cortex: mitochondrial oxidative damage and adaptive response in Parkinson disease and in dementia with Lewy bodies.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

The Lewy body in Parkinson's disease: molecules implicated in the formation and degradation of alpha-synuclein aggregates

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Molecular pathology of Lewy body diseases.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Alpha-synuclein in Lewy bodies

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Unexpected expression of alpha- and beta-globin in mesencephalic dopaminergic neurons and glial cells

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

The DJ-1L166P mutant protein associated with early onset Parkinson's disease is unstable and forms higher-order protein complexes

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

On the oligomeric state of DJ-1 protein and its mutants associated with Parkinson Disease. A combined computational and in vitro study.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Parkin-mediated ubiquitin signalling in aggresome formation and autophagy

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Parkin-mediated K63-linked polyubiquitination: a signal for targeting misfolded proteins to the aggresome-autophagy pathway.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Siah-1 facilitates ubiquitination and degradation of synphilin-1

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Ubiquitination of alpha-synuclein and autophagy in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Monoubiquitylation of alpha-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

Immunohistochemical staining of post-mortem adult human brain sections.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

TNFR-associated factor-2 (TRAF-2) in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ290

21 January 2018

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