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Parkin-mediated ubiquitin signalling in aggresome formation and autophagy
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
20074049
retrieved
29 July 2017
review article
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stated in
Europe PubMed Central
title
Parkin-mediated ubiquitin signalling in aggresome formation and autophagy
(English)
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stated in
Europe PubMed Central
PubMed ID
20074049
retrieved
29 July 2017
main subject
autophagy
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author
Lih-Shen Chin
object named as
Lih-Shen Chin
series ordinal
1
0 references
Lian Li
object named as
Lian Li
series ordinal
3
0 references
James Olzmann
object named as
James A Olzmann
series ordinal
2
0 references
publication date
1 February 2010
1 reference
stated in
Europe PubMed Central
PubMed ID
20074049
retrieved
29 July 2017
published in
Biochemical Society Transactions
1 reference
stated in
Europe PubMed Central
PubMed ID
20074049
retrieved
29 July 2017
volume
38
1 reference
stated in
Europe PubMed Central
PubMed ID
20074049
retrieved
29 July 2017
issue
Pt 1
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stated in
Europe PubMed Central
PubMed ID
20074049
retrieved
29 July 2017
page(s)
144-149
1 reference
stated in
Europe PubMed Central
PubMed ID
20074049
retrieved
29 July 2017
cites work
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
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21 June 2018
The ubiquitin-proteasome system in spongiform degenerative disorders
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21 June 2018
Aggresome formation and neurodegenerative diseases: therapeutic implications
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PubMed Central
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21 June 2018
Autophagy in the Pathogenesis of Disease
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21 June 2018
Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins
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21 June 2018
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice
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21 June 2018
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease
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21 June 2018
Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases
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PubMed Central
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21 June 2018
Parkin-mediated K63-linked polyubiquitination: a signal for targeting misfolded proteins to the aggresome-autophagy pathway.
1 reference
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PubMed Central
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21 June 2018
Autophagosome formation: core machinery and adaptations
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21 June 2018
Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846638
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21 June 2018
ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration
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PubMed Central
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21 June 2018
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
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PubMed Central
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21 June 2018
HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS
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21 June 2018
Pathogenic mutations in Parkinson disease
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PubMed Central
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21 June 2018
Autophagy and neurodegeneration: when the cleaning crew goes on strike
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PubMed Central
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21 June 2018
Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling
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PubMed Central
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21 June 2018
A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling
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PubMed Central
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21 June 2018
Autophagy in neurodegenerative disease: friend, foe or turncoat?
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21 June 2018
ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B)
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846638
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21 June 2018
Protein misfolding disorders: pathogenesis and intervention
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846638
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21 June 2018
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846638
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21 June 2018
Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846638
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21 June 2018
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846638
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21 June 2018
HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin
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PubMed Central
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21 June 2018
Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation
1 reference
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PubMed Central
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21 June 2018
Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846638
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21 June 2018
Dynein mutations impair autophagic clearance of aggregate-prone proteins
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846638
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21 June 2018
Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846638
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21 June 2018
Pathogenetic mechanisms of parkin in Parkinson's disease
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846638
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21 June 2018
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846638
retrieved
21 June 2018
The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846638
retrieved
21 June 2018
Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846638
retrieved
21 June 2018
Crystal structure of DJ-1/RS and implication on familial Parkinson's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846638
retrieved
21 June 2018
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846638
retrieved
21 June 2018
Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846638
retrieved
21 June 2018
Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846638
retrieved
21 June 2018
Aggresomes, inclusion bodies and protein aggregation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846638
retrieved
21 June 2018
Ubiquitin tag for sperm mitochondria
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846638
retrieved
21 June 2018
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846638
retrieved
21 June 2018
Proteolysis of mitochondria in reticulocytes during maturation is ubiquitin-dependent and is accompanied by a high rate of ATP hydrolysis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846638
retrieved
21 June 2018
Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846638
retrieved
30 October 2018
Global changes to the ubiquitin system in Huntington's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846638
retrieved
30 October 2018
Parkin: a multifaceted ubiquitin ligase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846638
retrieved
30 October 2018
Rapamycin alleviates toxicity of different aggregate-prone proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846638
retrieved
30 October 2018
Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846638
retrieved
30 October 2018
Mutations in dynein link motor neuron degeneration to defects in retrograde transport
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846638
retrieved
30 October 2018
Mutant dynactin in motor neuron disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846638
retrieved
30 October 2018
Cytoplasmic dynein/dynactin mediates the assembly of aggresomes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846638
retrieved
30 October 2018
Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846638
retrieved
30 October 2018
Identifiers
DOI
10.1042/BST0380144
1 reference
stated in
Europe PubMed Central
PubMed ID
20074049
retrieved
29 July 2017
PMCID
2846638
1 reference
stated in
Europe PubMed Central
PubMed ID
20074049
retrieved
29 July 2017
PubMed ID
20074049
1 reference
stated in
Europe PubMed Central
PubMed ID
20074049
retrieved
29 July 2017
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