(Q48251327)

10 February 2018

title

Revealing the macromolecular targets of complex natural products (English)

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10 February 2018

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3

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Rolf Müller

11

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Christina Lamers

Christina Lamers

8

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Daniel Reker

Daniel Reker

1

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Gisbert Schneider

14

Gisbert Schneider

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10 February 2018

7

Andreas Koeberle

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Manfred Schubert-Zsilavecz

10 February 2018

12

Manfred Schubert-Zsilavecz

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10 February 2018

13

Oliver Werz

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4

Petra Schneider

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10 February 2018

author name string

Anna M Perna

2

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Michael Reutlinger

5

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Bettina Mönch

6

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Matthias Gabler

9

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10 February 2018

Heinrich Steinmetz

10

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10 February 2018

publication date

2 November 2014

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10 February 2018

published in

Nature Chemistry

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10 February 2018

volume

6

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10 February 2018

issue

12

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10 February 2018

page(s)

1072-1078

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10 February 2018

The evolving role of natural products in drug discovery

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Novel chemical space exploration via natural products

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A ring-distortion strategy to construct stereochemically complex and structurally diverse compounds from natural products.

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Charting, navigating, and populating natural product chemical space for drug discovery

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Drug discovery: Predicting promiscuity

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Multi-targeted natural products evaluation based on biological activity prediction with PASS.

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Natural-product-derived fragments for fragment-based ligand discovery

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Chemically Advanced Template Search (CATS) for Scaffold-Hopping and Prospective Target Prediction for 'Orphan' Molecules

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Self-organizing maps in drug discovery: compound library design, scaffold-hopping, repurposing

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Scaffold diversity of natural products: inspiration for combinatorial library design

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Scaffold architecture and pharmacophoric properties of natural products and trade drugs: application in the design of natural product-based combinatorial libraries

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Identifying the macromolecular targets of de novo-designed chemical entities through self-organizing map consensus

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Evolution of the physicochemical properties of marketed drugs: can history foretell the future?

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Expanding the medicinally relevant chemical space with compound libraries

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RECAP--retrosynthetic combinatorial analysis procedure: a powerful new technique for identifying privileged molecular fragments with useful applications in combinatorial chemistry

21 January 2018

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Inhibitors of V-ATPases: old and new players

21 January 2018

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Mode of cell death induction by pharmacological vacuolar H+-ATPase (V-ATPase) inhibition

21 January 2018

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The V-ATPase-inhibitor archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1.

21 January 2018

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Archazolid and apicularen: novel specific V-ATPase inhibitors

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Understanding the inhibitory effect of highly potent and selective archazolides binding to the vacuolar ATPase

21 January 2018

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Specificity of arachidonic acid-induced inhibition of growth and activation of c-jun kinases and p38 mitogen-activated protein kinase in hematopoietic cells

21 January 2018

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Unsaturated fatty acid modulation of glucocorticoid receptor binding in L2 cells

21 January 2018

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Investigating Substrate Promiscuity in Cyclooxygenase-2: THE ROLE OF ARG-120 AND RESIDUES LINING THE HYDROPHOBIC GROOVE

21 January 2018

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Identification of a chemical tool for the orphan nuclear receptor FXR.

21 January 2018

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Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity

21 January 2018

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6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.

21 January 2018

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Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma

21 January 2018

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15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma

21 January 2018

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5-Lipoxygenase inhibitors induce potent anti-proliferative and cytotoxic effects in human tumour cells independently of suppression of 5-lipoxygenase activity

21 January 2018

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Critical role of farnesoid X receptor for hepatocellular carcinoma cell proliferation

21 January 2018

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Synthesis and activity of the archazolid western hemisphere

21 January 2018

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Archazolid A-15-O-β-d-glucopyranoside andiso-Archazolid B: Potent V-ATPase Inhibitory Polyketides from the MyxobacteriaCystobacter violaceusandArchangium gephyra

21 January 2018

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12 December 2020

MK886 inhibits the proliferation of HL-60 leukemia cells by suppressing the expression of mPGES-1 and reducing prostaglandin E2 synthesis

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12 December 2020

Design, synthesis, and evaluation of non-steroidal farnesoid X receptor (FXR) antagonist

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12 December 2020

"Scaffold-Hopping" by Topological Pharmacophore Search: A Contribution to Virtual Screening

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12 December 2020

Inhibition of cell proliferation by potential peroxisome proliferator-activated receptor (PPAR) gamma agonists and antagonists.

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12 December 2020

Virtual screening for the discovery of bioactive natural products

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https://api.crossref.org/works/10.1038%2FNCHEM.2095

7 January 2021

inferred from DOI database lookup

Truncated militarinone fragments identified by total chemical synthesis induce neurite outgrowth

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2095

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NCHEM.2095

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10 February 2018

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10 February 2018