(Q48287894)

10 February 2018

review article

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title

Down syndrome: the brain in trisomic mode. (English)

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10 February 2018

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1

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10 February 2018

language of work or name

English

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publication date

1 December 2012

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10 February 2018

Nature Reviews Neuroscience

published in

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10 February 2018

volume

13

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10 February 2018

issue

12

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10 February 2018

page(s)

844-858

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10 February 2018

https://scigraph.springernature.com/pub.10.1038/nrn3314

exact match

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Working memory and Down syndrome

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Working memory in Down syndrome: is there a dual task deficit?

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Aneuploidy: from a physiological mechanism of variance to Down syndrome

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Behavioral phenotype of individuals with Down syndrome

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A comparison of language abilities in adolescents with Down syndrome and children with specific language impairment.

31 March 2020

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Impaired verbal short-term memory in Down syndrome reflects a capacity limitation rather than atypically rapid forgetting.

31 March 2020

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Visual and spatial working memory: from boxes to networks

31 March 2020

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Visual-spatial processing in children and adolescents with Down's syndrome: a computerized assessment of memory skills.

31 March 2020

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A specific deficit in visuospatial simultaneous working memory in Down syndrome.

31 March 2020

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General intelligence and memory span: evidence for a common neuroanatomic framework.

31 March 2020

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Individual differences in working memory

31 March 2020

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Remembering over the short-term: the case against the standard model.

31 March 2020

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The role of vocabulary, working memory and inference making ability in reading comprehension in Down syndrome.

31 March 2020

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Exploring the forgetting mechanisms in working memory: evidence from a reasoning span test.

31 March 2020

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Executive function in adolescents with Down Syndrome.

31 March 2020

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Phonological awareness of children with Down syndrome: its role in learning to read and the effectiveness of related interventions

31 March 2020

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Neuropsychological correlates of word identification in Down syndrome.

31 March 2020

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Verbal short-term memory in Down syndrome: a problem of memory, audition, or speech?

31 March 2020

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Serial order reconstruction in Down syndrome: evidence for a selective deficit in verbal short-term memory.

31 March 2020

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Bimanual coordination dynamics in adults with Down syndrome

31 March 2020

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Auditory information is beneficial for adults with Down syndrome in a continuous bimanual task

31 March 2020

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Manual and oral praxis in adults with Down's syndrome.

31 March 2020

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Cerebral specialization and the control of oral and limb movements for individuals with Down's syndrome

31 March 2020

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Gender differences in a dichotic listening and movement task: lateralization or strategy?

31 March 2020

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Cognitive control of movement in Down syndrome.

31 March 2020

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Analysis of "invariant characteristics" in the motor control of down's syndrome and normal subjects

31 March 2020

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Altered brain dynamics during voluntary movement in individuals with Down syndrome

31 March 2020

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Implicit and explicit memory: a functional dissociation in persons with Down syndrome

31 March 2020

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Solving the Raven Progressive Matrices by adults with intellectual disability with/without Down syndrome: different cognitive patterns as indicated by eye-movements.

31 March 2020

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Neuroanatomy of Down's syndrome: a high-resolution MRI study.

31 March 2020

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Selective neuroanatomic abnormalities in Down's syndrome and their cognitive correlates: evidence from MRI morphometry.

31 March 2020

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Relationship between brain and cognitive processes in Down syndrome.

31 March 2020

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Cerebral morphologic distinctions between Williams and Down syndromes

31 March 2020

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Long-term memory for verbal and visual information in Down syndrome and Williams syndrome: performance on the Doors and People test.

31 March 2020

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Evidence from two genetic syndromes for the independence of spatial and visual working memory.

31 March 2020

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Impaired plasticity at specific subset of striatal synapses in the Ts65Dn mouse model of Down syndrome.

31 March 2020

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Functional magnetic resonance imaging of cognitive processing in young adults with Down syndrome

31 March 2020

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A callosal transfer deficit in children with developmental language disorder.

31 March 2020

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The neuropsychology of Down syndrome: evidence for hippocampal dysfunction

31 March 2020

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Transcript catalogs of human chromosome 21 and orthologous chimpanzee and mouse regions

31 March 2020

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Molecular mapping of twenty-four features of Down syndrome on chromosome 21.

31 March 2020

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Down syndrome phenotypes: the consequences of chromosomal imbalance

31 March 2020

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The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies

31 March 2020

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Genotype-phenotype correlations in Down syndrome identified by array CGH in 30 cases of partial trisomy and partial monosomy chromosome 21

31 March 2020

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Down syndrome and the genes of human chromosome 21: current knowledge and future potentials

31 March 2020

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Down syndrome--recent progress and future prospects

31 March 2020

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Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations.

31 March 2020

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Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome

31 March 2020

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NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.

31 March 2020

1 reference

Meta-analysis of heterogeneous Down Syndrome data reveals consistent genome-wide dosage effects related to neurological processes

31 March 2020

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Overexpression of transcription factor BACH1 in fetal Down syndrome brain

31 March 2020

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31 March 2020

12 December 2020

Aberrant protein expression of transcription factors BACH1 and ERG, both encoded on chromosome 21, in brains of patients with Down syndrome and Alzheimer's disease

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12 December 2020

Increased dosage of the RUNX1/AML1 gene: a third mode of RUNX leukemia?

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Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome.

31 March 2020

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DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects.

31 March 2020

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Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models

31 March 2020

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A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart

31 March 2020

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Amplified developmental instability in Down's syndrome

31 March 2020

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Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes.

31 March 2020

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Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice.

31 March 2020

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Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts

31 March 2020

1 reference

Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains

31 March 2020

1 reference

Genomic profiling in Down syndrome acute lymphoblastic leukemia identifies histone gene deletions associated with altered methylation profiles

31 March 2020

1 reference

Use of comparative physical and sequence mapping to annotate mouse chromosome 16 and human chromosome 21

31 March 2020

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A mouse model for Down syndrome exhibits learning and behaviour deficits.

31 March 2020

1 reference

Alterations of neocortical pyramidal cell phenotype in the Ts65Dn mouse model of Down syndrome: effects of environmental enrichment

31 March 2020

1 reference

Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities

31 March 2020

1 reference

Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12.

31 March 2020

1 reference

Enlarged brain ventricles and impaired neurogenesis in the Ts1Cje and Ts2Cje mouse models of Down syndrome.

31 March 2020

1 reference

Trisomy for the Down syndrome 'critical region' is necessary but not sufficient for brain phenotypes of trisomic mice.

31 March 2020

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The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome

31 March 2020

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A chromosome 21 critical region does not cause specific Down syndrome phenotypes.

31 March 2020

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Differential effects of trisomy on brain shape and volume in related aneuploid mouse models

31 March 2020

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The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndrome

31 March 2020

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An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes

31 March 2020

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Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome

31 March 2020

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Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome

31 March 2020

1 reference

The triple test as a screening technique for Down syndrome: reliability and relevance

31 March 2020

1 reference

Duplication of the entire 22.9 Mb human chromosome 21 syntenic region on mouse chromosome 16 causes cardiovascular and gastrointestinal abnormalities.

31 March 2020

1 reference

Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships

31 March 2020

1 reference

A behavioral assessment of Ts65Dn mice: a putative Down syndrome model.

31 March 2020

1 reference

The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development

31 March 2020

1 reference

Spatial and temporal localization during embryonic and fetal human development of the transcription factor SIM2 in brain regions altered in Down syndrome

31 March 2020

1 reference

Mice trisomic for a bacterial artificial chromosome with the single-minded 2 gene (Sim2) show phenotypes similar to some of those present in the partial trisomy 16 mouse models of Down syndrome

31 March 2020

1 reference

The mouse brain transcriptome by SAGE: differences in gene expression between P30 brains of the partial trisomy 16 mouse model of Down syndrome (Ts65Dn) and normals

31 March 2020

1 reference

Elevated expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in cerebellar unipolar brush cells of a Down syndrome mouse model.

31 March 2020

1 reference

Trisomy of the G protein-coupled K+ channel gene, Kcnj6, affects reward mechanisms, cognitive functions, and synaptic plasticity in mice

31 March 2020

1 reference

NMDA-mediated regulation of DSCAM dendritic local translation is lost in a mouse model of Down's syndrome.

31 March 2020

1 reference

Alterations of brain circuits in Down syndrome murine models

31 March 2020

1 reference

Mouse models for Down syndrome-associated developmental cognitive disabilities

31 March 2020

1 reference

Murine models for Down syndrome

31 March 2020

1 reference

DYRK1A (dual-specificity tyrosine-phosphorylated and -regulated kinase 1A): a gene with dosage effect during development and neurogenesis.

31 March 2020

1 reference

Construction of a panel of transgenic mice containing a contiguous 2-Mb set of YAC/P1 clones from human chromosome 21q22.2.

31 March 2020

1 reference

DYRK1A: a master regulatory protein controlling brain growth.

31 March 2020

1 reference

Functional screening and complex traits: human 21q22.2 sequences affecting learning in mice

31 March 2020

1 reference

Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome.

31 March 2020

1 reference

Dendritic spines and distributed circuits

31 March 2020

1 reference

Dendritic pathology in mental retardation: from molecular genetics to neurobiology.

31 March 2020

1 reference

Understanding mental retardation in Down's syndrome using trisomy 16 mouse models

31 March 2020

1 reference

Altered long-term potentiation in the young and old Ts65Dn mouse, a model for Down Syndrome.

31 March 2020

1 reference

Synaptic deficit in the temporal cortex of partial trisomy 16 (Ts65Dn) mice.

31 March 2020

1 reference

A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome

31 March 2020

1 reference

Deficits of neuronal density in CA1 and synaptic density in the dentate gyrus, CA3 and CA1, in a mouse model of Down syndrome.

31 March 2020

1 reference

Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome

31 March 2020

1 reference

Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome.

31 March 2020

1 reference

Three-dimensional synaptic ultrastructure in the dentate gyrus and hippocampal area CA3 in the Ts65Dn mouse model of Down syndrome

31 March 2020

1 reference

Early Environmental Stimulation Produces Long-Lasting Changes on β-Adrenoceptor Transduction System

31 March 2020

1 reference

Behavioral assessment of the Ts65Dn mouse, a model for Down syndrome: altered behavior in the elevated plus maze and open field

31 March 2020

1 reference

Motor learning in Ts65Dn mice, a model for Down syndrome.

31 March 2020

1 reference

Impaired sustained attention and error-induced stereotypy in the aged Ts65Dn mouse: a mouse model of Down syndrome and Alzheimer's disease.

31 March 2020

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Impaired short- and long-term memory in Ts65Dn mice, a model for Down syndrome.

31 March 2020

1 reference

Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome.

31 March 2020

1 reference

G-protein-associated signal transduction processes are restored after postweaning environmental enrichment in Ts65Dn, a Down syndrome mouse model

31 March 2020

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Abnormalities of the nucleus basalis in Down's syndrome

31 March 2020

1 reference

Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome.

31 March 2020

1 reference

31 March 2020

1 reference

Effects of chronic administration of SGS-111 during adulthood and during the pre- and post-natal periods on the cognitive deficits of Ts65Dn mice, a model of Down syndrome.

31 March 2020

1 reference

Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome

31 March 2020

1 reference

Rivastigmine in the treatment of dementia in Alzheimer's disease in adults with Down syndrome

31 March 2020

1 reference

Attentional set-shifting in fragile X syndrome.

31 March 2020

1 reference

The functional nature of synaptic circuitry is altered in area CA3 of the hippocampus in a mouse model of Down's syndrome

31 March 2020

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Inhibitory threshold for critical-period activation in primary visual cortex.

31 March 2020

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Cortical plasticity induced by inhibitory neuron transplantation.

31 March 2020

1 reference

Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome.

31 March 2020

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Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome

31 March 2020

1 reference

Developmental neurotransmitters?

31 March 2020

1 reference

Brain plasticity and disease: a matter of inhibition

31 March 2020

1 reference

Is there more to GABA than synaptic inhibition?

31 March 2020

1 reference

Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice

31 March 2020

1 reference

Acute injections of the NMDA receptor antagonist memantine rescue performance deficits of the Ts65Dn mouse model of Down syndrome on a fear conditioning test.

31 March 2020

1 reference

Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome

31 March 2020

1 reference

Memantine normalizes several phenotypic features in the Ts65Dn mouse model of Down syndrome.

31 March 2020

1 reference

The neuroprotective agent memantine induces brain-derived neurotrophic factor and trkB receptor expression in rat brain

31 March 2020

1 reference

Reversal of fragile X phenotypes by manipulation of AβPP/Aβ levels in Fmr1KO mice

31 March 2020

1 reference

Hippocampal hypocellularity in the Ts65Dn mouse originates early in development

31 March 2020

1 reference

Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndrome

31 March 2020

1 reference

Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice

31 March 2020

1 reference

Using mouse models to explore genotype-phenotype relationship in Down syndrome.

31 March 2020

1 reference

MNB/DYRK1A as a multiple regulator of neuronal development

31 March 2020

1 reference

Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling

31 March 2020

1 reference

Dyrk1A overexpression inhibits proliferation and induces premature neuronal differentiation of neural progenitor cells

31 March 2020

1 reference

Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome.

31 March 2020

1 reference

Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A.

31 March 2020

1 reference

Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation

31 March 2020

1 reference

Effect of DYRK1A activity inhibition on development of neuronal progenitors isolated from Ts65Dn mice.

31 March 2020

1 reference

APP processing and synaptic function

31 March 2020

1 reference

Lowering beta-amyloid levels rescues learning and memory in a Down syndrome mouse model

31 March 2020

1 reference

Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome

31 March 2020

1 reference

Trisomy 21 and early brain development

31 March 2020

1 reference

Development and validation of the Arizona Cognitive Test Battery for Down syndrome

31 March 2020

1 reference

Down's syndrome: a genetic disorder in biobehavioral perspective

31 March 2020

1 reference

Transcribed dark matter: meaning or myth?

31 March 2020

1 reference

Trisomy-21 gene dosage over-expression of miRNAs results in the haploinsufficiency of specific target proteins

31 March 2020

1 reference

The piRNA pathway: a fly's perspective on the guardian of the genome.

31 March 2020

1 reference

Chromatin interaction networks and higher order architectures of eukaryotic genomes

31 March 2020

1 reference

Meiotic behavior of aneuploid chromatin in mouse models of Down syndrome.

31 March 2020

1 reference

From abnormal hippocampal synaptic plasticity in down syndrome mouse models to cognitive disability in down syndrome

31 March 2020

1 reference

Functional genomics of Down syndrome: a multidisciplinary approach

31 March 2020

1 reference

12 December 2020

Developmental instability of the cerebellum and its relevance to Down syndrome.

1 reference

12 December 2020

Human intelligence and brain networks.

1 reference

12 December 2020

Growth and development of the brain in Down syndrome

1 reference

12 December 2020

Trafficking the NGF signal: implications for normal and degenerating neurons

1 reference

12 December 2020

The "gene dosage effect" hypothesis versus the "amplified developmental instability" hypothesis in Down syndrome

1 reference

12 December 2020

Gait analysis and cerebral volumes in Down's syndrome.

1 reference

12 December 2020

Segmental trisomy as a mouse model for Down syndrome

1 reference

12 December 2020

The pathology of the human locus ceruleus

1 reference

12 December 2020

Effects of background event rate on sustained attention of mentally retarded and nonretarded adults.

1 reference

12 December 2020

Dyrk1A influences neuronal morphogenesis through regulation of cytoskeletal dynamics in mammalian cortical neurons.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRN3314

1 reference

10 February 2018

1 reference

10 February 2018