(Q48354251)

English

Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment.

scientific article published on 13 January 2017

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scholarly article

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9 April 2020

Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment (English)

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9 April 2020

Andreas Strasser

11

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9 April 2020

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9 April 2020

1

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9 April 2020

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9 April 2020

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9 April 2020

Susanne Heinzel

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9 April 2020

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9 April 2020

9

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9 April 2020

author name string

Emma M Carrington

3

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9 April 2020

Charis E Teh

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9 April 2020

Lin Tai

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9 April 2020

Andreas Villunger

10

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9 April 2020

publication date

13 January 2017

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9 April 2020

Cell Death & Differentiation

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9 April 2020

24

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9 April 2020

3

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9 April 2020

534-545

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9 April 2020

https://scigraph.springernature.com/pub.10.1038/cdd.2016.156

0 references

The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection.

1 reference

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The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

1 reference

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Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis.

1 reference

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18 June 2018

The anti-apoptotic Bcl-2 family protein A1/Bfl-1 regulates neutrophil survival and homeostasis and is controlled via PI3K and JAK/STAT signaling

1 reference

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Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia

1 reference

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18 June 2018

Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival.

1 reference

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18 June 2018

Gene expression profiling of Mycobacterium tuberculosis Lipoarabinomannan-treated macrophages: A role of the Bcl-2 family member A1 in inhibition of apoptosis in mycobacteria-infected macrophages

1 reference

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18 June 2018

Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5344213

18 June 2018

Knockdown of the antiapoptotic Bcl-2 family member A1/Bfl-1 protects mice from anaphylaxis

1 reference

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18 June 2018

Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5344213

18 June 2018

Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5344213

18 June 2018

Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5344213

18 June 2018

Mutually exclusive regulation of T cell survival by IL-7R and antigen receptor-induced signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5344213

18 June 2018

PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5344213

18 June 2018

Possible pitfalls investigating cell death responses in genetically engineered mouse models and derived cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5344213

18 June 2018

Mcl-1 is essential for the survival of plasma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5344213

18 June 2018

Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5344213

18 June 2018

A1/Bfl-1 in leukocyte development and cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5344213

18 June 2018

BCL2A1: the underdog in the BCL2 family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5344213

18 June 2018

Mcl-1 is essential for germinal center formation and B cell memory

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5344213

18 June 2018

Programmed anuclear cell death delimits platelet life span.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5344213

18 June 2018

The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5344213

18 June 2018

Phospholipase Cgamma2 provides survival signals via Bcl2 and A1 in different subpopulations of B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5344213

18 June 2018

Essential role of the prosurvival bcl-2 homologue A1 in mast cell survival after allergic activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5344213

18 June 2018

Conditional deletion of the Bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly

1 reference

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18 June 2018

Apoptosis signaling

1 reference

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18 June 2018

A1 functions at the mitochondria to delay endothelial apoptosis in response to tumor necrosis factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5344213

18 June 2018

Mcl-1 deficiency results in peri-implantation embryonic lethality

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5344213

18 June 2018

NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis

1 reference

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18 June 2018

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

1 reference

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18 June 2018

The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis

1 reference

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18 June 2018

Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant

1 reference

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18 June 2018

Multiple gene duplication and expression of mouse bcl-2-related genes, A1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5344213

18 June 2018

Testicular degeneration in Bclw-deficient mice

1 reference

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18 June 2018

A1, a Bcl-2 family member, prolongs cell survival and permits myeloid differentiation.

1 reference

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A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells

1 reference

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Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1 reference

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Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice

1 reference

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18 June 2018

Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5344213

18 June 2018

bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5344213

18 June 2018

A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5344213

18 June 2018

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5344213

18 June 2018

Characterisation of a novel A1-specific monoclonal antibody.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5344213

14 August 2018

Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5344213

14 August 2018

Overexpression of the antiapoptotic protein A1 promotes the survival of double positive thymocytes awaiting positive selection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5344213

14 August 2018

Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5344213

14 August 2018

Regulation of A1/Bfl-1 expression in peripheral splenic B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5344213

14 August 2018

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5344213

14 August 2018

Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5344213

14 August 2018

A1/Bfl-1 expression is restricted to TCR engagement in T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2016.156

21 January 2018

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2016.156

7 January 2021

based on heuristic

inferred from DOI database lookup

A1 is a growth-permissive antiapoptotic factor mediating postactivation survival in T cells

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2016.156

7 January 2021

based on heuristic

inferred from DOI database lookup

Deficiency in the anti-apoptotic protein A1-a results in a diminished acute inflammatory response

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2016.156

7 January 2021

based on heuristic

inferred from DOI database lookup

Stochastic Model of T Cell Proliferation: A Calculus Revealing IL-2 Regulation of Precursor Frequencies, Cell Cycle Time, and Survival

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2016.156

7 January 2021

based on heuristic

inferred from DOI database lookup

Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2016.156

7 January 2021

based on heuristic

inferred from DOI database lookup

CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2016.156

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/CDD.2016.156

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28085150%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28085150%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28085150%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

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