(Q48406052)

11 February 2018

http://europepmc.org/abstract/MED/25524885

title

Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation (English)

1 reference

11 February 2018

http://europepmc.org/abstract/MED/25524885

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25524885%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Claudio O. Fernandez

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25524885%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Tiago Fleming Outeiro

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25524885%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

author name string

Sybille E Eisbach

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25524885%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Maria Paulat

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25524885%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Karin Giller

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25524885%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Stefan Becker

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25524885%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Markus Zweckstetter

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25524885%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

language of work or name

English

0 references

publication date

19 December 2014

1 reference

11 February 2018

http://europepmc.org/abstract/MED/25524885

published in

Nature Communications

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25524885%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

volume

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25524885%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

issue

1

1 reference

24 June 2019

page(s)

5857

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25524885%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/ncomms6857

12 June 2020

exact match

0 references

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

100 years of Lewy pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Membrane lipid co-aggregation with α-synuclein fibrils.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

α-Synuclein induces both positive mean curvature and negative Gaussian curvature in membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Properties of native brain α-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Large α-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Conformational properties of alpha-synuclein in its free and lipid-associated states

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

The many faces of α-synuclein: from structure and toxicity to therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

A soluble α-synuclein construct forms a dynamic tetramer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

α-Synuclein: membrane interactions and toxicity in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Membrane-bound alpha-synuclein forms an extended helix: long-distance pulsed ESR measurements using vesicles, bicelles, and rodlike micelles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Alpha-synuclein binds large unilamellar vesicles as an extended helix

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Structure and dynamics of micelle-bound human alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Multiple tight phospholipid-binding modes of alpha-synuclein revealed by solution NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Structural organization of alpha-synuclein fibrils studied by site-directed spin labeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

In vivo demonstration that alpha-synuclein oligomers are toxic

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

A century-old debate on protein aggregation and neurodegeneration enters the clinic

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Curcumin prevents aggregation in α-synuclein by increasing reconfiguration rate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Structural and mechanistic basis behind the inhibitory interaction of PcTS on alpha-synuclein amyloid fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Different 8-hydroxyquinolines protect models of TDP-43 protein, α-synuclein, and polyglutamine proteotoxicity through distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Phthalocyanine tetrasulfonates affect the amyloid formation and cytotoxicity of alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Evidence for a partially folded intermediate in alpha-synuclein fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Prophylactic and therapeutic effects of phthalocyanine tetrasulfonate in scrapie-infected mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Tryptophan probes at the alpha-synuclein and membrane interface.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Differential phospholipid binding of alpha-synuclein variants implicated in Parkinson's disease revealed by solution NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Structural intermediates during α-synuclein fibrillogenesis on phospholipid vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

The polyphenol EGCG inhibits amyloid formation less efficiently at phospholipid interfaces than in bulk solution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Phthalocyanine tetrasulfonates bind to multiple sites on natively-folded prion protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

β-synuclein aggregates and induces neurodegeneration in dopaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Secondary structure and dynamics of micelle bound beta- and gamma-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Two different binding modes of α-synuclein to lipid vesicles depending on its aggregation state

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Familial Parkinson mutant alpha-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Dependence of alpha-synuclein aggregate morphology on solution conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Protein secondary structure analyses from circular dichroism spectroscopy: methods and reference databases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

The CCPN data model for NMR spectroscopy: development of a software pipeline

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Measurement of ¹⁵N relaxation rates in perdeuterated proteins by TROSY-based methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Molecular-level secondary structure, polymorphism, and dynamics of full-length alpha-synuclein fibrils studied by solid-state NMR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

The Anti-Parkinsonian Drug Selegiline Delays the Nucleation Phase of α-Synuclein Aggregation Leading to the Formation of Nontoxic Species

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Mapping Long-Range Interactions in α-Synuclein using Spin-Label NMR and Ensemble Molecular Dynamics Simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

Interaction of α-Synuclein with Divalent Metal Ions Reveals Key Differences: A Link between Structure, Binding Specificity and Fibrillation Enhancement

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857

alpha-Synuclein membrane interactions and lipid specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6857