(Q48451250)

11 February 2018

title

p62 Deficiency Enhances α-Synuclein Pathology in Mice (English)

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11 February 2018

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Kunikazu Tanji

1

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11 February 2018

Saori Odagiri

2

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Yasuo Miki

3

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11 February 2018

Atsushi Maruyama

4

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Yoshikazu Nikaido

5

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Junsei Mimura

6

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Fumiaki Mori

7

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Eiji Warabi

8

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Toru Yanagawa

9

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Shinya Ueno

10

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Ken Itoh

11

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Koichi Wakabayashi

12

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publication date

10 October 2014

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11 February 2018

published in

Brain Pathology

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11 February 2018

volume

25

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issue

5

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page(s)

552-564

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p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects.

cites work

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Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies.

21 January 2018

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Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation

21 January 2018

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p62/SQSTM1 differentially removes the toxic mutant androgen receptor via autophagy and inclusion formation in a spinal and bulbar muscular atrophy mouse model.

21 January 2018

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Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of α-synuclein

21 January 2018

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Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein

21 January 2018

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Deficiency of p62/Sequestosome 1 causes hyperphagia due to leptin resistance in the brain.

21 January 2018

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Structural basis for sorting mechanism of p62 in selective autophagy

21 January 2018

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Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

21 January 2018

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Selective autophagy mediated by autophagic adapter proteins

21 January 2018

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LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation

21 January 2018

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alpha-Synucleinopathy models and human neuropathology: similarities and differences

21 January 2018

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D2 dopamine receptor expression and trafficking is regulated through direct interactions with ZIP

21 January 2018

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

21 January 2018

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Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

21 January 2018

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Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies.

21 January 2018

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

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Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

21 January 2018

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Lysosomal degradation of alpha-synuclein in vivo.

21 January 2018

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Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

21 January 2018

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Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter

21 January 2018

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Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

21 January 2018

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Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain

21 January 2018

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Autophagic adapter protein NBR1 is localized in Lewy bodies and glial cytoplasmic inclusions and is involved in aggregate formation in α-synucleinopathy

21 January 2018

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The alpha-glucosidase inhibitor acarbose prevents obesity and simple steatosis in sequestosome 1/A170/p62 deficient mice

21 January 2018

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p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

21 January 2018

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Behavioral characterization of A53T mice reveals early and late stage deficits related to Parkinson's disease.

21 January 2018

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

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Role of hypothalamic proopiomelanocortin neuron autophagy in the control of appetite and leptin response

21 January 2018

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Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration.

21 January 2018

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Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice

21 January 2018

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Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection

21 January 2018

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Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters

21 January 2018

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Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62.

21 January 2018

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Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation

21 January 2018

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TFEB links autophagy to lysosomal biogenesis

21 January 2018

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alpha-Synuclein locus triplication causes Parkinson's disease

21 January 2018

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Alpha-synuclein in Lewy bodies

21 January 2018

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Proteinase K-resistant alpha-synuclein is deposited in presynapses in human Lewy body disease and A53T alpha-synuclein transgenic mice

21 January 2018

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p62/sequestosome 1 binds to TDP-43 in brains with frontotemporal lobar degeneration with TDP-43 inclusions

21 January 2018

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Locomotor hyperactivity and alterations in dopamine neurotransmission are associated with overexpression of A53T mutant human alpha-synuclein in mice

21 January 2018

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α-Synuclein Is Degraded by Both Autophagy and the Proteasome

21 January 2018

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Genetic and pathological links between Parkinson's disease and the lysosomal disorder Sanfilippo syndrome

21 January 2018

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Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/BPA.12214

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11 February 2018

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11 February 2018