(Q48464419)

11 February 2018

title

Characterization of the role of metallothionein-3 in an animal model of Alzheimer's disease. (English)

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11 February 2018

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11 February 2018

Ashley I. Bush

6

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11 February 2018

Juan Hidalgo

8

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11 February 2018

Gabriele Meloni

object named as

Gabriele Meloni

4

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author name string

Yasmina Manso

1

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11 February 2018

Gemma Comes

3

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11 February 2018

Paul A Adlard

5

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11 February 2018

Milan Vašák

7

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11 February 2018

publication date

22 June 2012

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11 February 2018

Cellular and Molecular Life Sciences

published in

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11 February 2018

volume

69

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11 February 2018

issue

21

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11 February 2018

page(s)

3683-3700

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11 February 2018

https://scigraph.springernature.com/pub.10.1007/s00018-012-1047-9

exact match

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cites work

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Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice

21 January 2018

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Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Metallothionein-I and -III expression in animal models of Alzheimer disease.

21 January 2018

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Metallothionein (MT)-III: generation of polyclonal antibodies, comparison with MT-I+II in the freeze lesioned rat brain and in a bioassay with astrocytes, and analysis of Alzheimer's disease brains.

21 January 2018

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Role of metallothionein-III following central nervous system damage.

21 January 2018

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Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice.

21 January 2018

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Role of metallothioneins in peripheral nerve function and regeneration.

21 January 2018

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Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice

21 January 2018

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Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling.

21 January 2018

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21 January 2018

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Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice.

21 January 2018

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The native copper- and zinc-binding protein metallothionein blocks copper-mediated Abeta aggregation and toxicity in rat cortical neurons.

21 January 2018

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Metallothionein-III inhibits initial neurite formation in developing neurons as well as postinjury, regenerative neurite sprouting

21 January 2018

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Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process

21 January 2018

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Abeta peptide immunization restores blood-brain barrier integrity in Alzheimer disease.

21 January 2018

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Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence

21 January 2018

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Zinc release of Zn₇-metallothionein-3 induces fibrillar type amyloid-β aggregates

21 January 2018

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Metallothionein-3 is a component of a multiprotein complex in the mouse brain.

21 January 2018

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Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease.

21 January 2018

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Enhanced neurotrophic activity in Alzheimer's disease cortex is not associated with down-regulation of metallothionein-III (GIF).

21 January 2018

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Factor analysis shows that female rat behaviour is characterized primarily by activity, male rats are driven by sex and anxiety.

21 January 2018

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Interleukin-6 secretion from human astrocytoma cells induced by substance P.

21 January 2018

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Effect of the two conserved prolines of human growth inhibitory factor (metallothionein-3) on its biological activity and structure fluctuation: comparison with a mutant protein.

21 January 2018

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Neuroinflammatory processes in Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Expression of metallothionein-I, -II, and -III in Alzheimer disease and animal models of neuroinflammation.

21 January 2018

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Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Metallothionein-III antagonizes the neurotoxic and neurotrophic effects of amyloid beta peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Anti-amyloid beta activity of metallothionein-III is different from its neuronal growth inhibitory activity: structure-activity studies

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Amyloid-β and tau--a toxic pas de deux in Alzheimer's disease

21 January 2018

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Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19 months.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Progressive and gender-dependent cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer's disease.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Zn7metallothionein-3 and the synaptic vesicle cycle: interaction of metallothionein-3 with the small GTPase Rab3A.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Metallothionein-3 deficient mice exhibit abnormalities of psychological behaviors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Identification of mouse brain proteins associated with isoform 3 of metallothionein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Spatial learning, exploration, anxiety, and motor coordination in female APP23 transgenic mice with the Swedish mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Transgenic mice expressing the betaAPP695SWE mutation: effects on exploratory activity, anxiety, and motor coordination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

A specific amyloid-beta protein assembly in the brain impairs memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Metallothionein and brain inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: implications for Alzheimer beta-amyloid pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Detection of neuronal growth inhibitory factor (metallothionein-3) in polyacrylamide gels and by Western blot analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Metal swap between Zn7-metallothionein-3 and amyloid-beta-Cu protects against amyloid-beta toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Redox activity of α-synuclein-Cu is silenced by Zn₇-metallothionein-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Expression of the gene encoding metallothionein-3 in organs of the reproductive system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Metallothionein-III prevents glutamate and nitric oxide neurotoxicity in primary cultures of cerebellar neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Metal binding of metallothionein-3 versus metallothionein-2: lower affinity and higher plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Rapid exchange of metal between Zn(7)-metallothionein-3 and amyloid-β peptide promotes amyloid-related structural changes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Specificity and divergence in the neurobiologic effects of different metallothioneins after brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

In vivo reduction of amyloid-beta by a mutant copper transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Non-cognitive behaviours in an APP/PS1 transgenic model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Engineering of metallothionein-3 neuroinhibitory activity into the inactive isoform metallothionein-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Copper and clioquinol treatment in young APP transgenic and wild-type mice: effects on life expectancy, body weight, and metal-ion levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Impact of gender differences on the outcome of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Role of oxidative stress in the progression of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Presenilin-2 mutation causes early amyloid accumulation and memory impairment in a transgenic mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Zn(II)- and Cu(II)-induced non-fibrillar aggregates of amyloid-beta (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Whole transcriptome sequencing reveals gene expression and splicing differences in brain regions affected by Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Growth inhibitory factor prevents neurite extension and the death of cortical neurons caused by high oxygen exposure through hydroxyl radical scavenging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Chemistry and biology of mammalian metallothioneins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Preliminary studies on Alzheimer's disease using cDNA microarrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Metallothionein in the central nervous system: Roles in protection, regeneration and cognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Neuroprotection and regeneration by extracellular metallothionein via lipoprotein-receptor-related proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Metallothionein III is reduced in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

Bioactivity of Metallothionein-3 Correlates with Its Novel .beta. Domain Sequence Rather Than Metal Binding Properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1047-9

SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein

21 January 2018

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12 December 2020

Oxidative stress mediates the pathogenic effect of different Alzheimer's disease risk factors

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12 December 2020

Metal removal and substitution in vertebrate and invertebrate metallothioneins

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12 December 2020

Heat shock but not cold shock leads to disturbed intracellular zinc homeostasis

1 reference

12 December 2020

New proteins found interacting with brain metallothionein-3 are linked to secretion

1 reference

12 December 2020

Growth inhibitory factor (GIF) can protect from brain damage due to stab wounds in rat brain

1 reference

12 December 2020

Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles

1 reference

12 December 2020

Reactivity of the Thiol Group in Human and Bovine Albumin at pH 3–9, as Measured by Exchange with 2,2′‐Dithiodipyridine

1 reference

12 December 2020

Toxicity of Alzheimer's disease-associated Aβ peptide is ameliorated in a Drosophila model by tight control of zinc and copper availability.

1 reference

12 December 2020

Histochemically reactive zinc in plaques of the Swedish mutant beta-amyloid precursor protein transgenic mice.

1 reference

12 December 2020

Expression of human metallothionein-III in transgenic mice

1 reference

12 December 2020

Castration- and aging-induced changes in the expression of zinc transporter and metallothionein in rat prostate

1 reference

12 December 2020

Metals and Alzheimer's disease

1 reference

12 December 2020

Evidence for a dynamic structure of human neuronal growth inhibitory factor and for major rearrangements of its metal-thiolate clusters

1 reference

12 December 2020

Expression and regulation of metallothioneins in the rat epididymis

1 reference

12 December 2020

Molecular cloning of human growth inhibitory factor cDNA and its down-regulation in Alzheimer's disease

1 reference

12 December 2020

Disruption of the metallothionein-III gene in mice: analysis of brain zinc, behavior, and neuron vulnerability to metals, aging, and seizures.

1 reference

12 December 2020

Disease progression in a transgenic model of familial amyotrophic lateral sclerosis is dependent on both neuronal and non-neuronal zinc binding proteins

1 reference

12 December 2020

10.1007/S00018-012-1047-9

Identifiers

DOI

1 reference

11 February 2018

PubMed ID

22722772

1 reference

11 February 2018