(Q48572492)

12 February 2018

title

Down-Regulation of Excitatory Amino Acid Transporters EAAT1 and EAAT2 by the Kinases SPAK and OSR1. (English)

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12 February 2018

author

Bernat Elvira

3

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12 February 2018

author name string

Abeer Abousaab

1

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12 February 2018

Jamshed Warsi

2

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12 February 2018

Ioana Alesutan

4

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12 February 2018

Zohreh Hoseinzadeh

5

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12 February 2018

Florian Lang

6

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12 February 2018

publication date

2 August 2015

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12 February 2018

Journal of Membrane Biology

published in

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12 February 2018

volume

248

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12 February 2018

issue

6

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12 February 2018

page(s)

1107-1119

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12 February 2018

https://scigraph.springernature.com/pub.10.1007/s00232-015-9826-5

exact match

0 references

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Comparative analysis of glutamate transporter expression in rat brain using differential double in situ hybridization

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Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B

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Post-translational regulation of EAAT2 function by co-expressed ubiquitin ligase Nedd4-2 is impacted by SGK kinases.

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Hypoxia suppresses astrocyte glutamate transport independently of amyloid formation

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21 January 2018

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21 January 2018

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21 January 2018

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SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells

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Down-regulation of the Na+-coupled phosphate transporter NaPi-IIa by AMP-activated protein kinase.

21 January 2018

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Glutamate transporter EAAT2 expression is up-regulated in reactive astrocytes in human periventricular leukomalacia.

21 January 2018

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21 January 2018

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Identification of regulatory phosphorylation sites in a cell volume- and Ste20 kinase-dependent ClC anion channel

21 January 2018

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C. elegans STK39/SPAK ortholog-mediated inhibition of ClC anion channel activity is regulated by WNK-independent ERK kinase signaling

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Negative regulation of the creatine transporter SLC6A8 by SPAK and OSR1

21 January 2018

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Cotransporters, WNKs and hypertension: an update

21 January 2018

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Glutamate transporters and the excitotoxic path to motor neuron degeneration in amyotrophic lateral sclerosis

21 January 2018

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Down-regulated expression of glutamate transporter GLAST in Purkinje cell-associated astrocytes of reeler and weaver mutant cerebella

21 January 2018

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21 January 2018

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Immunocytochemical localization of a high-affinity glutamate-aspartate transporter, GLAST, in the rat and guinea-pig cochlea

21 January 2018

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On the substrate recognition and negative regulation of SPAK, a kinase modulating Na+-K+-2Cl- cotransport activity

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Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport

21 January 2018

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21 January 2018

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Regulation of the glutamate transporter EAAT2 by PIKfyve

21 January 2018

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A caspase-3-cleaved fragment of the glial glutamate transporter EAAT2 is sumoylated and targeted to promyelocytic leukemia nuclear bodies in mutant SOD1-linked amyotrophic lateral sclerosis

21 January 2018

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Molecular mechanisms and regulation of furosemide-sensitive Na-K-Cl cotransporters.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

SPAK and WNK kinases: a new target for blood pressure treatment?

21 January 2018

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Hypertension, dietary salt intake, and the role of the thiazide-sensitive sodium chloride transporter NCCT.

21 January 2018

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Glutamate does not play a major role in controlling bone growth

21 January 2018

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Ion channels involved in cell volume regulation: effects on migration, proliferation, and programmed cell death in non adherent EAT cells and adherent ELA cells

21 January 2018

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Physiology of cell volume regulation in vertebrates.

21 January 2018

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21 January 2018

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Downregulation of KCNQ4 by Janus kinase 2.

21 January 2018

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Down-regulation of the epithelial Na⁺ channel ENaC by Janus kinase 2.

21 January 2018

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Mechanism of regulation of renal ion transport by WNK kinases

21 January 2018

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The open reading frame of the Na(+)-dependent glutamate transporter GLAST-1 is expressed in bone and a splice variant of this molecule is expressed in bone and brain.

21 January 2018

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Delayed post-ischemic administration of CDP-choline increases EAAT2 association to lipid rafts and affords neuroprotection in experimental stroke.

21 January 2018

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Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases

21 January 2018

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Loss of glial glutamate and aspartate transporter (excitatory amino acid transporter 1) causes locomotor hyperactivity and exaggerated responses to psychotomimetics: rescue by haloperidol and metabotropic glutamate 2/3 agonist

21 January 2018

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Assessment of glutamate transporter GLAST (EAAT1)-deficient mice for phenotypes relevant to the negative and executive/cognitive symptoms of schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Characterization of Na+-coupled glutamate/aspartate transport by a rat brain astrocyte line expressing GLAST and EAAC1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Mechanisms and significance of cell volume regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Molecular mechanisms of schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Localization of the glutamate-aspartate transporter, GLAST, in rat taste buds

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Localization, transport, and uptake of D-aspartate in the rat adrenal and pituitary glands

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Identification of a glutamate/aspartate transporter in the rat cochlea

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Mechanically regulated expression of a neural glutamate transporter in bone: a role for excitatory amino acids as osteotropic agents?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

The -181 A/C polymorphism in the excitatory amino acid transporter-2 gene promoter affects the personality trait of reward dependence in healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Role of SPAK and OSR1 signalling in the regulation of NaCl cotransporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Expression of the glial glutamate transporter EAAT2 in the human CNS: an immunohistochemical study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Differential regulation of a CLC anion channel by SPAK kinase ortholog-mediated multisite phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Chemical hypoxia facilitates alternative splicing of EAAT2 in presymptomatic APP23 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Up-regulation of the inwardly rectifying K⁺ channel Kir2.1 (KCNJ2) by protein kinase B (PKB/Akt) and PIKfyve

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Molecular events caused by mechanical stress in bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

WNK1, a Gene within a Novel Blood Pressure Control Pathway, Tissue-Specifically Generates Radically Different Isoforms with and without a Kinase Domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

PIKfyve sensitivity of hERG channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Association of an EAAT2 polymorphism with higher glutamate concentration in relapsing multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Dynamic regulation of CFTR bicarbonate permeability by [Cl-]i and its role in pancreatic bicarbonate secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

OSR1-sensitive renal tubular phosphate reabsorption.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Role of the WNK-activated SPAK kinase in regulating blood pressure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Activity-dependent gene expression correlates with interictal spiking in human neocortical epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Localization of neuronal and glial glutamate transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Ceftriaxone protects against the neurotoxicity of human immunodeficiency virus proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Characterization of astrocytes derived from human NTera-2/D1 embryonal carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Effects of threo-beta-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Discrete cellular and subcellular localization of glutamine synthetase and the glutamate transporter GLAST in the rat vestibular end organ

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Pathophysiological roles of WNK kinases in the kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Differential developmental expression of the two rat brain glutamate transporter proteins GLAST and GLT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Differential expression patterns of three glutamate transporters (GLAST, GLT1 and EAAC1) in the rat main olfactory bulb

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Decreased expression of glutamate transporters in astrocytes after human traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Structure of the OSR1 kinase, a hypertension drug target

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

SPAK dependent regulation of peptide transporters PEPT1 and PEPT2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Downregulation of peptide transporters PEPT1 and PEPT2 by oxidative stress responsive kinase OSR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Regulation of ClC-2 activity by SPAK and OSR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Human hypertension caused by mutations in WNK kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Translational Control of Glial Glutamate Transporter EAAT2 Expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Expression of glutamate transporters in rat optic nerve oligodendrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-015-9826-5

Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B.

21 January 2018

1 reference

12 December 2020

Altered Glutamate Reuptake in Relapsing-Remitting and Secondary Progressive Multiple Sclerosis Cortex: Correlation With Microglia Infiltration, Demyelination, and Neuronal and Synaptic Damage

1 reference

12 December 2020

Coincidence of L-glutamate/L-aspartate transporter (GLAST) and glutamine synthetase (GS) immunoreactions in retinal glia: evidence for coupling of GLAST and GS in transmitter clearance

1 reference

12 December 2020

Antisense knockdown of GLAST, a glial glutamate transporter, compromises retinal function.

1 reference

12 December 2020

Transient expression of the glial glutamate transporters GLAST and GLT in hippocampal neurons in primary culture

1 reference

12 December 2020

Cellular interplay between neurons and glia: toward a comprehensive mechanism for excitotoxic neuronal loss in neurodegeneration

1 reference

12 December 2020

Immunohistochemical study of the glutamate transporter proteins GLT-1 and GLAST in rat and gerbil pineal gland

1 reference

12 December 2020

Focal reduction of neuronal glutamate transporters in human neocortical epilepsy

1 reference

12 December 2020

Modulation of glutamate transporters (GLAST, GLT-1 and EAAC1) in the rat cerebellum following portocaval anastomosis

1 reference

12 December 2020

Transient upregulation of the glial glutamate transporter GLAST in response to fibroblast growth factor, insulin-like growth factor and epidermal growth factor in cultured astrocytes.

1 reference

12 December 2020

Depression of retinal glutamate transporter function leads to elevated intravitreal glutamate levels and ganglion cell death

1 reference

12 December 2020

The number of glutamate transporter subtype molecules at glutamatergic synapses: chemical and stereological quantification in young adult rat brain

1 reference

12 December 2020

Glutamate transporter alterations in Alzheimer disease are possibly associated with abnormal APP expression.

1 reference

12 December 2020

10.1007/S00232-015-9826-5

Identifiers

DOI

1 reference

12 February 2018

1 reference

12 February 2018