(Q48897393)

English

Ubiquitin is associated with early truncation of tau protein at aspartic acid(421) during the maturation of neurofibrillary tangles in Alzheimer's disease.

scientific article published on 12 October 2011

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

16 February 2018

http://europepmc.org/abstract/MED/21919991

Ubiquitin is associated with early truncation of tau protein at aspartic acid(421) during the maturation of neurofibrillary tangles in Alzheimer's disease. (English)

1 reference

Europe PubMed Central

16 February 2018

http://europepmc.org/abstract/MED/21919991

Alzheimer's disease

0 references

author name string

Francisco García-Sierra

1

1 reference

Europe PubMed Central

16 February 2018

http://europepmc.org/abstract/MED/21919991

Jose J Jarero-Basulto

2

1 reference

Europe PubMed Central

16 February 2018

http://europepmc.org/abstract/MED/21919991

Zdena Kristofikova

3

1 reference

Europe PubMed Central

16 February 2018

http://europepmc.org/abstract/MED/21919991

Emerich Majer

4

1 reference

Europe PubMed Central

16 February 2018

http://europepmc.org/abstract/MED/21919991

Lester I Binder

5

1 reference

Europe PubMed Central

16 February 2018

http://europepmc.org/abstract/MED/21919991

Daniela Ripova

6

1 reference

Europe PubMed Central

16 February 2018

http://europepmc.org/abstract/MED/21919991

publication date

12 October 2011

1 reference

Europe PubMed Central

16 February 2018

http://europepmc.org/abstract/MED/21919991

Brain Pathology

1 reference

Europe PubMed Central

16 February 2018

http://europepmc.org/abstract/MED/21919991

22

1 reference

Europe PubMed Central

16 February 2018

http://europepmc.org/abstract/MED/21919991

2

1 reference

Europe PubMed Central

16 February 2018

http://europepmc.org/abstract/MED/21919991

240-250

1 reference

Europe PubMed Central

16 February 2018

http://europepmc.org/abstract/MED/21919991

Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Phosphorylation of tau at Thr212, Thr231, and Ser262 combined causes neurodegeneration

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Proteasome-caspase-cathepsin sequence leading to tau pathology induced by prostaglandin J2 in neuronal cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia. A quantitative study

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Tau paired helical filaments from Alzheimer's disease brain and assembled in vitro are based on beta-structure in the core domain

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Accumulation of aspartic acid421- and glutamic acid391-cleaved tau in neurofibrillary tangles correlates with progression in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Alzheimer's disease: intraneuronal alterations precede insoluble amyloid-beta formation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

A68 proteins in Alzheimer's disease are composed of several tau isoforms in a phosphorylated state which affects their electrophoretic mobilities

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

From tau phosphorylation to tau aggregation: what about neuronal death?

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

The structural basis of monoclonal antibody Alz50's selectivity for Alzheimer's disease pathology.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Ubiquitin immunochemistry as a diagnostic aid for community pathologists evaluating patients who have dementia.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Proapoptotic effects of tau cleavage product generated by caspase-3.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Polyubiquitin linkage profiles in three models of proteolytic stress suggest the etiology of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Protein quality control in Alzheimer's disease by the ubiquitin proteasome system.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Proteasome inhibition and Tau proteolysis: an unexpected regulation.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Site-specific phosphorylation and caspase cleavage differentially impact tau-microtubule interactions and tau aggregation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

The neuronal microtubule-associated protein tau is a substrate for caspase-3 and an effector of apoptosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Tau is not normally degraded by the proteasome

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Accumulation of C-terminally truncated tau protein associated with vulnerability of the perforant pathway in early stages of neurofibrillary pathology in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Tau-66: evidence for a novel tau conformation in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Tau truncation during neurofibrillary tangle evolution in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Transcriptional and conformational changes of the tau molecule in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Alzheimer neurofibrillary degeneration: significance, etiopathogenesis, therapeutics and prevention

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Epitopes that span the tau molecule are shared with paired helical filaments.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Alzheimer disease proteins (A68) share epitopes with tau but show distinct biochemical properties

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

The primary structure and heterogeneity of tau protein from mouse brain.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

The ubiquitin proteasome system in neuropathology

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Phosphorylation-dependent epitopes of neurofilament antibodies on tau protein and relationship with Alzheimer tau

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Thiazin red as a neuropathological tool for the rapid diagnosis of Alzheimer's disease in tissue imprints.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

On the structure of microtubules, tau, and paired helical filaments

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Tau domains, phosphorylation, and interactions with microtubules.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Ubiquitin is associated with abnormal cytoplasmic filaments characteristic of neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Monitoring pathological assembly of tau and beta-amyloid proteins in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Ubiquitin is a component of paired helical filaments in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Difference between the tau protein of Alzheimer paired helical filament core and normal tau revealed by epitope analysis of monoclonal antibodies 423 and 7.51

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

The ubiquitin-proteasome system in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Caspase-cleaved tau expression induces mitochondrial dysfunction in immortalized cortical neurons: implications for the pathogenesis of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Alpha-helix structure in Alzheimer's disease aggregates of tau-protein.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Targeting proteins for destruction by the ubiquitin system: implications for human pathobiology

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

CHIP-Hsc70 Complex Ubiquitinates Phosphorylated Tau and Enhances Cell Survival

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Pseudohyperphosphorylation causing AD-like changes in tau has significant effects on its polymerization

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Ultrastructural localization of beta-amyloid, tau, and ubiquitin epitopes in extracellular neurofibrillary tangles

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Ubiquitin, the proteasome and protein degradation in neuronal function and dysfunction

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Relationship between plaques, tangles, and dystrophic processes in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Role of the ubiquitin proteasome system in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

ATP-induced loss of Alz-50 immunoreactivity with the A68 proteins from Alzheimer brain is mediated by ubiquitin

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Structural characterization of the core of the paired helical filament of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Quantitative analysis of tau protein in paired helical filament preparations: implications for the role of tau protein phosphorylation in PHF assembly in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

C-terminal truncation modulates both nucleation and extension phases of tau fibrillization

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Hyperphosphorylation of microtubule-associated tau protein plays dual role in neurodegeneration and neuroprotection

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Immunochemical Properties of Ubiquitin Conjugates in the Paired Helical Filaments of Alzheimer Disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Phosphorylation modulates the local conformation and self-aggregation ability of a peptide from the fourth tau microtubule-binding repeat

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00525.X

21 January 2018

Identifiers

10.1111/J.1750-3639.2011.00525.X

1 reference

Europe PubMed Central

16 February 2018

http://europepmc.org/abstract/MED/21919991

1 reference

Europe PubMed Central

16 February 2018

http://europepmc.org/abstract/MED/21919991

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q48897393&oldid=1233688711"