(Q49307514)

19 February 2018

title

Dysregulated metabolic enzymes and metabolic reprogramming in cancer cells. (English)

1 reference

19 February 2018

author name string

Annapoorna Sreedhar

series ordinal

1

1 reference

19 February 2018

Yunfeng Zhao

series ordinal

2

1 reference

19 February 2018

publication date

21 November 2017

1 reference

19 February 2018

published in

Biomedical Reports

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19 February 2018

volume

8

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19 February 2018

issue

1

1 reference

19 February 2018

page(s)

3-10

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19 February 2018

Inhibition of FASN suppresses migration, invasion and growth in hepatoma carcinoma cells by deregulating the HIF-1α/IGFBP1 pathway

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22 May 2018

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22 May 2018

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ATP citrate lyase expression is associated with advanced stage and prognosis in gastric adenocarcinoma

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Metabolomic profile of glycolysis and the pentose phosphate pathway identifies the central role of glucose-6-phosphate dehydrogenase in clear cell-renal cell carcinoma

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Metabolic effect of TAp63α: enhanced glycolysis and pentose phosphate pathway, resulting in increased antioxidant defense

22 May 2018

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Defects in mitochondrial metabolism and cancer

22 May 2018

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The pentose phosphate pathway and cancer

22 May 2018

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Regulation of the pentose phosphate pathway in cancer

22 May 2018

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Association between phosphorylated AMP-activated protein kinase and acetyl-CoA carboxylase expression and outcome in patients with squamous cell carcinoma of the head and neck

22 May 2018

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Serine and glycine metabolism in cancer

22 May 2018

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Metabolic requirements for the maintenance of self-renewing stem cells

22 May 2018

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Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cancer: recognition of the syndrome by pathologic features and the utility of detecting aberrant succination by immunohistochemistry.

22 May 2018

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Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development

22 May 2018

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Is cancer a metabolic disease?

22 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Glutamine and cancer: cell biology, physiology, and clinical opportunities

22 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Aberrant overexpression of pyruvate kinase M2 is associated with aggressive tumor features and the BRAF mutation in papillary thyroid cancer

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Serine, glycine and one-carbon units: cancer metabolism in full circle

22 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Cellular fatty acid metabolism and cancer

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Cancer metabolism: fatty acid oxidation in the limelight

22 May 2018

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Deregulation of glycolysis in cancer: glyceraldehyde-3-phosphate dehydrogenase as a therapeutic target

22 May 2018

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Targeting cancer cell mitochondria as a therapeutic approach

22 May 2018

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Cellular and molecular mechanisms of mitochondrial function

22 May 2018

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22 May 2018

Mitochondria and cancer

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TCA Cycle Defects and Cancer: When Metabolism Tunes Redox State

22 May 2018

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Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation

22 May 2018

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Lipid metabolism in cancer

22 May 2018

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The pentose phosphate pathway: an antioxidant defense and a crossroad in tumor cell fate

22 May 2018

1 reference

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Links between metabolism and cancer

22 May 2018

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Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Enhancing mitochondrial respiration suppresses tumor promoter TPA-induced PKM2 expression and cell transformation in skin epidermal JB6 cells.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Hallmarks of Cancer: The Next Generation

22 May 2018

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Respiratory chain complex I deficiency caused by mitochondrial DNA mutations

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Regulation of cancer cell metabolism

22 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Androgen stimulates glycolysis for de novo lipid synthesis by increasing the activities of hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 in prostate cancer cells.

22 May 2018

1 reference

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Glutamine addiction: a new therapeutic target in cancer

22 May 2018

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Differential expression of phosphofructokinase-1 isoforms correlates with the glycolytic efficiency of breast cancer cells

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Cancer as a metabolic disease

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

22 May 2018

1 reference

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Small mitochondria-targeting molecules as anti-cancer agents

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

22 May 2018

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Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

22 May 2018

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Expression of glutamate receptor subunits in human cancers

22 May 2018

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

22 May 2018

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IDH1 and IDH2 mutations in gliomas

22 May 2018

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Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

22 May 2018

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Is cancer a disease of abnormal cellular metabolism? New angles on an old idea

22 May 2018

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Glycine regulates the production of pro-inflammatory cytokines in lean and monosodium glutamate-obese mice

22 May 2018

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An integrated genomic analysis of human glioblastoma multiforme

22 May 2018

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ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis

22 May 2018

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Brick by brick: metabolism and tumor cell growth

22 May 2018

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The mitochondrial respiratory chain is a modulator of apoptosis.

22 May 2018

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Functions and dysfunctions of mitochondrial dynamics

22 May 2018

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The physiological role of biogenic amines redox reactions in mitochondria. New perspectives in cancer therapy.

22 May 2018

1 reference

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Glycolysis inhibition for anticancer treatment

22 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Mitochondria: more than just a powerhouse

22 May 2018

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Mitochondrial aconitase and citrate metabolism in malignant and nonmalignant human prostate tissues

22 May 2018

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Proteome analysis of human lung squamous carcinoma

22 May 2018

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Polyamines and apoptosis.

22 May 2018

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ATP citrate lyase is an important component of cell growth and transformation

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Mitochondrial DNA mutations in human disease

22 May 2018

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Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations

22 May 2018

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The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase.

22 May 2018

1 reference

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On the Origin of Cancer Cells

22 May 2018

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Mutations in the fumarate hydratase gene cause hereditary leiomyomatosis and renal cell cancer in families in North America

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Mitochondria: releasing power for life and unleashing the machineries of death

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Mitochondrial defects in cancer

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

The expanding role of mitochondria in apoptosis

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

PFK-2/FBPase-2: maker and breaker of the essential biofactor fructose-2,6-bisphosphate.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Facile detection of mitochondrial DNA mutations in tumors and bodily fluids

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Inborn errors of the Krebs cycle: a group of unusual mitochondrial diseases in human

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Glucose catabolism in cancer cells: amplification of the gene encoding type II hexokinase

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Transcriptional regulation of the Saccharomyces cerevisiae HXK1, HXK2 and GLK1 genes.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Increased glyceraldehyde-3-phosphate dehydrogenase gene expression in human pancreatic adenocarcinoma.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Increased activity of 6-phosphogluconate dehydrogenase and glucose-6-phosphate dehydrogenase in purified cell suspensions and single cells from the uterine cervix in cervical intraepithelial neoplasia

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

High aerobic glycolysis of rat hepatoma cells in culture: Role of mitochondrial hexokinase

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Glutaminolysis activates Rag-mTORC1 signaling.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Glutaminolysis: supplying carbon or nitrogen or both for cancer cells?

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Glycine treatment decreases proinflammatory cytokines and increases interferon-gamma in patients with type 2 diabetes

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Cellular distribution of phosphofructokinase activity and implications to metabolic regulation in human breast cancer.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Reduced expression and loss of heterozygosity of the SDHD gene in colorectal and gastric cancer.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Characterization of Hex2 protein, a negative regulatory element necessary for glucose repression in yeast.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772474

Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases

14 August 2018

1 reference

12 December 2020

Enhanced expression of a glyceraldehyde-3-phosphate dehydrogenase gene in human lung cancers

1 reference

12 December 2020

Purification and characterization of a novel xylulose 5-phosphate-activated protein phosphatase catalyzing dephosphorylation of fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase

1 reference

12 December 2020

Association of glyceraldehyde-3-phosphate dehydrogenase expression with cell motility and metastatic potential of rat prostatic adenocarcinoma

1 reference

12 December 2020

Nitric oxide induces and inhibits apoptosis through different pathways

1 reference

12 December 2020

Nuclear and mitochondrial genome instability in human breast cancer

1 reference

12 December 2020

High incidence of somatic mitochondrial DNA mutations in human ovarian carcinomas

1 reference

12 December 2020

Comprehensive scanning of somatic mitochondrial DNA mutations in breast cancer

1 reference

12 December 2020

Fatty acid synthase overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype

1 reference

12 December 2020

Cysteine, histidine and glycine exhibit anti-inflammatory effects in human coronary arterial endothelial cells

1 reference

12 December 2020

Identifiers

DOI

10.3892/BR.2017.1022

1 reference

19 February 2018

PMCID

5772474

1 reference

19 February 2018

PubMed ID

29399334

1 reference

19 February 2018