(Q50053868)

English

Pharmacogenetic effects of regulatory nuclear receptors (PXR, CAR, RXRα and HNF4α) on docetaxel disposition in Chinese nasopharyngeal cancer patients.

scientific article published on 6 November 2013

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/24193570

Pharmacogenetic effects of regulatory nuclear receptors (PXR, CAR, RXRα and HNF4α) on docetaxel disposition in Chinese nasopharyngeal cancer patients. (English)

1 reference

Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/24193570

1 reference

based on heuristic

inferred from title

author name string

Sin-Chi Chew

1

1 reference

Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/24193570

Joanne Lim

2

1 reference

Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/24193570

Onkar Singh

3

1 reference

Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/24193570

Xiangai Chen

4

1 reference

Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/24193570

Eng-Huat Tan

5

1 reference

Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/24193570

Edmund-J D Lee

6

1 reference

Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/24193570

Balram Chowbay

7

1 reference

Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/24193570

publication date

6 November 2013

1 reference

Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/24193570

European Journal of Clinical Pharmacology

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Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/24193570

70

1 reference

Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/24193570

2

1 reference

Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/24193570

155-166

1 reference

Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/24193570

https://scigraph.springernature.com/pub.10.1007/s00228-013-1596-3

0 references

Factors affecting pharmacokinetic variability following doxorubicin and docetaxel-based therapy.

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21 January 2018

Identification of OATP1B3 as a high-affinity hepatocellular transporter of paclitaxel

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21 January 2018

Influence of SLCO1B3 haplotype-tag SNPs on docetaxel disposition in Chinese nasopharyngeal cancer patients

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21 January 2018

Induction of phase I, II and III drug metabolism/transport by xenobiotics

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The induction of cytochrome P450 3A5 (CYP3A5) in the human liver and intestine is mediated by the xenobiotic sensors pregnane X receptor (PXR) and constitutively activated receptor (CAR).

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21 January 2018

Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs

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21 January 2018

The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4

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21 January 2018

PXR pharmacogenetics: association of haplotypes with hepatic CYP3A4 and ABCB1 messenger RNA expression and doxorubicin clearance in Asian breast cancer patients

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21 January 2018

Genetic variations of NR2A1 in Asian populations: implications in pharmacogenetics studies.

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Genetic variations of NR1I3 and NR2B1 in Asian populations

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The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants

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21 January 2018

Docetaxel is effective in heavily pretreated patients with disseminated nasopharyngeal carcinoma.

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21 January 2018

TAGster: efficient selection of LD tag SNPs in single or multiple populations.

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Novel single nucleotide polymorphisms in the promoter and intron 1 of human pregnane X receptor/NR1I2 and their association with CYP3A4 expression

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21 January 2018

PXR, CAR and HNF4alpha genotypes and their association with pharmacokinetics and pharmacodynamics of docetaxel and doxorubicin in Asian patients.

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21 January 2018

Population pharmacokinetic modeling of the association between 63396C->T pregnane X receptor polymorphism and unboosted atazanavir clearance

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21 January 2018

Association of a single nucleotide polymorphism in the constitutive androstane receptor gene with bone mineral density

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21 January 2018

Genetic polymorphisms in vitamin D receptor VDR/RXRA influence the likelihood of colon adenoma recurrence

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21 January 2018

Genetic variation in the retinoid X receptor and calcium-sensing receptor and risk of colorectal cancer in the Colon Cancer Family Registry.

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21 January 2018

Genetic variants in peroxisome proliferator-activated receptor-γ and retinoid X receptor-α gene and type 2 diabetes risk: a case-control study of a Chinese Han population.

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21 January 2018

Analysis of SNPs and haplotypes in vitamin D pathway genes and renal cancer risk

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21 January 2018

Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects

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21 January 2018

Genetic polymorphism of hepatocyte nuclear factor-4alpha influences human cytochrome P450 2D6 activity

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21 January 2018

The DNA binding domain of hepatocyte nuclear factor 4 mediates cooperative, specific binding to DNA and heterodimerization with the retinoid X receptor alpha

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21 January 2018

A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 alpha gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an ashkenazi jewish population.

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21 January 2018

A systematic analysis of the 3'UTR of HNF4A mRNA reveals an interplay of regulatory elements including miRNA target sites

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21 January 2018

In silico and in vitro identification of microRNAs that regulate hepatic nuclear factor 4α expression

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21 January 2018

Haploview: analysis and visualization of LD and haplotype maps

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21 January 2018

The structure of haplotype blocks in the human genome

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21 January 2018

PLINK: a tool set for whole-genome association and population-based linkage analyses

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21 January 2018

WHAP: haplotype-based association analysis

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21 January 2018

Investigation of a genome wide association signal for obesity: synthetic association and haplotype analyses at the melanocortin 4 receptor gene locus

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21 January 2018

Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention

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21 January 2018

RXRA gene variations influence Alzheimer's disease risk and cholesterol metabolism

1 reference

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A miR-24 microRNA binding-site polymorphism in dihydrofolate reductase gene leads to methotrexate resistance

1 reference

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21 January 2018

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

1 reference

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21 January 2018

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

1 reference

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Practical aspects of weekly docetaxel administration schedules

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21 January 2018

Comparative adverse effect profiles of platinum drugs.

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Prospective randomized trial of docetaxel versus doxorubicin in patients with metastatic breast cancer.

1 reference

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Role of human cytochrome P450 3A4 and 3A5 in the metabolism of taxotere and its derivatives: enzyme specificity, interindividual distribution and metabolic contribution in human liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/24193570

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Pharmacogenetic screening of CYP3A and ABCB1 in relation to population pharmacokinetics of docetaxel

1 reference

https://pubmed.ncbi.nlm.nih.gov/24193570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sensitive determination of docetaxel in human plasma by liquid-liquid extraction and reversed-phase high-performance liquid chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/24193570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of CYP3A4, CYP3A5, ABCB1, ABCC2, ABCG2 and SLCO1B3 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of docetaxel in nasopharyngeal carcinoma patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/24193570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multifactor dimensionality reduction: an analysis strategy for modelling and detecting gene-gene interactions in human genetics and pharmacogenomics studies

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24193570

12 December 2020

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Association of novel variants in the hepatocyte nuclear factor 4A gene with maturity onset diabetes of the young and early onset type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24193570

12 December 2020

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inferred from PubMed ID database lookup

Orphan nuclear receptors: from gene to function

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

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1 reference

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T130I mutation in HNF-4alpha gene is a loss-of-function mutation in hepatocytes and is associated with late-onset Type 2 diabetes mellitus in Japanese subjects

1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/24193570

12 December 2020

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inferred from PubMed ID database lookup

Identifiers

10.1007/S00228-013-1596-3

1 reference

Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/24193570

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/24193570

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