(Q50056637)

30 June 2019

title

Inflammasome, Inflammation, and Tissue Homeostasis. (English)

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30 June 2019

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Vijay A K Rathinam

1

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30 June 2019

Francis Ka-Ming Chan

series ordinal

2

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30 June 2019

publication date

9 February 2018

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30 June 2019

Trends in Molecular Medicine

published in

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30 June 2019

volume

24

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30 June 2019

issue

3

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30 June 2019

page(s)

304-318

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30 June 2019

HNPCC-associated small bowel cancer: clinical and molecular characteristics

cites work

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12 December 2020

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

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12 December 2020

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

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12 December 2020

Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome.

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12 December 2020

Pseudomonas aeruginosa activates caspase 1 through Ipaf

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12 December 2020

Active caspase-1 is a regulator of unconventional protein secretion

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12 December 2020

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production

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12 December 2020

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

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12 December 2020

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

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12 December 2020

Coding microsatellite instability analysis in microsatellite unstable small intestinal adenocarcinomas identifies MARCKS as a common target of inactivation.

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12 December 2020

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

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12 December 2020

Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome

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12 December 2020

The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis

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12 December 2020

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

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12 December 2020

The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

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12 December 2020

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

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12 December 2020

IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation

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12 December 2020

The Nlrp3 inflammasome: contributions to intestinal homeostasis

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12 December 2020

Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22.

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12 December 2020

Genetic association between NLRP3 variants and Crohn's disease does not replicate in a large UK panel

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12 December 2020

NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis

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12 December 2020

Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury

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12 December 2020

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

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12 December 2020

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus.

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12 December 2020

Non-canonical inflammasome activation targets caspase-11

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12 December 2020

Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.

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12 December 2020

Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota

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12 December 2020

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

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12 December 2020

Protective and aggravating effects of Nlrp3 inflammasome activation in IBD models: influence of genetic and environmental factors

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12 December 2020

Tricking the guard: exploiting plant defense for disease susceptibility

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12 December 2020

Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome.

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12 December 2020

Caspase-11 protects against bacteria that escape the vacuole

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12 December 2020

Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid

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12 December 2020

Noncanonical inflammasome activation by intracellular LPS independent of TLR4.

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12 December 2020

Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis

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12 December 2020

Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation

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12 December 2020

Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock

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12 December 2020

NLRC4 expression in intestinal epithelial cells mediates protection against an enteric pathogen.

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12 December 2020

Nlrp3 activation in the intestinal epithelium protects against a mucosal pathogen

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12 December 2020

NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion

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12 December 2020

Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes

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12 December 2020

Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation

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12 December 2020

Lack of Absent in Melanoma 2 (AIM2) expression in tumor cells is closely associated with poor survival in colorectal cancer patients

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12 December 2020

Caspase-11 is expressed in the colonic mucosa and protects against dextran sodium sulfate-induced colitis

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12 December 2020

The inflammasome pyrin contributes to pertussis toxin-induced IL-1β synthesis, neutrophil intravascular crawling and autoimmune encephalomyelitis

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12 December 2020

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

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12 December 2020

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

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12 December 2020

CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22.

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12 December 2020

Inflammatory caspases are innate immune receptors for intracellular LPS.

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12 December 2020

Epithelium-intrinsic NAIP/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa

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12 December 2020

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

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12 December 2020

Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation

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12 December 2020

Regional specialization within the intestinal immune system

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12 December 2020

Regulated cell death and inflammation: an auto-amplification loop causes organ failure

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12 December 2020

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12 December 2020

The necroptosis adaptor RIPK3 promotes injury-induced cytokine expression and tissue repair

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12 December 2020

Role of inflammasomes in intestinal inflammation and Crohn's disease

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12 December 2020

Protective role for caspase-11 during acute experimental murine colitis

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12 December 2020

A RIPK3-caspase 8 complex mediates atypical pro-IL-1β processing

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12 December 2020

UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis

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12 December 2020

Mechanisms of inflammasome activation: recent advances and novel insights

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12 December 2020

Interleukin-22 induces interleukin-18 expression from epithelial cells during intestinal infection

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12 December 2020

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.

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12 December 2020

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease

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12 December 2020

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

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12 December 2020

Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3⁺ Treg cell function in the intestine.

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12 December 2020

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome.

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12 December 2020

Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury

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12 December 2020

A Role for Gut Microbiota and the Metabolite-Sensing Receptor GPR43 in a Murine Model of Gout

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12 December 2020

Diverse Activators of the NLRP3 Inflammasome Promote IL-1β Secretion by Triggering Necrosis

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12 December 2020

Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer

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12 December 2020

Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3

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12 December 2020

Cutting Edge: Inflammasome Activation in Primary Human Macrophages Is Dependent on Flagellin

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12 December 2020

mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation.

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12 December 2020

The interleukin (IL)-1 cytokine family--Balance between agonists and antagonists in inflammatory diseases

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12 December 2020

Interleukin-18 genetic polymorphisms contribute differentially to the susceptibility to Crohn's disease

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12 December 2020

Strong Upregulation of AIM2 and IFI16 Inflammasomes in the Mucosa of Patients with Active Inflammatory Bowel Disease.

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12 December 2020

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

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12 December 2020

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.

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12 December 2020

Nlrp6 regulates intestinal antiviral innate immunity

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12 December 2020

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

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12 December 2020

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

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12 December 2020

Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling.

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12 December 2020

Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis

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12 December 2020

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

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12 December 2020

The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense.

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12 December 2020

Mucosal Barrier Depletion and Loss of Bacterial Diversity are Primary Abnormalities in Paediatric Ulcerative Colitis

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12 December 2020

Interleukin-1 antagonism moderates the inflammatory state associated with Type 1 diabetes during clinical trials conducted at disease onset

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12 December 2020

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

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12 December 2020

Human Monocytes Engage an Alternative Inflammasome Pathway

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12 December 2020

NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo.

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12 December 2020

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

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12 December 2020

Genetic functions of the NAIP family of inflammasome receptors for bacterial ligands in mice

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12 December 2020

Inflammasome Complexes: Emerging Mechanisms and Effector Functions

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12 December 2020

Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation

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12 December 2020

RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury

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12 December 2020

Pore-forming activity and structural autoinhibition of the gasdermin family

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12 December 2020

A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion

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12 December 2020

Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan

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12 December 2020

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

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12 December 2020

Border Security: The Role of RIPK3 in Epithelium Homeostasis

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12 December 2020

NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages

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12 December 2020

AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity

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12 December 2020

MLKL and FADD Are Critical for Suppressing Progressive Lymphoproliferative Disease and Activating the NLRP3 Inflammasome.

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12 December 2020

The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway

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12 December 2020

Arterial Effects of Canakinumab in Patients With Atherosclerosis and Type 2 Diabetes or Glucose Intolerance.

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12 December 2020

Roles for Intestinal Bacteria, Viruses, and Fungi in Pathogenesis of Inflammatory Bowel Diseases and Therapeutic Approaches

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12 December 2020

PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

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12 December 2020

Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs.

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12 December 2020

The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury.

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12 December 2020

The Pathogenic Role of NLRP3 Inflammasome Activation in Inflammatory Bowel Diseases of Both Mice and Humans.

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12 December 2020

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner.

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12 December 2020

MLKL Activation Triggers NLRP3-Mediated Processing and Release of IL-1β Independently of Gasdermin-D.

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12 December 2020

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.

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12 December 2020

Distinct Kinase-Independent Role of RIPK3 in CD11c+ Mononuclear Phagocytes in Cytokine-Induced Tissue Repair

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12 December 2020

Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation.

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12 December 2020

NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8.

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12 December 2020

P2X1, P2X4, and P2X7 Receptor Knock Out Mice Expose Differential Outcome of Sepsis Induced by α-Haemolysin Producing Escherichia coli

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12 December 2020

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin.

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12 December 2020

Activation of NLRP3 Inflammasome in Inflammatory Bowel Disease: Differences Between Crohn's Disease and Ulcerative Colitis

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12 December 2020

NLRP6 Protects Il10-/- Mice from Colitis by Limiting Colonization of Akkermansia muciniphila

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12 December 2020

Gasdermins: Effectors of Pyroptosis

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12 December 2020

Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells

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12 December 2020

Inflammasomes on the Crossroads of Innate Immune Recognition and Metabolic Control

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12 December 2020

Nlrp6- and ASC-Dependent Inflammasomes Do Not Shape the Commensal Gut Microbiota Composition

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12 December 2020

The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion.

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12 December 2020

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages.

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12 December 2020

Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis

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12 December 2020

The NLR Protein NLRP6 Does Not Impact Gut Microbiota Composition

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12 December 2020

Shaping of Intestinal Microbiota in Nlrp6- and Rag2-Deficient Mice Depends on Community Structure.

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12 December 2020

10.1016/J.MOLMED.2018.01.004

Identifiers

DOI

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30 June 2019

PMC publication ID

6456255

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30 June 2019

PubMed publication ID

29433944

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30 June 2019