(Q50130565)

22 June 2018

title

mTOR pathway activation drives lung cell senescence and emphysema. (English)

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22 June 2018

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17

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22 June 2018

Bernard Maitre

object named as

Bernard Maitre

13

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Genevieve Derumeaux

object named as

Genevieve Derumeaux

18

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Larissa Lipskaia

6

object named as

Larissa Lipskaia

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22 June 2018

Amal Houssaini

1

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22 June 2018

Marielle Breau

2

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22 June 2018

Kanny Kebe

3

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22 June 2018

Shariq Abid

4

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22 June 2018

Elisabeth Marcos

5

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22 June 2018

Dominique Rideau

7

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22 June 2018

Aurelien Parpaleix

8

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22 June 2018

Jin Huang

9

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22 June 2018

Valerie Amsellem

10

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22 June 2018

Nora Vienney

11

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22 June 2018

Pierre Validire

12

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22 June 2018

Aya Attwe

14

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22 June 2018

Christina Lukas

15

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22 June 2018

David Vindrieux

16

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22 June 2018

Mario Pende

19

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22 June 2018

Silke Meiners

21

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22 June 2018

Serge Adnot

22

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22 June 2018

publication date

8 February 2018

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22 June 2018

published in

JCI insight

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22 June 2018

volume

3

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22 June 2018

issue

3

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22 June 2018

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5821218/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Emerging role of mTOR in the response to cancer therapeutics

24 June 2018

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Reversal of phenotypes of cellular senescence by pan-mTOR inhibition.

24 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program

24 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

Restoration of Corticosteroid Sensitivity in Chronic Obstructive Pulmonary Disease by Inhibition of Mammalian Target of Rapamycin

24 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

A review of recent developments and applications of morphometry/stereology in lung research

24 June 2018

1 reference

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MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

24 June 2018

1 reference

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Telomere Dysfunction and Cell Senescence in Chronic Lung Diseases: Therapeutic Potential

24 June 2018

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Telomerase mutations in smokers with severe emphysema.

24 June 2018

1 reference

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Role for telomerase in pulmonary hypertension

24 June 2018

1 reference

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Cellular senescence: from physiology to pathology

24 June 2018

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Repression of PLA2R1 by c-MYC and HIF-2alpha promotes cancer growth

24 June 2018

1 reference

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Autophagy regulation by nutrient signaling

24 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

Mammalian target of rapamycin complex 2 (mTORC2) coordinates pulmonary artery smooth muscle cell metabolism, proliferation, and survival in pulmonary arterial hypertension

24 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

Smoking exposure induces human lung endothelial cell adaptation to apoptotic stress

24 June 2018

1 reference

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Nutrient signaling to mTOR and cell growth

24 June 2018

1 reference

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Rapalogs and mTOR inhibitors as anti-aging therapeutics

24 June 2018

1 reference

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24 June 2018

The telomere syndromes

1 reference

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mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis.

24 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice

24 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

mTOR signaling in growth control and disease

24 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

mTOR signaling in disease

24 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy.

24 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

Lifetime risk of developing chronic obstructive pulmonary disease: a longitudinal population study

24 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

Pulmonary artery smooth muscle cell senescence is a pathogenic mechanism for pulmonary hypertension in chronic lung disease

24 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

Effects of HIV protease inhibitors on progression of monocrotaline- and hypoxia-induced pulmonary hypertension in rats

24 June 2018

1 reference

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Chronic obstructive pulmonary disease phenotypes: the future of COPD.

24 June 2018

1 reference

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Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema

24 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

Inflammatory networks during cellular senescence: causes and consequences

24 June 2018

1 reference

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Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

24 June 2018

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Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony

24 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease.

24 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

The senescence-associated secretory phenotype: the dark side of tumor suppression

24 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

24 June 2018

1 reference

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Shortened telomeres in circulating leukocytes of patients with chronic obstructive pulmonary disease

24 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis

24 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

Chemokine signaling via the CXCR2 receptor reinforces senescence

24 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

24 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

TOR signaling in growth and metabolism

24 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper

24 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

24 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

Early restriction of peripheral and proximal cell lineages during formation of the lung

24 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

Cell senescence and cancer

24 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

MUC1 is a novel marker for the type II pneumocyte lineage during lung carcinogenesis

24 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

mTOR Signaling in Growth, Metabolism, and Disease.

24 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

Selective Tuberous Sclerosis Complex 1 Gene Deletion in Smooth Muscle Activates Mammalian Target of Rapamycin Signaling and Induces Pulmonary Hypertension.

14 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

P21-dependent protective effects of a carbon monoxide-releasing molecule-3 in pulmonary hypertension

14 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

Clusters of comorbidities based on validated objective measurements and systemic inflammation in patients with chronic obstructive pulmonary disease.

14 August 2018

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The cyclooxygenase-2-prostaglandin E2 pathway maintains senescence of chronic obstructive pulmonary disease fibroblasts.

14 August 2018

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Assessment of air space size characteristics by intercept (chord) measurement: an accurate and efficient stereological approach

14 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

Efficient, inducible Cre-recombinase activation in vascular endothelium.

14 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821218

Pulmonary emphysema with special reference to vascular changes

14 August 2018

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12 December 2020

Cigarette smoke induces senescence in alveolar epithelial cells

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12 December 2020

Alveolar cell senescence in patients with pulmonary emphysema

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12 December 2020

Telomere dysfunction causes sustained inflammation in chronic obstructive pulmonary disease

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12 December 2020

Inducible NOS Inhibition Reverses Tobacco-Smoke-Induced Emphysema and Pulmonary Hypertension in Mice

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12 December 2020

10.1172/JCI.INSIGHT.93203

Identifiers

DOI

1 reference

22 June 2018

PMCID

5821218

1 reference

22 June 2018

PubMed ID

29415880

1 reference

22 June 2018