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Nutrient signaling to mTOR and cell growth
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
23465396
retrieved
1 August 2017
title
Nutrient signaling to mTOR and cell growth
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
23465396
retrieved
1 August 2017
author name string
Jenna L Jewell
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
23465396
retrieved
1 August 2017
Kun-Liang Guan
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
23465396
retrieved
1 August 2017
publication date
1 March 2013
1 reference
stated in
Europe PubMed Central
PubMed ID
23465396
retrieved
1 August 2017
number of pages
10
1 reference
based on heuristic
inferred from page(s)
published in
Trends in Biochemical Sciences
1 reference
stated in
Europe PubMed Central
PubMed ID
23465396
retrieved
1 August 2017
volume
38
1 reference
stated in
Europe PubMed Central
PubMed ID
23465396
retrieved
1 August 2017
page(s)
233-242
1 reference
stated in
Europe PubMed Central
PubMed ID
23465396
retrieved
1 August 2017
issue
5
1 reference
stated in
Europe PubMed Central
PubMed ID
23465396
retrieved
1 August 2017
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TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1
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Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes
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Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
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Mechanism of proton/substrate coupling in the heptahelical lysosomal transporter cystinosin.
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mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase
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Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway
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mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR
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DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy
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6 July 2018
mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR
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6 July 2018
p62 is a key regulator of nutrient sensing in the mTORC1 pathway.
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6 July 2018
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
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6 July 2018
Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation
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mTOR complex 2 signaling and functions
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Amino acid signaling in TOR activation
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6 July 2018
Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase
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6 July 2018
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
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mTOR: from growth signal integration to cancer, diabetes and ageing
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6 July 2018
CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability
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6 July 2018
Structural conservation of components in the amino acid sensing branch of the TOR pathway in yeast and mammals
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6 July 2018
Termination of autophagy and reformation of lysosomes regulated by mTOR
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6 July 2018
Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation
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6 July 2018
Regulation of mTORC1 by the Rab and Arf GTPases
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6 July 2018
Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly
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6 July 2018
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
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6 July 2018
PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR.
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6 July 2018
The Vam6 GEF controls TORC1 by activating the EGO complex
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6 July 2018
Molecular mechanisms of mTOR-mediated translational control
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6 July 2018
ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy
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6 July 2018
ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery
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6 July 2018
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy
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6 July 2018
Bidirectional transport of amino acids regulates mTOR and autophagy
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6 July 2018
The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes.
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6 July 2018
RalA functions as an indispensable signal mediator for the nutrient-sensing system
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6 July 2018
mTOR signaling: PLD takes center stage
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6 July 2018
Amino acid regulation of TOR complex 1.
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PubMed Central
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6 July 2018
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
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PubMed Central
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6 July 2018
Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34.
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PubMed Central
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6 July 2018
AMPK phosphorylation of raptor mediates a metabolic checkpoint
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6 July 2018
Tel2 regulates the stability of PI3K-related protein kinases
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6 July 2018
GEFs and GAPs: critical elements in the control of small G proteins
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6 July 2018
A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling
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6 July 2018
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth
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6 July 2018
Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin.
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6 July 2018
Localization of Rheb to the endomembrane is critical for its signaling function
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6 July 2018
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
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6 July 2018
TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase.
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6 July 2018
Nutritional control of gene expression: how mammalian cells respond to amino acid limitation
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6 July 2018
The TOR and EGO protein complexes orchestrate microautophagy in yeast
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6 July 2018
Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency
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6 July 2018
Rheb binds and regulates the mTOR kinase
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PubMed Central
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6 July 2018
The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila
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6 July 2018
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
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6 July 2018
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
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6 July 2018
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
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6 July 2018
Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes
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6 July 2018
The structure of the MAPK scaffold, MP1, bound to its partner, p14. A complex with a critical role in endosomal map kinase signaling
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6 July 2018
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
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6 July 2018
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
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PubMed Central
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6 July 2018
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
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PubMed Central
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6 July 2018
Rheb promotes cell growth as a component of the insulin/TOR signalling network
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PubMed Central
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6 July 2018
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
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6 July 2018
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
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6 July 2018
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
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6 July 2018
The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634910
retrieved
6 July 2018
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634910
retrieved
6 July 2018
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634910
retrieved
6 July 2018
Identification and characterization of a lysosomal transporter for small neutral amino acids
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634910
retrieved
6 July 2018
Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634910
retrieved
6 July 2018
The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634910
retrieved
6 July 2018
Amino acid availability regulates p70 S6 kinase and multiple translation factors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634910
retrieved
6 July 2018
Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634910
retrieved
6 July 2018
Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634910
retrieved
6 July 2018
A mammalian protein targeted by G1-arresting rapamycin-receptor complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634910
retrieved
6 July 2018
Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634910
retrieved
6 July 2018
RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634910
retrieved
6 July 2018
Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634910
retrieved
6 July 2018
Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634910
retrieved
27 October 2018
Glutaminolysis activates Rag-mTORC1 signaling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634910
retrieved
27 October 2018
RAG GTPases in nutrient-mediated TOR signaling pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634910
retrieved
27 October 2018
Substrate specificity of the amino acid transporter PAT1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634910
retrieved
27 October 2018
PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634910
retrieved
27 October 2018
Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634910
retrieved
27 October 2018
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3634910
retrieved
27 October 2018
GADD34 inhibits mammalian target of rapamycin signaling via tuberous sclerosis complex and controls cell survival under bioenergetic stress
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23465396
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.TIBS.2013.01.004
1 reference
stated in
Europe PubMed Central
PubMed ID
23465396
retrieved
1 August 2017
PMCID
3634910
1 reference
stated in
Europe PubMed Central
PubMed ID
23465396
retrieved
1 August 2017
PubMed ID
23465396
1 reference
stated in
Europe PubMed Central
PubMed ID
23465396
retrieved
1 August 2017
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