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mTOR complex 2 signaling and functions
scientific article published on 15 July 2011
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scholarly article
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Europe PubMed Central
PMCID
3322468
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10 August 2017
review article
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Europe PubMed Central
title
mTOR complex 2 signaling and functions
(English)
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stated in
Europe PubMed Central
PMCID
3322468
retrieved
10 August 2017
author
Estela Jacinto
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2
object named as
Estela Jacinto
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Europe PubMed Central
PMCID
3322468
retrieved
10 August 2017
author name string
Won Jun Oh
series ordinal
1
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Europe PubMed Central
PMCID
3322468
retrieved
10 August 2017
language of work or name
English
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publication date
15 July 2011
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Europe PubMed Central
PMCID
3322468
retrieved
10 August 2017
published in
Cell Cycle
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stated in
Europe PubMed Central
PMCID
3322468
retrieved
10 August 2017
volume
10
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Europe PubMed Central
PMCID
3322468
retrieved
10 August 2017
page(s)
2305-2316
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stated in
Europe PubMed Central
PMCID
3322468
retrieved
10 August 2017
issue
14
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stated in
Europe PubMed Central
PMCID
3322468
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10 August 2017
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Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size
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11 July 2018
IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.
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11 July 2018
mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways
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11 July 2018
Regulation of plant growth and metabolism by the TOR kinase
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11 July 2018
Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney
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11 July 2018
Activation of mTORC2 by association with the ribosome
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11 July 2018
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.
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11 July 2018
Targeted inhibition of mTORC1 and mTORC2 by active-site mTOR inhibitors has cytotoxic effects in T-cell acute lymphoblastic leukemia.
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11 July 2018
TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation
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11 July 2018
Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate
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11 July 2018
Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size
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11 July 2018
Genome-wide shRNA screen reveals increased mitochondrial dependence upon mTORC2 addiction
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11 July 2018
mTOR: from growth signal integration to cancer, diabetes and ageing
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11 July 2018
mTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashion
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PubMed Central
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11 July 2018
Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/Akt signaling
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PubMed Central
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11 July 2018
Akt and autophagy cooperate to promote survival of drug-resistant glioma
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11 July 2018
mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide
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PubMed Central
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11 July 2018
Prostaglandin E2 activates and utilizes mTORC2 as a central signaling locus for the regulation of mast cell chemotaxis and mediator release
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PubMed Central
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11 July 2018
mTOR complex component Rictor interacts with PKCzeta and regulates cancer cell metastasis
1 reference
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PubMed Central
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11 July 2018
Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
1 reference
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PubMed Central
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11 July 2018
CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability
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PubMed Central
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11 July 2018
Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction
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PubMed Central
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11 July 2018
Steady-state kinetic and inhibition studies of the mammalian target of rapamycin (mTOR) kinase domain and mTOR complexes
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PubMed Central
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11 July 2018
Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes
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11 July 2018
Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells.
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PubMed Central
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11 July 2018
Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways
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PubMed Central
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11 July 2018
Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells
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11 July 2018
The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway
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11 July 2018
Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null mice
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11 July 2018
Structure of the human mTOR complex I and its implications for rapamycin inhibition.
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11 July 2018
Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2.
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PubMed Central
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11 July 2018
Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly
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PubMed Central
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11 July 2018
Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy
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11 July 2018
mTOR complex-2 activates ENaC by phosphorylating SGK1.
1 reference
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11 July 2018
Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism
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PubMed Central
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11 July 2018
Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue
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PubMed Central
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11 July 2018
The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1.
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11 July 2018
Growth and aging: a common molecular mechanism
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11 July 2018
PKC and the control of localized signal dynamics.
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11 July 2018
Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor
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11 July 2018
AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity
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11 July 2018
mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action
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11 July 2018
Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy
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11 July 2018
mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling
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11 July 2018
Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway
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11 July 2018
Rictor is a novel target of p70 S6 kinase-1.
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11 July 2018
Protein kinase C: poised to signal
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PubMed Central
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11 July 2018
Targeting mTOR globally in cancer: thinking beyond rapamycin
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11 July 2018
Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1
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PubMed Central
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11 July 2018
Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors
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11 July 2018
Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin
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11 July 2018
The mTORC2 complex regulates terminal differentiation of C2C12 myoblasts
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PubMed Central
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11 July 2018
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
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11 July 2018
mTOR complex 2 in adipose tissue negatively controls whole-body growth
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PubMed Central
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11 July 2018
Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth.
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11 July 2018
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
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11 July 2018
Hypercholesterolemia is associated with hyperactive cardiac mTORC1 and mTORC2 signaling
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PubMed Central
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11 July 2018
Molecular mechanisms of mTOR-mediated translational control
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11 July 2018
mTOR and the control of whole body metabolism
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11 July 2018
Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans
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PubMed Central
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11 July 2018
Regulation of translation initiation in eukaryotes: mechanisms and biological targets
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11 July 2018
mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice
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11 July 2018
Mammalian target of rapamycin complex 1: signalling inputs, substrates and feedback mechanisms.
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11 July 2018
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
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11 July 2018
Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin
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PubMed Central
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11 July 2018
The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail
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PubMed Central
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11 July 2018
Regulation of a third conserved phosphorylation site in SGK1
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PubMed Central
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11 July 2018
The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
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11 July 2018
Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy
1 reference
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PubMed Central
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11 July 2018
Akt/GSK3 signaling in the action of psychotropic drugs
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PubMed Central
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11 July 2018
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
1 reference
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PubMed Central
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11 July 2018
Syndecan-4 regulates subcellular localization of mTOR Complex2 and Akt activation in a PKCalpha-dependent manner in endothelial cells
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PubMed Central
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11 July 2018
p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling
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11 July 2018
A link between SIN1 (MAPKAP1) and poly(rC) binding protein 2 (PCBP2) in counteracting environmental stress
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Hsp70 associates with Rictor and is required for mTORC2 formation and activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
The TSC1-TSC2 complex is required for proper activation of mTOR complex 2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Tel2 regulates the stability of PI3K-related protein kinases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Rapamycin regulates the phosphorylation of rictor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Identification of Protor as a novel Rictor-binding component of mTOR complex-2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Endoplasmic reticulum and Golgi localization sequences for mammalian target of rapamycin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Sin1 binds to both ATF-2 and p38 and enhances ATF-2-dependent transcription in an SAPK signaling pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
(Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Drosophila target of rapamycin kinase functions as a multimer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Molecular organization of target of rapamycin complex 2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Mip1, an MEKK2-interacting protein, controls MEKK2 dimerization and activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
The human stress-activated protein kinase-interacting 1 gene encodes JNK-binding proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Phosphatidic acid-mediated mitogenic activation of mTOR signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
TOR2 is required for organization of the actin cytoskeleton in yeast
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
A mammalian protein targeted by G1-arresting rapamycin-receptor complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
11 July 2018
ER stress inhibits mTORC2 and Akt signaling through GSK-3β-mediated phosphorylation of rictor.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
24 September 2018
Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
24 September 2018
TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
24 September 2018
In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
24 September 2018
Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
24 September 2018
PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
24 September 2018
Nutrient-dependent multimerization of the mammalian target of rapamycin through the N-terminal HEAT repeat region.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
24 September 2018
mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
24 September 2018
PRR5 encodes a conserved proline-rich protein predominant in kidney: analysis of genomic organization, expression, and mutation status in breast and colorectal carcinomas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
24 September 2018
FKBP12-Rapamycin-associated Protein or Mammalian Target of Rapamycin (FRAP/mTOR) Localization in the Endoplasmic Reticulum and the Golgi Apparatus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322468
retrieved
24 September 2018
FKBP12-Rapamycin-associated Protein (FRAP) Autophosphorylates at Serine 2481 under Translationally Repressive Conditions
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21670596
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21670596
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A novel N-terminal hydrophobic motif mediates constitutive degradation of serum- and glucocorticoid-induced kinase-1 by the ubiquitin-proteasome pathway
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21670596
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.4161/CC.10.14.16586
1 reference
stated in
Europe PubMed Central
PMCID
3322468
retrieved
10 August 2017
PMCID
3322468
1 reference
stated in
Europe PubMed Central
PMCID
3322468
retrieved
10 August 2017
PubMed ID
21670596
1 reference
stated in
Europe PubMed Central
PMCID
3322468
retrieved
10 August 2017
ResearchGate publication ID
51216700
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