(Q34041305)

30 July 2017

title

Cellular senescence: from physiology to pathology (English)

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30 July 2017

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2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24954210%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

author name string

Daniel Muñoz-Espín

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24954210%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

publication date

1 July 2014

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Nature Reviews Molecular Cell Biology

30 July 2017

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24954210%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

volume

15

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24954210%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

issue

7

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24954210%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

page(s)

482-496

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24954210%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrm3823

9 June 2020

exact match

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cites work

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Cellular senescence: when bad things happen to good cells

31 March 2020

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31 March 2020

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Senescence in tumours: evidence from mice and humans

31 March 2020

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Oncogene-induced senescence: the bright and dark side of the response

31 March 2020

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The role of senescent cells in ageing

31 March 2020

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The essence of senescence

31 March 2020

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Cellular senescence and its effector programs

31 March 2020

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Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence

31 March 2020

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Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

31 March 2020

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Telomeres shorten during ageing of human fibroblasts

31 March 2020

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Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

31 March 2020

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Feedback between p21 and reactive oxygen production is necessary for cell senescence

31 March 2020

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Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

31 March 2020

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The regulation of INK4/ARF in cancer and aging

31 March 2020

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Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.

31 March 2020

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Ink4a/Arf expression is a biomarker of aging

31 March 2020

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The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

31 March 2020

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The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

31 March 2020

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Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer

31 March 2020

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The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis

31 March 2020

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Cellular senescence: unravelling complexity

31 March 2020

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p38(MAPK) in the senescence of human and murine fibroblasts.

31 March 2020

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Oxidative DNA damage and senescence of human diploid fibroblast cells.

31 March 2020

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Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species

31 March 2020

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Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence

31 March 2020

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PRAK is essential for ras-induced senescence and tumor suppression

31 March 2020

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

31 March 2020

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A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

31 March 2020

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A negative feedback signaling network underlies oncogene-induced senescence

31 March 2020

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VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.

31 March 2020

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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

31 March 2020

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

31 March 2020

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p53: guardian of the genome and policeman of the oncogenes.

31 March 2020

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An oncogene-induced DNA damage model for cancer development

31 March 2020

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Cellular senescence: hot or what?

31 March 2020

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Aging, cellular senescence, and cancer

31 March 2020

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The senescence-associated secretory phenotype: the dark side of tumor suppression

31 March 2020

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Senescence-messaging secretome: SMS-ing cellular stress

31 March 2020

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Chemokine signaling via the CXCR2 receptor reinforces senescence

31 March 2020

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Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

31 March 2020

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Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network

31 March 2020

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

31 March 2020

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Immune surveillance of senescent cells--biological significance in cancer- and non-cancer pathologies

31 March 2020

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A complex secretory program orchestrated by the inflammasome controls paracrine senescence

31 March 2020

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A senescent cell bystander effect: senescence-induced senescence

31 March 2020

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IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine 'bystander senescence'.

31 March 2020

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Programmed cell senescence during mammalian embryonic development.

31 March 2020

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Senescence is a developmental mechanism that contributes to embryonic growth and patterning

31 March 2020

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The quail mesonephros: a new model for renal senescence?

31 March 2020

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Senescence-associated β-galactosidase activity marks the visceral endoderm of mouse embryos but is not indicative of senescence

31 March 2020

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Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.

31 March 2020

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Programmed cell death in animal development and disease

31 March 2020

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The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

31 March 2020

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BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program

31 March 2020

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A senescence-like cell-cycle arrest occurs during megakaryocytic maturation: implications for physiological and pathological megakaryocytic proliferation

31 March 2020

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Cell fusion induced by ERVWE1 or measles virus causes cellular senescence

31 March 2020

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Developmentally programmed endoreduplication in animals

31 March 2020

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Restoration of p53 function leads to tumour regression in vivo

31 March 2020

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Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts

31 March 2020

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Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer

31 March 2020

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Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma

31 March 2020

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Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma

31 March 2020

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Blockbuster dreams for Pfizer's CDK inhibitor.

31 March 2020

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Phase II trial of the CDK4 inhibitor PD0332991 in patients with advanced CDK4-amplified well-differentiated or dedifferentiated liposarcoma.

31 March 2020

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Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B.

31 March 2020

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Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis

31 March 2020

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Senescence of activated stellate cells limits liver fibrosis

31 March 2020

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The anti-fibrotic effects of CCN1/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated TGF-β signaling.

31 March 2020

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Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts.

31 March 2020

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INK4a knockout mice exhibit increased fibrosis under normal conditions and in response to unilateral ureteral obstruction

31 March 2020

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Role of cellular senescence in hepatic wound healing and carcinogenesis.

31 March 2020

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Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice

31 March 2020

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Atorvastatin inhibits proliferation and apoptosis, but induces senescence in hepatic myofibroblasts and thereby attenuates hepatic fibrosis in rats

31 March 2020

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The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

31 March 2020

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Cellular senescence controls fibrosis in wound healing

31 March 2020

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Senescent mesenchymal cells accumulate in human fibrosis by a telomere-independent mechanism and ameliorate fibrosis through matrix metalloproteinases

31 March 2020

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Telomere shortening and cellular senescence in a model of chronic renal allograft rejection

31 March 2020

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Senescence of renal cells: molecular basis and clinical implications

31 March 2020

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Tubular cell senescence and expression of TGF-beta1 and p21(WAF1/CIP1) in tubulointerstitial fibrosis of aging rats

31 March 2020

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Accelerated senescence of renal tubular epithelial cells is associated with disease progression of patients with immunoglobulin A (IgA) nephropathy.

31 March 2020

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Accelerated senescence in the kidneys of patients with type 2 diabetic nephropathy

31 March 2020

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Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a

31 March 2020

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Increased cellular senescence and vascular rarefaction exacerbate the progression of kidney fibrosis in aged mice following transient ischemic injury

31 March 2020

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CDK4/6 inhibition induces epithelial cell cycle arrest and ameliorates acute kidney injury.

31 March 2020

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Cellular senescence limits regenerative capacity and allograft survival.

31 March 2020

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Senescent cardiac fibroblast is critical for cardiac fibrosis after myocardial infarction

31 March 2020

1 reference

Vascular endothelial senescence: from mechanisms to pathophysiology.

31 March 2020

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The roles of senescence and telomere shortening in cardiovascular disease

31 March 2020

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Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence

31 March 2020

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Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction

31 March 2020

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Expression of Chr9p21 genes CDKN2B (p15(INK4b)), CDKN2A (p16(INK4a), p14(ARF)) and MTAP in human atherosclerotic plaque.

31 March 2020

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Topographical association between the cyclin-dependent kinases inhibitor P21, p53 accumulation, and cellular proliferation in human atherosclerotic tissue

31 March 2020

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p19(ARF) deficiency reduces macrophage and vascular smooth muscle cell apoptosis and aggravates atherosclerosis

31 March 2020

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Endogenous p53 Protects Vascular Smooth Muscle Cells From Apoptosis and Reduces Atherosclerosis in ApoE Knockout Mice

31 March 2020

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The role of p53 in atherosclerosis

31 March 2020

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Enhanced susceptibility of cyclin kinase inhibitor p21 knockout mice to high fat diet induced atherosclerosis

31 March 2020

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The growth suppressor p27(Kip1) protects against diet-induced atherosclerosis

31 March 2020

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Increased p53 gene dosage reduces neointimal thickening induced by mechanical injury but has no effect on native atherosclerosis

31 March 2020

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Endothelial cellular senescence is inhibited by liver X receptor activation with an additional mechanism for its atheroprotection in diabetes

31 March 2020

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How stem cells age and why this makes us grow old.

31 March 2020

1 reference

Review: a meta-analysis of GWAS and age-associated diseases

31 March 2020

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INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis

31 March 2020

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Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice

31 March 2020

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Cdkn2a is an atherosclerosis modifier locus that regulates monocyte/macrophage proliferation.

31 March 2020

1 reference

Pulmonary artery smooth muscle cell senescence is a pathogenic mechanism for pulmonary hypertension in chronic lung disease

31 March 2020

1 reference

p53 Gene deficiency promotes hypoxia-induced pulmonary hypertension and vascular remodeling in mice

31 March 2020

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Activation of lung p53 by Nutlin-3a prevents and reverses experimental pulmonary hypertension

31 March 2020

1 reference

The ageing haematopoietic stem cell compartment

31 March 2020

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Short telomeres are a risk factor for idiopathic pulmonary fibrosis

31 March 2020

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Telomerase mutations in families with idiopathic pulmonary fibrosis

31 March 2020

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Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema

31 March 2020

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Bleomycin induces cellular senescence in alveolar epithelial cells

31 March 2020

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Senescence-associated secretory phenotype in a mouse model of bleomycin-induced lung injury

31 March 2020

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Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells

31 March 2020

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Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance

31 March 2020

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Caveolin-1 deficiency protects from pulmonary fibrosis by modulating epithelial cell senescence in mice

31 March 2020

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Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents

31 March 2020

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Inflammatory mechanisms in obesity

31 March 2020

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A crucial role for adipose tissue p53 in the regulation of insulin resistance

31 March 2020

1 reference

Fat tissue, aging, and cellular senescence

31 March 2020

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HMGA2 expression in white adipose tissue linking cellular senescence with diabetes.

31 March 2020

1 reference

Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

31 March 2020

1 reference

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

31 March 2020

1 reference

Inflammation in obesity and diabetes: islet dysfunction and therapeutic opportunity.

31 March 2020

1 reference

Pancreatic beta cell senescence contributes to the pathogenesis of type 2 diabetes in high-fat diet-induced diabetic mice

31 March 2020

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Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes

31 March 2020

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Diminished pancreatic beta-cell mass in securin-null mice is caused by beta-cell apoptosis and senescence

31 March 2020

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Cdk2 suppresses cellular senescence induced by the c-myc oncogene.

31 March 2020

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Absence of p53-dependent apoptosis combined with nonhomologous end-joining deficiency leads to a severe diabetic phenotype in mice

31 March 2020

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Too many breaks (brakes): pancreatic β-cell senescence leads to diabetes

31 March 2020

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The emerging genetic architecture of type 2 diabetes

31 March 2020

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p16INK4a induces an age-dependent decline in islet regenerative potential

31 March 2020

1 reference

Increased dosage of Ink4/Arf protects against glucose intolerance and insulin resistance associated with aging.

31 March 2020

1 reference

Geriatric muscle stem cells switch reversible quiescence into senescence.

31 March 2020

1 reference

Rejuvenation of the muscle stem cell population restores strength to injured aged muscles

31 March 2020

1 reference

Aging increases CCN1 expression leading to muscle senescence

31 March 2020

1 reference

p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice

31 March 2020

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mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis.

31 March 2020

1 reference

Changes and function of circulating endothelial progenitor cells in patients with cerebral aneurysm

31 March 2020

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Coronary artery aneurysm induced by Kawasaki disease in children show features typical senescence

31 March 2020

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Genome-wide association study of intracranial aneurysm identifies three new risk loci

31 March 2020

1 reference

Genetics of abdominal aortic aneurysm

31 March 2020

1 reference

Cellular senescence in the glaucomatous outflow pathway

31 March 2020

1 reference

Genome-wide association study and meta-analysis of intraocular pressure

31 March 2020

1 reference

Chromosome 9p21 primary open-angle glaucoma susceptibility locus: a review.

31 March 2020

1 reference

Astrocyte senescence as a component of Alzheimer's disease

31 March 2020

1 reference

Environmental stress, ageing and glial cell senescence: a novel mechanistic link to Parkinson's disease?

31 March 2020

1 reference

Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease

31 March 2020

1 reference

Linkage and association study of late-onset Alzheimer disease families linked to 9p21.3.

31 March 2020

1 reference

Increased expression of senescence markers in cystic fibrosis airways

31 March 2020

1 reference

Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel disease

31 March 2020

1 reference

Chondrocyte senescence, joint loading and osteoarthritis

31 March 2020

1 reference

The role of chondrocyte senescence in osteoarthritis

31 March 2020

1 reference

Senescence in human intervertebral discs

31 March 2020

1 reference

Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration

31 March 2020

1 reference

BMP4 mediates oxidative stress-induced retinal pigment epithelial cell senescence and is overexpressed in age-related macular degeneration

31 March 2020

1 reference

Fibrotic response of tissue remodeling in COPD.

31 March 2020

1 reference

Cigarette smoke induces senescence in alveolar epithelial cells

31 March 2020

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Alveolar cell senescence exacerbates pulmonary inflammation in patients with chronic obstructive pulmonary disease

31 March 2020

1 reference

Senescence determines the fate of activated rat pancreatic stellate cells.

31 March 2020

1 reference

BRAFE600-associated senescence-like cell cycle arrest of human naevi

31 March 2020

1 reference

Pro-senescence therapy for cancer treatment

31 March 2020

1 reference

The power and the promise of oncogene-induced senescence markers.

31 March 2020

1 reference

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

31 March 2020

1 reference

Autophagy mediates the mitotic senescence transition

31 March 2020

1 reference

Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues

31 March 2020

1 reference

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

31 March 2020

1 reference

Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA

31 March 2020

1 reference

Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer.

31 March 2020

1 reference

Lamin A-dependent nuclear defects in human aging

31 March 2020

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Tumour biology: senescence in premalignant tumours

31 March 2020

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The role of nuclear lamin B1 in cell proliferation and senescence.

31 March 2020

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Lamin B1 loss is a senescence-associated biomarker.

31 March 2020

1 reference

Cellular senescence in aging primates.

31 March 2020

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DNA damage response and cellular senescence in tissues of aging mice

31 March 2020

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31 March 2020

The hallmarks of aging

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Inflammatory networks during cellular senescence: causes and consequences

31 March 2020

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Senescent cells: a novel therapeutic target for aging and age-related diseases

31 March 2020

1 reference

Aging, tumor suppression and cancer: high wire-act!

31 March 2020

1 reference

Cellular senescence induced by CD158d reprograms natural killer cells to promote vascular remodeling

31 March 2020

1 reference

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.

31 March 2020

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Senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells

31 March 2020

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12 December 2020

Senescence-associated beta-galactosidase histochemistry for the primate eye.

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12 December 2020

Beta-galactosidase staining on bone marrow. The osteoclast pitfall

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12 December 2020

Replicative senescence in kidney aging, renal disease, and renal transplantation.

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12 December 2020