(Q37365177)

19 August 2017

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title

Senescence-messaging secretome: SMS-ing cellular stress (English)

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19 August 2017

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2

Daniel S Peeper

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19 August 2017

Thomas Kuilman

1

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19 August 2017

language of work or name

English

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publication date

9 January 2009

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19 August 2017

published in

Nature Reviews Cancer

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19 August 2017

volume

9

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19 August 2017

issue

2

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19 August 2017

page(s)

81-94

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

19 August 2017

cites work

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THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

31 March 2020

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

31 March 2020

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Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

31 March 2020

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Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging

31 March 2020

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Telomere dysfunction and tumour suppression: the senescence connection

31 March 2020

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The signals and pathways activating cellular senescence

31 March 2020

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Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

31 March 2020

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Human melanocyte senescence and melanoma susceptibility genes

31 March 2020

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Cellular senescence in vivo: a barrier to tumorigenesis

31 March 2020

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Oncogene-induced cell senescence--halting on the road to cancer

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Living on a break: cellular senescence as a DNA-damage response

31 March 2020

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The common biology of cancer and ageing

31 March 2020

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Molecular markers of senescence in fibroblast-like cultures

31 March 2020

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Insulin-like growth factor binding protein 3 accumulates to high levels in culture medium of senescent and quiescent human fibroblasts.

31 March 2020

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Overexpression of plasminogen activator inhibitor type-1 in senescent fibroblasts from normal subjects and those with Werner syndrome

31 March 2020

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Cellular senescence: when bad things happen to good cells

31 March 2020

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Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network

31 March 2020

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Chemokine signaling via the CXCR2 receptor reinforces senescence

31 March 2020

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Role of insulin-like growth factor 1 receptor signalling in cancer

31 March 2020

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Endocrine regulation of ageing

31 March 2020

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Cellular actions of the insulin-like growth factor binding proteins

31 March 2020

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Regulation of replicative senescence by insulin-like growth factor-binding protein 3 in human umbilical vein endothelial cells

31 March 2020

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Induction of cellular senescence by insulin-like growth factor binding protein-5 through a p53-dependent mechanism

31 March 2020

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Role of insulin-like growth factor binding protein-3 in human umbilical vein endothelial cell senescence

31 March 2020

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Over-expression of insulin-like growth factor binding protein-related protein-1(IGFBP-rP1/mac25) in the M12 prostate cancer cell line alters tumor growth by a delay in G1 and cyclin A associated apoptosis

31 March 2020

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Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7.

31 March 2020

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High frequency of BRAF mutations in nevi

31 March 2020

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BRAF(E600) in benign and malignant human tumours

31 March 2020

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A negative feedback signaling network underlies oncogene-induced senescence

31 March 2020

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Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway.

31 March 2020

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Cellular senescence in naevi and immortalisation in melanoma: a role for p16?

31 March 2020

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Insulin-like growth factor-I extends in vitro replicative life span of skeletal muscle satellite cells by enhancing G1/S cell cycle progression via the activation of phosphatidylinositol 3'-kinase/Akt signaling pathway

31 March 2020

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Genes for insulin-like growth factors I and II are expressed in senescent rat tissues.

31 March 2020

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A Loss of Insulin-like Growth Factor-2 Imprinting Is Modulated by CCCTC-binding Factor Down-regulation at Senescence in Human Epithelial Cells

31 March 2020

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Paternal and maternal genomes confer opposite effects on proliferation, cell-cycle length, senescence, and tumor formation

31 March 2020

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Mannose 6-phosphate receptors: new twists in the tale

31 March 2020

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Insulin-like growth factor binding protein-5 (IGFBP-5) suppresses the tumourigenesis of head and neck squamous cell carcinoma

31 March 2020

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Reduced expression of insulin-like growth factor binding protein-3 and its promoter hypermethylation in human hepatocellular carcinoma

31 March 2020

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Aberrant promoter methylation of insulin-like growth factor binding protein-3 gene in human cancers.

31 March 2020

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The power and the promise of oncogene-induced senescence markers.

31 March 2020

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Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence

31 March 2020

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Senescence, wound healing and cancer: the PAI-1 connection

31 March 2020

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Evolving role of uPA/uPAR system in human cancers

31 March 2020

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Defects in TGF-beta signaling overcome senescence of mouse keratinocytes expressing v-Ha-ras

31 March 2020

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31 March 2020

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Transforming growth factor-beta requires its target plasminogen activator inhibitor-1 for cytostatic activity

31 March 2020

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Targeted deletion of the TGF-beta 1 gene causes rapid progression to squamous cell carcinoma

31 March 2020

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Tumour biology: senescence in premalignant tumours

31 March 2020

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Subcytotoxic H2O2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts

31 March 2020

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Repeated exposure of human skin fibroblasts to UVB at subcytotoxic level triggers premature senescence through the TGF-beta1 signaling pathway.

31 March 2020

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Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells

31 March 2020

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A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation

31 March 2020

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Oncogene-induced senescence as an initial barrier in lymphoma development

31 March 2020

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Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA

31 March 2020

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Definition of pRB- and p53-dependent and -independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci

31 March 2020

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Homozygous deletion of glycogen synthase kinase 3beta bypasses senescence allowing Ras transformation of primary murine fibroblasts

31 March 2020

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Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation

31 March 2020

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Augmented Wnt signaling in a mammalian model of accelerated aging

31 March 2020

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Wnt signalling and its impact on development and cancer

31 March 2020

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Expression profiling identifies three pathways altered in cellular immortalization: interferon, cell cycle, and cytoskeleton.

31 March 2020

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Defining the transcriptome of accelerated and replicatively senescent keratinocytes reveals links to differentiation, interferon signaling, and Notch related pathways

31 March 2020

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Epigenetic silencing of multiple interferon pathway genes after cellular immortalization.

31 March 2020

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Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1.

31 March 2020

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Interferon regulatory factors IRF5 and IRF7 inhibit growth and induce senescence in immortal Li-Fraumeni fibroblasts

31 March 2020

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Role of IFI 16 in cellular senescence of human fibroblasts

31 March 2020

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Proinflammatory cytokine-induced cellular senescence of biliary epithelial cells is mediated via oxidative stress and activation of ATM pathway: a culture study

31 March 2020

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Interferon-α prevents apoptosis of endothelial cells after short-term exposure but induces replicative senescence after continuous stimulation

31 March 2020

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DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation

31 March 2020

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Interferon-alpha repressed telomerase along with G1-accumulation of Daudi cells.

31 March 2020

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Interferon regulatory factor 3 activates p53-dependent cell growth inhibition.

31 March 2020

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Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

31 March 2020

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Extension of the life-span of human endothelial cells by an interleukin-1 alpha antisense oligomer

31 March 2020

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Heparin/endothelial cell growth supplement regulates matrix gene expression and prolongs life span of vascular smooth muscle cells through modulation of interleukin-1

31 March 2020

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Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis.

31 March 2020

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Interleukin-6 and its receptor in cancer: implications for translational therapeutics

31 March 2020

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Interleukin 6: a fibroblast-derived growth inhibitor of human melanoma cells from early but not advanced stages of tumor progression

31 March 2020

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Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis

31 March 2020

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Differential regulation of plasminogen activator and inhibitor gene transcription by the tumor suppressor p53

31 March 2020

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BRAFE600-associated senescence-like cell cycle arrest of human naevi

31 March 2020

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Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture

31 March 2020

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A single receptor binds both insulin-like growth factor II and mannose-6-phosphate

31 March 2020

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M6P/IGFII-receptor complexes urokinase receptor and plasminogen for activation of transforming growth factor-beta1

31 March 2020

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Mannose 6-phosphate/insulin-like growth factor-II receptor targets the urokinase receptor to lysosomes via a novel binding interaction

31 March 2020

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Interactions of recombinant and platelet transforming growth factor-beta 1 precursor with the insulin-like growth factor II/mannose 6-phosphate receptor

31 March 2020

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Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor

31 March 2020

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TGF-beta-induced apoptosis in endothelial cells mediated by M6P/IGFII-R and mini-plasminogen

31 March 2020

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Making sense of latent TGFbeta activation

31 March 2020

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Interleukin-6 and its receptor: a paradigm for cytokines

31 March 2020

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Soluble mannose 6-phosphate/insulin-like growth factor II (IGF-II) receptor inhibits interleukin-6-type cytokine-dependent proliferation by neutralization of IGF-II.

31 March 2020

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Binding of insulin-like growth factor II (IGF-II) by human cation-independent mannose 6-phosphate receptor/IGF-II receptor expressed in receptor-deficient mouse L cells

31 March 2020

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M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity

31 March 2020

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Cellular growth inhibition by IGFBP-3 and TGF-beta1 requires LRP-1

31 March 2020

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The type V transforming growth factor beta receptor is the putative insulin-like growth factor-binding protein 3 receptor

31 March 2020

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Interactions of high affinity insulin-like growth factor-binding proteins with the type V transforming growth factor-beta receptor in mink lung epithelial cells

31 March 2020

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Identification of insulin receptor substrate proteins as key molecules for the TbetaR-V/LRP-1-mediated growth inhibitory signaling cascade in epithelial and myeloid cells

31 March 2020

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Cellular growth inhibition by TGF-beta1 involves IRS proteins

31 March 2020

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31 March 2020

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Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor

31 March 2020

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alpha-2 Macroglobulin receptor/Ldl receptor-related protein(Lrp)-dependent internalization of the urokinase receptor

31 March 2020

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Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes

31 March 2020

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Growth inhibition by insulin-like growth factor-binding protein-3 in T47D breast cancer cells requires transforming growth factor-beta (TGF-beta ) and the type II TGF-beta receptor

31 March 2020

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Signaling through the Smad pathway by insulin-like growth factor-binding protein-3 in breast cancer cells. Relationship to transforming growth factor-beta 1 signaling.

31 March 2020

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Decreased Expression of the Low-density Lipoprotein Receptor-related Protein-1 (LRP-1) in Rats with Prostate Cancer

31 March 2020

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TGF-beta 1 modulation of IGF-I signaling pathway in rat thyroid epithelial cells

31 March 2020

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Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells

31 March 2020

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Interleukin-6 induces cellular insulin resistance in hepatocytes

31 March 2020

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Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects

31 March 2020

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Interleukin-6 impairs the insulin signaling pathway, promoting production of nitric oxide in human umbilical vein endothelial cells

31 March 2020

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

31 March 2020

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Senescence of activated stellate cells limits liver fibrosis

31 March 2020

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Interleukin-1 and cancer progression: the emerging role of interleukin-1 receptor antagonist as a novel therapeutic agent in cancer treatment

31 March 2020

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The role of interleukin-8 in cancer cells and microenvironment interaction

31 March 2020

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The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis

31 March 2020

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Cancer and aging: a model for the cancer promoting effects of the aging stroma

31 March 2020

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Cellular senescence in aging primates.

31 March 2020

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The blockade of IL-6 signaling in rational drug design

31 March 2020

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Oncogenic ras-induced expression of cytokines: a new target of anti-cancer therapeutics

31 March 2020

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Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging

31 March 2020

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Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas

31 March 2020

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PLEIOTROPY, NATURAL SELECTION, AND THE EVOLUTION OF SENESCENCE

31 March 2020

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31 March 2020

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Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence

31 March 2020

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Short telomeres limit tumor progression in vivo by inducing senescence

31 March 2020

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Delayed ageing through damage protection by the Arf/p53 pathway

31 March 2020

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Influence of age on the production of interleukin-8-like chemokine (GRO/CINC-1) in rat nasal mucosa

31 March 2020

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The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians

31 March 2020

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Influence of Age and Long-term Dietary Restriction on Plasma Insulin-like Growth Factor-1 (IGF-1), IGF-1 Gene Expression, and IGF-1 Binding Proteins

31 March 2020

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Internalization of the urokinase-plasminogen activator inhibitor type-1 complex is mediated by the urokinase receptor

31 March 2020

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12 December 2020

Endogenous interleukin 6 can function as an in vivo growth- stimulatory factor for advanced-stage human melanoma cells.

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12 December 2020

Failure of senescent human fibroblasts to express the insulin-like growth factor-1 gene

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12 December 2020

Latent transforming growth factor-beta from human platelets. A high molecular weight complex containing precursor sequences.

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12 December 2020

Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes

1 reference

12 December 2020

Plasmin degradation of insulin-like growth factor-binding protein-5 (IGFBP-5): regulation by IGFBP-5-(201-218)

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12 December 2020

Identification of mannose 6-phosphate in two asparagine-linked sugar chains of recombinant transforming growth factor-beta 1 precursor.

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12 December 2020

Insulin-like growth factor binding protein-related protein 1 inhibits proliferation of MCF-7 breast cancer cells via a senescence-like mechanism

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12 December 2020

Stimulation by insulin-like growth factors is required for cellular transformation by type beta transforming growth factor

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12 December 2020

Insulin-like growth factor binding protein-5 binds to plasminogen activator inhibitor-I

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12 December 2020

Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization

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12 December 2020

Insulin-like growth factor binding protein 3 mediates retinoic acid- and transforming growth factor beta2-induced growth inhibition in human breast cancer cells.

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12 December 2020

Extracellular matrix induced by TGFbeta impairs insulin signal transduction in 3T3-L1 preadipose cells

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12 December 2020

Low density lipoprotein receptor-related protein: regulation of the plasma membrane proteome

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12 December 2020

Smad3 regulates senescence and malignant conversion in a mouse multistage skin carcinogenesis model

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12 December 2020

Interactions between insulin-like growth factor-I (IGF-I) and the system of plasminogen activators and their inhibitors in the control of IGF-binding protein-3 production and proteolysis in human osteosarcoma cells.

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12 December 2020

Identifiers

DOI

10.1038/NRC2560

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19 August 2017

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