(Q50336720)

5 March 2018

title

The scaffolding adapter Gab2, via Shp-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway. (English)

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5 March 2018

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Min Yu

1

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5 March 2018

Jincai Luo

2

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5 March 2018

Wentian Yang

3

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5 March 2018

Yongping Wang

4

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5 March 2018

Masao Mizuki

5

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5 March 2018

Yuzuru Kanakura

6

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5 March 2018

Peter Besmer

7

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5 March 2018

Benjamin G Neel

8

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5 March 2018

Haihua Gu

9

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5 March 2018

language of work or name

English

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publication date

27 July 2006

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5 March 2018

Journal of Biological Chemistry

number of pages

12

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based on heuristic

inferred from page(s)

published in

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5 March 2018

volume

281

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5 March 2018

issue

39

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5 March 2018

page(s)

28615-28626

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5 March 2018

cites work

Mast cells and basophils

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

The biology of stem cell factor and its receptor C-kit

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M603742200

Signal transduction via the stem cell factor receptor/c-Kit

21 January 2018

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Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Normal and oncogenic forms of the receptor tyrosine kinase kit.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M603742200

Critical role for Kit-mediated Src kinase but not PI 3-kinase signaling in pro T and pro B cell development

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M603742200

The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Point mutation in kit receptor tyrosine kinase reveals essential roles for kit signaling in spermatogenesis and oogenesis without affecting other kit responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3'-kinase is essential for male fertility

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Critical roles of c-Kit tyrosine residues 567 and 719 in stem cell factor-induced chemotaxis: contribution of src family kinase and PI3-kinase on calcium mobilization and cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

c-Kit-mediated overlapping and unique functional and biochemical outcomes via diverse signaling pathways.

21 January 2018

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Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Phosphoinositide 3-kinase-dependent activation of Rac.

21 January 2018

1 reference

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The "Gab" in signal transduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Scaffolding protein Gab2 mediates differentiation signaling downstream of Fms receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Participation of both Gab1 and Gab2 in the activation of the ERK/MAPK pathway by epidermal growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

A role for the scaffolding adapter GAB2 in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

A novel role for Gab2 in bFGF-mediated cell survival during retinoic acid-induced neuronal differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Essential role for Gab2 in the allergic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Requirement of Gab2 for mast cell development and KitL/c-Kit signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Plat-E: an efficient and stable system for transient packaging of retroviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Phosphorylation of protein-tyrosine phosphatase PTP-1B on identical sites suggests activation of a common signaling pathway during mitosis and stress response in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Gab1 and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Signaling interplay in Ras superfamily function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Role of the docking protein Gab2 in beta(1)-integrin signaling pathway-mediated hematopoietic cell adhesion and migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Intestinal mast cell progenitors require CD49dbeta7 (alpha4beta7 integrin) for tissue-specific homing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Rho and Rac take center stage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

Identification of mast cell progenitors in adult mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603742200

21 January 2018

Identifiers

DOI

10.1074/JBC.M603742200

1 reference

5 March 2018

1 reference

5 March 2018