(Q50707361)

17 March 2018

title

Understanding the relative roles of pharmacogenetics and ontogeny in pediatric drug development and regulatory science. (English)

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17 March 2018

2

Gregory L Kearns

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17 March 2018

author name string

J Steven Leeder

series ordinal

1

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17 March 2018

Stephen P Spielberg

series ordinal

3

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17 March 2018

John van den Anker

series ordinal

4

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17 March 2018

publication date

11 February 2010

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17 March 2018

The Journal of Clinical Pharmacology

published in

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17 March 2018

volume

50

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17 March 2018

issue

12

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17 March 2018

page(s)

1377-1387

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17 March 2018

Testing medications in children.

cites work

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Pediatric drug labeling: improving the safety and efficacy of pediatric therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Improving pediatric dosing through pediatric initiatives: what we have learned

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

The challenges of delivering pharmacogenomics into clinical pediatrics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Developmental and pediatric pharmacogenomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Pharmacogenetics and pharmacogenomics: development, science, and translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

The ontogeny of drug metabolism enzymes and implications for adverse drug events

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Cough and cold medication use by US children, 1999-2006: results from the slone survey

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Unexpected infant deaths associated with use of cough and cold medications

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Over-the-counter (OTC) medications for acute cough in children and adults in ambulatory settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

The role of CYP2D6 in primary and secondary oxidative metabolism of dextromethorphan: in vitro studies using human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Metabolism of dextromethorphan in vitro: involvement of cytochromes P450 2D6 and 3A3/4, with a possible role of 2E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

The influence of CYP2D6 polymorphism and quinidine on the disposition and antitussive effect of dextromethorphan in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Pharmacokinetics of dextromethorphan after single or multiple dosing in combination with quinidine in extensive and poor metabolizers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Lack of interaction of the NMDA receptor antagonists dextromethorphan and dextrorphan with P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

The roles of CYP2D6 and stereoselectivity in the clinical pharmacokinetics of chlorpheniramine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Identification of human cytochrome p450 isozymes involved in diphenhydramine N-demethylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Elimination of ephedrines in urine following multiple dosing: the consequences for athletes, in relation to doping control

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Impact of CYP2D6*10 on H1-antihistamine-induced hypersomnia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Diphenhydramine alters the disposition of venlafaxine through inhibition of CYP2D6 activity in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Inhibitory effects of H1-antihistamines on CYP2D6- and CYP2C9-mediated drug metabolic reactions in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Significant interaction between the nonprescription antihistamine diphenhydramine and the CYP2D6 substrate metoprolol in healthy men with high or low CYP2D6 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Expression of CYP2D6 in developing human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Developmental changes in human liver CYP2D6 expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Ontogeny of dextromethorphan O- and N-demethylation in the first year of life

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

O-demethylation of tramadol in the first months of life.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Tramadol disposition in the very young: an attempt to assess in vivo cytochrome P-450 2D6 activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Postmenstrual age and CYP2D6 polymorphisms determine tramadol o-demethylation in critically ill neonates and infants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Lower prevalence of the debrisoquin oxidative poor metabolizer phenotype in American black versus white subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Dextromethorphan to dextrorphan urinary metabolic ratio does not reflect dextromethorphan oral clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Extreme discordant phenotype methodology: an intuitive approach to clinical pharmacogenetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Pediatric rheumatology for the adult rheumatologist

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Subtype-specific peripheral blood gene expression profiles in recent-onset juvenile idiopathic arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Impact of the ultrarapid CYP2C19*17 allele on serum concentration of escitalopram in psychiatric patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

Developmental expression of human hepatic CYP2C9 and CYP2C19.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

CYP2D6- and CYP3A-dependent metabolism of dextromethorphan in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009360533

21 January 2018

Identifiers

DOI

10.1177/0091270009360533

1 reference

17 March 2018

1 reference

17 March 2018