(Q50878634)

24 March 2018

title

FK506 reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice. (English)

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24 March 2018

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9

Yoshifumi Iwamaru

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24 March 2018

Ryuichiro Atarashi

13

object named as

Ryuichiro Atarashi

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24 March 2018

author name string

Takehiro Nakagaki

1

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24 March 2018

Katsuya Satoh

2

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24 March 2018

Daisuke Ishibashi

3

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24 March 2018

Takayuki Fuse

4

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24 March 2018

Kazunori Sano

5

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24 March 2018

Yuji O Kamatari

6

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24 March 2018

Kazuo Kuwata

7

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24 March 2018

Kazuto Shigematsu

8

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24 March 2018

Takato Takenouchi

10

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24 March 2018

Hiroshi Kitani

11

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24 March 2018

Noriyuki Nishida

12

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24 March 2018

publication date

19 June 2013

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24 March 2018

published in

Autophagy

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24 March 2018

volume

9

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24 March 2018

issue

9

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24 March 2018

page(s)

1386-1394

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24 March 2018

https://api.crossref.org/works/10.4161%2FAUTO.25381

1 reference

Mammalian prion biology: one century of evolving concepts

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1 reference

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Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation

21 January 2018

1 reference

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Prion diseases--close to effective therapy?

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

Manganese chelation therapy extends survival in a mouse model of M1000 prion disease

21 January 2018

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https://api.crossref.org/works/10.4161%2FAUTO.25381

Continuous intraventricular infusion of pentosan polysulfate: clinical trial against prion diseases.

21 January 2018

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Safety and efficacy of quinacrine in human prion disease (PRION-1 study): a patient-preference trial

21 January 2018

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Therapeutic trials in human transmissible spongiform encephalo-pathies: recent advances and problems to address

21 January 2018

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Therapeutic interventions ameliorating prion disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

Autophagy fights disease through cellular self-digestion

21 January 2018

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https://api.crossref.org/works/10.4161%2FAUTO.25381

Autophagy deregulation in neurodegenerative diseases - recent advances and future perspectives

21 January 2018

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Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

21 January 2018

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Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy

21 January 2018

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https://api.crossref.org/works/10.4161%2FAUTO.25381

Autophagy induction by trehalose counteracts cellular prion infection

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy

21 January 2018

1 reference

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Rapamycin delays disease onset and prevents PrP plaque deposition in a mouse model of Gerstmann-Sträussler-Scheinker disease

21 January 2018

1 reference

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Fighting neurodegeneration with rapamycin: mechanistic insights

21 January 2018

1 reference

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Molecular mechanisms of neuroprotective action of immunosuppressants--facts and hypotheses.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

FK506 protects against various immune responses and secondary degeneration following cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

Inhibition of FK506 binding proteins reduces alpha-synuclein aggregation and Parkinson's disease-like pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

Calcineurin inhibition at the clinical phase of prion disease reduces neurodegeneration, improves behavioral alterations and increases animal survival

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

Reliable determination of binding affinity and kinetics using surface plasmon resonance biosensors.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

Hot spots in prion protein for pathogenic conversion

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

Autophagosome formation and molecular mechanism of autophagy.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

Microglia-specific localisation of a novel calcium binding protein, Iba1

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

Wild-type PrP and a mutant associated with prion disease are subject to retrograde transport and proteasome degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

Proteasomes and ubiquitin are involved in the turnover of the wild-type prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

Disease-associated prion protein oligomers inhibit the 26S proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

Pathogenesis of prion diseases: current status and future outlook

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

Neurotoxicity of a prion protein fragment.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

Role of microglia in central nervous system infections

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

A versatile prion replication assay in organotypic brain slices

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

Molecular basis of anti-apoptotic effect of immunophilin ligands on hydrogen peroxide-induced apoptosis in human glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

Successful transmission of three mouse-adapted scrapie strains to murine neuroblastoma cell lines overexpressing wild-type mouse prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

Microglial cell line established from prion protein-overexpressing mice is susceptible to various murine prion strains

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

Protective role of interferon regulatory factor 3-mediated signaling against prion infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

Monoclonal antibodies inhibit prion replication and delay the development of prion disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25381

21 January 2018

Identifiers

DOI

10.4161/AUTO.25381

1 reference

24 March 2018

PubMed ID

23800841

1 reference

24 March 2018