(Q50944162)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28615452%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

review article

1 reference

title

Interplay of the iron-regulated metastasis suppressor NDRG1 with epidermal growth factor receptor (EGFR) and oncogenic signaling (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28615452%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28615452%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Des R. Richardson

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28615452%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

author name string

Sharleen V Menezes

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28615452%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Zaklina Kovacevic

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28615452%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

language of work or name

English

0 references

publication date

14 June 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28615452%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

22 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28615452%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

volume

292

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28615452%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

issue

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28615452%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

page(s)

12772-12782

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28615452%20AND%20SRC:MED&resulttype=core&format=json

Breast cancer metastasis: markers and models

22 March 2020

cites work

1 reference

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Metals and metastasis: Exploiting the role of metals in cancer metastasis to develop novel anti-metastatic agents.

21 January 2018

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NDRG1, a growth and cancer related gene: regulation of gene expression and function in normal and disease states

21 January 2018

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The metastasis suppressor, Ndrg-1: a new ally in the fight against cancer

21 January 2018

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Cap43/NDRG1/Drg-1 is a molecular target for angiogenesis and a prognostic indicator in cervical adenocarcinoma.

21 January 2018

1 reference

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NDRG1 overexpression promotes the progression of esophageal squamous cell carcinoma through modulating Wnt signaling pathway

21 January 2018

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The iron-regulated metastasis suppressor, Ndrg-1: identification of novel molecular targets

21 January 2018

1 reference

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The metastasis suppressor, N-myc downstream regulated gene 1 (NDRG1), upregulates p21 via p53-independent mechanisms.

21 January 2018

1 reference

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EGFR signaling promotes TGFβ-dependent renal fibrosis

21 January 2018

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Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors.

21 January 2018

1 reference

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The iron-regulated metastasis suppressor NDRG1 targets NEDD4L, PTEN, and SMAD4 and inhibits the PI3K and Ras signaling pathways

21 January 2018

1 reference

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The metastasis suppressor NDRG1 modulates the phosphorylation and nuclear translocation of β-catenin through mechanisms involving FRAT1 and PAK4.

21 January 2018

1 reference

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The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1.

21 January 2018

1 reference

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Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling.

21 January 2018

1 reference

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The Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling Pathways

21 January 2018

1 reference

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N-myc downstream regulated gene 1 modulates Wnt-β-catenin signalling and pleiotropically suppresses metastasis

21 January 2018

1 reference

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N-myc downstream regulated gene 1/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of inhibitor of kappaB kinase beta expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Iron chelators with high antiproliferative activity up-regulate the expression of a growth inhibitory and metastasis suppressor gene: a link between iron metabolism and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

N-myc downstream regulated 1 (NDRG1) is regulated by eukaryotic initiation factor 3a (eIF3a) during cellular stress caused by iron depletion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

The iron chelators Dp44mT and DFO inhibit TGF-β-induced epithelial-mesenchymal transition via up-regulation of N-Myc downstream-regulated gene 1 (NDRG1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Targeting the metastasis suppressor, NDRG1, using novel iron chelators: regulation of stress fiber-mediated tumor cell migration via modulation of the ROCK1/pMLC2 signaling pathway

21 January 2018

1 reference

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Dp44mT targets the AKT, TGF-β and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Iron chelator-mediated alterations in gene expression: identification of novel iron-regulated molecules that are molecular targets of hypoxia-inducible factor-1 alpha and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Novel thiosemicarbazone iron chelators induce up-regulation and phosphorylation of the metastasis suppressor N-myc down-stream regulated gene 1: a new strategy for the treatment of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Nitric oxide suppresses tumor cell migration through N-Myc downstream-regulated gene-1 (NDRG1) expression: role of chelatable iron

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Effect of nickel and iron co-exposure on human lung cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Egr-1 mediates hypoxia-inducible transcription of the NDRG1 gene through an overlapping Egr-1/Sp1 binding site in the promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Iron and cancer: more ore to be mined

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Novel di-2-pyridyl-derived iron chelators with marked and selective antitumor activity: in vitro and in vivo assessment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

The evolution of iron chelators for the treatment of iron overload disease and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Src-mediated regulation of E-cadherin and EMT in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

The interplay between Src family kinases and receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Identification of c-Src tyrosine kinase substrates in platelet-derived growth factor receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Functional implication of the interaction between EGF receptor and c-Src

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Using structure to define the function of phosphoinositide 3-kinase family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

The activation of Akt/PKB signaling pathway and cell survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Interleukin-6 activates PI3K/Akt pathway and regulates cyclin A1 to promote prostate cancer cell survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

PTEN Inhibits Cell Proliferation, Promotes Cell Apoptosis, and Induces Cell Cycle Arrest via Downregulating the PI3K/AKT/hTERT Pathway in Lung Adenocarcinoma A549 Cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

PTEN up-regulates the tumor metastasis suppressor gene Drg-1 in prostate and breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Overexpression of N-myc downstream-regulated gene 1 inhibits human glioma proliferation and invasion via phosphoinositide 3-kinase/AKT pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance

21 January 2018

1 reference

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EGF-ERBB signalling: towards the systems level

21 January 2018

1 reference

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The ErbB/HER family of protein-tyrosine kinases and cancer

21 January 2018

1 reference

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Role of ErbB Receptors in Cancer Cell Migration and Invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Quantitative proteomics and phosphoproteomics reveal novel insights into complexity and dynamics of the EGFR signaling network.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

EGFR kinase possesses a broad specificity for ErbB phosphorylation sites, and ligand increases catalytic-centre activity without affecting substrate binding affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Epidermal growth factor receptor: mechanisms of activation and signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Shc Phosphotyrosine-Binding Domain Dominantly Interacts with Epidermal Growth Factor Receptors and Mediates Ras Activation in Intact Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4-NDRG1 Axis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

EGFR regulates iron homeostasis to promote cancer growth through redistribution of transferrin receptor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Pgrmc1 (progesterone receptor membrane component 1) associates with epidermal growth factor receptor and regulates erlotinib sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Role of Pgrmc1 in estrogen maintenance of meiotic arrest in zebrafish oocytes through Gper/Egfr

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

PGRMC1 regulation by phosphorylation: potential new insights in controlling biological activity!

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Regulation of epidermal growth factor receptor down-regulation by UBPY-mediated deubiquitination at endosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Truncation, modification, and optimization of MIG6(segment 2) peptide to target lung cancer-related EGFR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Mitogen-inducible gene 6 (MIG-6), adipophilin and tuftelin are inducible by hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Tyrosine phosphorylation of mig6 reduces its inhibition of the epidermal growth factor receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

SOCS1 induced by NDRG2 expression negatively regulates STAT3 activation in breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

KAI1/CD82, a tumor metastasis suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Requirement of the p130CAS-Crk Coupling for Metastasis Suppressor KAI1/CD82-mediated Inhibition of Cell Migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

KAI1 gene is engaged in NDRG1 gene-mediated metastasis suppression through the ATF3-NFkappaB complex in human prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Attenuation of EGF receptor signaling by a metastasis suppressor, the tetraspanin CD82/KAI-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

The expression of the KAI1 gene, a tumor metastasis suppressor, is directly activated by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Differential targeting of the cyclin-dependent kinase inhibitor, p21CIP1/WAF1, by chelators with anti-proliferative activity in a range of tumor cell-types

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

The novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Future of toxicology--iron chelators and differing modes of action and toxicity: the changing face of iron chelation therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Design, synthesis, and characterization of new iron chelators with anti-proliferative activity: structure-activity relationships of novel thiohydrazone analogues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

Antitumor activity of metal-chelating compound Dp44mT is mediated by formation of a redox-active copper complex that accumulates in lysosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R117.776393

LSD1 mediates MYCN control of epithelial-mesenchymal transition through silencing of metastatic suppressor NDRG1 gene.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5546018

The emerging role of progesterone receptor membrane component 1 (PGRMC1) in cancer biology.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5546018

Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5546018

Prognostic impact of NDRG2 and NDRG3 in prostate cancer patients undergoing radical prostatectomy

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5546018

Examination of the antiproliferative activity of iron chelators: multiple cellular targets and the different mechanism of action of triapine compared with desferrioxamine and the potent pyridoxal isonicotinoyl hydrazone analogue 311.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5546018

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5546018

ErbB tyrosine kinases and the two neuregulin families constitute a ligand-receptor network.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5546018

Shc phosphotyrosine-binding domain dominantly interacts with epidermal growth factor receptors and mediates Ras activation in intact cells

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5546018

Direct analysis of the binding of the abl Src homology 2 domain to the activated epidermal growth factor receptor.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5546018

In vitro-targeted gene identification in patients with hepatitis C using a genome-wide microarray technology

2 November 2018

1 reference

12 December 2020

Overexpression of NDRG1 is an indicator of poor prognosis in hepatocellular carcinoma

1 reference

12 December 2020

Dipyridyl Thiosemicarbazone Chelators with Potent and Selective Antitumor Activity Form Iron Complexes with Redox Activity

1 reference

12 December 2020

Role of ribonucleotide reductase in inhibition of mammalian cell growth by potent iron chelators

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.R117.776393

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28615452%20AND%20SRC:MED&resulttype=core&format=json

release_jqxh3aotvrdtlishhyjtpvwvem

22 March 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/jqxh3aotvrdtlishhyjtpvwvem

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28615452%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

PubMed publication ID

28615452

1 reference