(Q51623974)

8 April 2018

title

Cdkn2a suppresses metastasis in squamous cell carcinomas induced by the gain-of-function mutant p53(R172H). (English)

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7

Olivier Lichtarge

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Zhongyou Li

1

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Cassandra L Gonzalez

2

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Bingbing Wang

3

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Yuanyuan Zhang

4

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Olga Mejia

5

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Panagiotis Katsonis

6

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Jeffrey N Myers

8

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Adel K El-Naggar

9

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Carlos Caulin

10

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publication date

22 July 2016

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published in

Journal of Pathology

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volume

240

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issue

2

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page(s)

224-234

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Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1

cites work

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The mutational landscape of head and neck squamous cell carcinoma

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Comprehensive genomic characterization of head and neck squamous cell carcinomas

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Mutational landscape of aggressive cutaneous squamous cell carcinoma

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Genomic analysis of metastatic cutaneous squamous cell carcinoma

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Gain of function mutations in p53.

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Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation.

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Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

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Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis

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Heterogeneity of Li-Fraumeni syndrome links to unequal gain-of-function effects of p53 mutations.

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TP53 mutations and survival in squamous-cell carcinoma of the head and neck.

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Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer.

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An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations

21 January 2018

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Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras.

21 January 2018

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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

21 January 2018

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Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

21 January 2018

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

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Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

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Immunohistochemical comparison of p16 expression in actinic keratoses and squamous cell carcinomas of the skin

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Retinoblastoma protein function and p16INK4a expression in actinic keratosis, squamous cell carcinoma in situ and invasive squamous cell carcinoma of the skin and links between p16INK4a expression and infiltrative behavior

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Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

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Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

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In utero activation of K5.CrePR1 induces gene deletion

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The landscape of viral expression and host gene fusion and adaptation in human cancer

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UV and skin cancer: specific p53 gene mutation in normal skin as a biologically relevant exposure measurement

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Inflammation and Hras signaling control epithelial-mesenchymal transition during skin tumor progression.

21 January 2018

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Chromosomal instability and phenotypic plasticity during the squamous-spindle carcinoma transition: association of a specific T(14;15) with malignant progression

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The Ink4/Arf locus is a barrier for iPS cell reprogramming

21 January 2018

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Spindle cell neoplasms encountered in dermatologic surgery: a review

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Sunburn and p53 in the onset of skin cancer

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/PATH.4770

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8 April 2018

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8 April 2018