(Q41046980)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

title

Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Vlad C. Sandulache

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

17

Gordon B Mills

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

18

Mien-Chie Hung

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

14

Yongkun Wei

1 reference

19 March 2020

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json

Ge Zhou

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Jiping Wang

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Mei Zhao

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Tong-Xin Xie

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Noriaki Tanaka

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Ameeta A Patel

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Alexandra M Ward

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Samar A Jasser

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Heath D Skinner

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Alison Lea Fitzgerald

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Abdullah A Osman

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Xuefeng Xia

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Zhou Songyang

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Carlos Caulin

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Jiyong Liang

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Jeffrey N Myers

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

publication date

22 May 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

volume

54

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

page(s)

960-974

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json

AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity

19 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

Metabolic regulation by p53 family members.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

26 September 2017

p53 mutations in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

TAp63 is a master transcriptional regulator of lipid and glucose metabolism

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

Regulation of lipid metabolism by p53 - fighting two villains with one sword.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

Mutant p53: one name, many proteins

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

Metabolic reprogramming: a cancer hallmark even warburg did not anticipate

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

AMPK: a nutrient and energy sensor that maintains energy homeostasis

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene signature

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

Cellular metabolism and disease: what do metabolic outliers teach us?

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

Disruptive TP53 mutation is associated with aggressive disease characteristics in an orthotopic murine model of oral tongue cancer

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

The mutational landscape of head and neck squamous cell carcinoma

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

A fluorescent reporter of AMPK activity and cellular energy stress

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

Hallmarks of Cancer: The Next Generation

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

mTOR: from growth signal integration to cancer, diabetes and ageing

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

Radiographic thumb osteoarthritis: frequency, patterns and associations with pain and clinical assessment findings in a community-dwelling population

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

AMPK as a metabolic tumor suppressor: control of metabolism and cell growth

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

Mutant p53 gain-of-function in cancer

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

Understanding the Warburg effect: the metabolic requirements of cell proliferation

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

Heterozygosity for hypoxia inducible factor 1alpha decreases the incidence of thymic lymphomas in a p53 mutant mouse model

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

Are interactions with p63 and p73 involved in mutant p53 gain of oncogenic function?

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

Mutant p53 facilitates pro-angiogenic, hyperproliferative phenotype in response to chronic relative hypoxia

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

Regulation of fatty acid synthesis and oxidation by the AMP-activated protein kinase

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

Mutant p53 protein localized in the cytoplasm inhibits autophagy

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

S-adenosylmethionine attenuates hepatic lipid synthesis in micropigs fed ethanol with a folate-deficient diet

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067806

Phosphorylation of rat muscle acetyl-CoA carboxylase by AMP-activated protein kinase and protein kinase A

2 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24857548

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24857548

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Localization of AMP kinase is regulated by stress, cell density, and signaling through the MEK-->ERK1/2 pathway

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24857548

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.MOLCEL.2014.04.024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

PubMed publication ID

24857548

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24857548%20AND%20SRC:MED&resulttype=core&format=json