(Q51765249)

11 April 2018

title

Arachidonic acid metabolism via cytosolic phospholipase A2 α induces cytotoxicity in niemann-pick disease type C cells. (English)

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Niemann-Pick disease, type C1

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Hiroyuki Nakamura

1

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Kana Yasufuku

2

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Tomohiko Makiyama

3

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Ikiru Matsumoto

4

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Hiromichi Fujino

5

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Toshihiko Murayama

6

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publication date

1 July 2012

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Journal of Cellular Physiology

published in

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volume

227

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issue

7

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page(s)

2847-2855

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Oxidative stress and arachidonic acid mobilization.

cites work

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H2O2 induces a transient multi-phase cell cycle arrest in mouse fibroblasts through modulating cyclin D and p21Cip1 expression

21 January 2018

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Postnatal development of inflammation in a murine model of Niemann-Pick type C disease: immunohistochemical observations of microglia and astroglia

21 January 2018

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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

21 January 2018

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Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis

21 January 2018

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Interactions between neural membrane glycerophospholipid and sphingolipid mediators: a recipe for neural cell survival or suicide

21 January 2018

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Golgi vesiculation induced by cholesterol occurs by a dynamin- and cPLA2-dependent mechanism

21 January 2018

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Cerebellar degeneration in the Niemann-Pick type C mouse

21 January 2018

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Regulatory mechanism and physiological role of cytosolic phospholipase A2

21 January 2018

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Localization of cytosolic phospholipase A2 messenger RNA mainly in neurons in the rat brain

21 January 2018

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Chronic exposure to U18666A is associated with oxidative stress in cultured murine cortical neurons.

21 January 2018

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Decreased membrane fluidity and unsaturated fatty acids in Niemann-Pick disease type C fibroblasts

21 January 2018

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Cytotoxicity induced by inhibition of thioredoxin reductases via multiple signaling pathways: role of cytosolic phospholipase A(2)alpha-dependent and -independent release of arachidonic acid

21 January 2018

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Toll-like receptor 9-stimulated monocyte chemoattractant protein-1 is mediated via JNK-cytosolic phospholipase A2-ROS signaling

21 January 2018

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Suppression of macrophage eicosanoid synthesis by atherogenic lipoproteins is profoundly affected by cholesterol-fatty acyl esterification and the Niemann-Pick C pathway of lipid trafficking

21 January 2018

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Niemann-Pick type C mutations cause lipid traffic jam.

21 January 2018

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Influence of molecular packing and phospholipid type on rates of cholesterol exchange

21 January 2018

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Inhibition of arachidonic acid release and cytosolic phospholipase A2 alpha activity by D-erythro-sphingosine

21 January 2018

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Ceramide-1-phosphate activates cytosolic phospholipase A2alpha directly and by PKC pathway.

21 January 2018

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Modulation of the activity of cytosolic phospholipase A2alpha (cPLA2alpha) by cellular sphingolipids and inhibition of cPLA2alpha by sphingomyelin

21 January 2018

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Identification of HE1 as the second gene of Niemann-Pick C disease

21 January 2018

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Cholesterol, oxidative stress, and Alzheimer's disease: expanding the horizons of pathogenesis

21 January 2018

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Arachidonic acid cytotoxicity: can arachidonic acid be a physiological mediator of cell death?

21 January 2018

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Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease

21 January 2018

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Unique targeting of cytosolic phospholipase A2 to plasma membranes mediated by the NADPH oxidase in phagocytes

21 January 2018

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Beneficial effects of anti-inflammatory therapy in a mouse model of Niemann-Pick disease type C1.

21 January 2018

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Neurofibrillary tangles in Niemann-Pick disease type C.

21 January 2018

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Endosomal accumulation of Toll-like receptor 4 causes constitutive secretion of cytokines and activation of signal transducers and activators of transcription in Niemann-Pick disease type C (NPC) fibroblasts: a potential basis for glial cell activat

21 January 2018

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Accumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transport

21 January 2018

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Roles for cytosolic phospholipase A2alpha as revealed by gene-targeted mice

21 January 2018

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Consequences of NPC1 and NPC2 loss of function in mammalian neurons

21 January 2018

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Apoptosis accompanied by up-regulation of TNF-alpha death pathway genes in the brain of Niemann-Pick type C disease.

21 January 2018

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Inhibition of hydrogen peroxide-induced apoptosis but not arachidonic acid release in GH3 cell by EGF.

21 January 2018

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Development of an assay for the intermembrane transfer of cholesterol by Niemann-Pick C2 protein

21 January 2018

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Phospholipase A2 enzymes

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21 January 2018

Identifiers

DOI

10.1002/JCP.23025

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11 April 2018

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