(Q51768633)

11 April 2018

title

Age-related accumulation of autosomal mutations in solid tissues of the mouse is gender and cell type specific. (English)

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11 April 2018

author

Michael Lasarev

2

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11 April 2018

author name string

Mitchell S Turker

1

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11 April 2018

Lanelle Connolly

3

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11 April 2018

Elizabeth Kasameyer

4

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11 April 2018

Deborah Roessler

5

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11 April 2018

publication date

1 February 2007

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11 April 2018

published in

Aging Cell

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11 April 2018

volume

6

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11 April 2018

issue

1

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11 April 2018

page(s)

73-86

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11 April 2018

Effect of caloric restriction on Hprt lymphocyte mutation in aging rats.

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Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture

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Atm haploinsufficiency does not affect ionizing radiation mutagenesis in solid mouse tissues.

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Aging biology and cancer

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Rapid accumulation of genome rearrangements in liver but not in brain of old mice

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Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine

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Adenine phosphoribosyltransferase-deficient mice develop 2,8-dihydroxyadenine nephrolithiasis

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Spontaneously immortalized cell lines obtained from adult Atm null mice retain sensitivity to ionizing radiation and exhibit a mutational pattern suggestive of oxidative stress

21 January 2018

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Selection against blood cells deficient in hypoxanthine phosphoribosyltransferase (HPRT) in Lesch-Nyhan heterozygotes occurs at the level of multipotent stem cells

21 January 2018

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Tissue-specific time courses of spontaneous mutation frequency and deviations in mutation pattern are observed in middle to late adulthood in Big Blue mice.

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Somatic mutations and ageing.

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A cloning assay for 6-thioguanine resistance provides evidence against certain somatic mutational theories of aging

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Human aging is associated with stochastic somatic mutations of mitochondrial DNA.

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Does premature aging of the mtDNA mutator mouse prove that mtDNA mutations are involved in natural aging?

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What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment?

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Hereditary cancer: two hits revisited

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Cancer and aging: a model for the cancer promoting effects of the aging stroma

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The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations

21 January 2018

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Cell senescence in rat kidneys in vivo increases with growth and age despite lack of telomere shortening.

21 January 2018

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A simple salting out procedure for extracting DNA from human nucleated cells

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Human lymphocytes resistant to 6-thioguanine increase with age.

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Age-associated increase of spontaneous mutant frequency and molecular nature of mutation in newborn and old lacZ-transgenic mouse.

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Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

21 January 2018

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Frequency and types of spontaneous Hprt lymphocyte mutations in Pms2-deficient mice

21 January 2018

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Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice.

21 January 2018

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Somatic cell mutations: can they provide a link between aging and cancer?

21 January 2018

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Autosomal mutation in somatic cells of the mouse

21 January 2018

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Determination of spontaneous loss of heterozygosity mutations in Aprt heterozygous mice

21 January 2018

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DMBA-induced toxic and mutagenic responses vary dramatically between NER-deficient Xpa, Xpc and Csb mice

21 January 2018

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Carcinogen-induced loss of heterozygosity at the Aprt locus in somatic cells of the mouse

21 January 2018

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Chemical carcinogens induce varying patterns of LOH in mouse T-lymphocytes

21 January 2018

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Cancer in the aged. An epidemiologic perspective on treatment issues

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21 January 2018

Identifiers

DOI

1 reference

11 April 2018

1 reference

11 April 2018