(Q51819975)

English

Regulation of HA14-1 mediated oxidative stress, toxic response, and autophagy by curcumin to enhance apoptotic activity in human embryonic kidney cells.

scientific article published on 5 April 2013

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23559532%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Regulation of HA14-1 mediated oxidative stress, toxic response, and autophagy by curcumin to enhance apoptotic activity in human embryonic kidney cells (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23559532%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

apoptotic process

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Chandramani Pathak

4

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28 February 2020

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Kishu Ranjan

1

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28 February 2020

Anupama Sharma

2

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28 February 2020

Avadhesha Surolia

3

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28 February 2020

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5 April 2013

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28 February 2020

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28 February 2020

40

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28 February 2020

1

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28 February 2020

157-169

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28 February 2020

Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal

1 reference

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21 January 2018

A Bcr/Abl-independent, Lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2.

1 reference

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21 January 2018

HA14-1 selectively induces apoptosis in Bcl-2-overexpressing leukemia/lymphoma cells, and enhances cytarabine-induced cell death

1 reference

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21 January 2018

The proteasome inhibitor bortezomib promotes mitochondrial injury and apoptosis induced by the small molecule Bcl-2 inhibitor HA14-1 in multiple myeloma cells

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HA14-1, a small molecule Bcl-2 antagonist, induces apoptosis and modulates action of selected anticancer drugs in follicular lymphoma B cells

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Critical upstream signals of cytochrome C release induced by a novel Bcl-2 inhibitor

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The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death.

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The mitochondrial effects of small organic ligands of BCL-2: sensitization of BCL-2-overexpressing cells to apoptosis by a pyrimidine-2,4,6-trione derivative

1 reference

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21 January 2018

Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer agents

1 reference

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21 January 2018

Ethyl-2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H- chromene-3-carboxylate (HA 14-1), a prototype small-molecule antagonist against antiapoptotic Bcl-2 proteins, decomposes to generate reactive oxygen species that induce apoptosis.

1 reference

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21 January 2018

Reactive oxygen species mediate crosstalk between NF-kappaB and JNK.

1 reference

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21 January 2018

Oxidative stress and apoptosis: impact on cancer therapy.

1 reference

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21 January 2018

Role of protein kinase C delta in curcumin-induced antioxidant response element-mediated gene expression in human monocytes.

1 reference

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21 January 2018

Curcumin reverses breast tumor exosomes mediated immune suppression of NK cell tumor cytotoxicity

1 reference

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21 January 2018

Antioxidant and radical scavenging properties of curcumin

1 reference

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21 January 2018

Curcumin-induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications

1 reference

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21 January 2018

Through metal binding, curcumin protects against lead- and cadmium-induced lipid peroxidation in rat brain homogenates and against lead-induced tissue damage in rat brain.

1 reference

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21 January 2018

Intracellular ROS protection efficiency and free radical-scavenging activity of curcumin

1 reference

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21 January 2018

sHA 14-1, a stable and ROS-free antagonist against anti-apoptotic Bcl-2 proteins, bypasses drug resistances and synergizes cancer therapies in human leukemia cell

1 reference

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21 January 2018

Dietary Supplementation of Curcumin Enhances Antioxidant and Phase II Metabolizing Enzymes in ddY Male Mice: Possible Role in Protection against Chemical Carcinogenesis and Toxicity

1 reference

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21 January 2018

Mechanisms of apoptosis avoidance in cancer.

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21 January 2018

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

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21 January 2018

Apoptotic response to photodynamic therapy versus the Bcl-2 antagonist HA14-1.

1 reference

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21 January 2018

Initiation of apoptosis and autophagy by the Bcl-2 antagonist HA14-1.

1 reference

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21 January 2018

Autophagic and apoptotic mechanisms of curcumin-induced death in K562 cells

1 reference

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21 January 2018

Shooting at survivors: Bcl-2 family members as drug targets for cancer

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21 January 2018

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

1 reference

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21 January 2018

Curcumin mediates time and concentration dependent regulation of redox homeostasis leading to cytotoxicity in macrophage cells

1 reference

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21 January 2018

Emerging Bcl-2 inhibitors for the treatment of cancer

1 reference

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21 January 2018

Life and death decisions: secondary complexes and lipid rafts in TNF receptor family signal transduction

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21 January 2018

Enhancing activity and overcoming chemoresistance in hematologic malignancies with bortezomib: preclinical mechanistic studies

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21 January 2018

Anti-invasive gene expression profile of curcumin in lung adenocarcinoma based on a high throughput microarray analysis.

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21 January 2018

The pathophysiology of mitochondrial cell death

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21 January 2018

Autophagy as a mediator of chemotherapy-induced cell death in cancer

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21 January 2018

The BH3 mimetic HA14-1 enhances 5-fluorouracil-induced autophagy and type II cell death in oesophageal cancer cells

1 reference

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21 January 2018

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