(Q52309402)

25 June 2018

title

The p53 Tumor Suppressor in the Control of Metabolism and Ferroptosis. (English)

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25 June 2018

0 references

6

Maureen E Murphy

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25 June 2018

author name string

Keerthana Gnanapradeepan

1

1 reference

25 June 2018

Subhasree Basu

2

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25 June 2018

Thibaut Barnoud

3

1 reference

25 June 2018

Anna Budina-Kolomets

4

1 reference

25 June 2018

Che-Pei Kung

5

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25 June 2018

publication date

11 April 2018

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25 June 2018

Frontiers in Endocrinology

published in

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25 June 2018

volume

9

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25 June 2018

page(s)

124

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25 June 2018

Creative Commons Attribution 4.0 International

copyright license

start time

11 April 2018

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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p53 as a Regulator of Lipid Metabolism in Cancer

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Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression

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30 June 2018

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An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model

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The P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction

30 June 2018

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Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

30 June 2018

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Glutaminolysis and Transferrin Regulate Ferroptosis

30 June 2018

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Identification of TRIML2, a novel p53 target, that enhances p53 SUMOylation and regulates the transactivation of proapoptotic genes

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Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD

30 June 2018

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Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation.

30 June 2018

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Regulation of ferroptotic cancer cell death by GPX4

30 June 2018

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Tumour-associated mutant p53 drives the Warburg effect

30 June 2018

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30 June 2018

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Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model

30 June 2018

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Regulation of lipid metabolism by p53 - fighting two villains with one sword.

30 June 2018

1 reference

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Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

Ferroptosis: an iron-dependent form of nonapoptotic cell death

30 June 2018

1 reference

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Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

p53, a novel regulator of lipid metabolism pathways.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

Tissue-specific apoptotic effects of the p53 codon 72 polymorphism in a mouse model.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

Hallmarks of Cancer: The Next Generation

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

The codon 72 polymorphism of p53 regulates interaction with NF-{kappa}B and transactivation of genes involved in immunity and inflammation

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

apoB and apobec1, two genes key to lipid metabolism, are transcriptionally regulated by p53.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

Dysregulation of the mevalonate pathway promotes transformation

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

Common tumour p53 mutations in immortalized cells from Hupki mice heterozygous at codon 72.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

TIGAR, a p53-inducible regulator of glycolysis and apoptosis

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

p53 regulates mitochondrial respiration

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

p53 Activation in Adipocytes of Obese Mice

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

Phosphorylation-activity relationships of AMPK and acetyl-CoA carboxylase in muscle

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

Deciphering p53 signaling in tumor suppression.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

Effect of Mutant p53 Proteins on Glycolysis and Mitochondrial Metabolism.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

The p53 codon 72 (Arg72Pro) polymorphism is associated with the degree of insulin resistance in type 2 diabetic subjects: a cross-sectional study

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

Genotypes of p53 codon 72 correlate with age at onset of type 1 diabetes in a sex-specific manner.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

Dysregulation of sterol response element-binding proteins and downstream effectors in prostate cancer during progression to androgen independence

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: a new biomedical research tool.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5904197

13 August 2018

Identifiers

DOI

10.3389/FENDO.2018.00124

1 reference

25 June 2018

PMC publication ID

5904197

1 reference

25 June 2018

PubMed publication ID

29695998

1 reference

25 June 2018