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The role of the p53 tumor suppressor in metabolism and diabetes
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PubMed
review article
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Europe PubMed Central
title
The role of the p53 tumor suppressor in metabolism and diabetes
(English)
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PubMed
author
Maureen Murphy
series ordinal
2
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Europe PubMed Central
PMC publication ID
5148674
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27613337%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 May 2020
author name string
Che-Pei Kung
series ordinal
1
2 references
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Crossref
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Europe PubMed Central
PMC publication ID
5148674
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27613337%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 May 2020
language of work or name
English
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PubMed
publication date
November 2016
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PubMed
published in
Journal of Endocrinology
2 references
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PubMed
stated in
Europe PubMed Central
PMC publication ID
5148674
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27613337%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 May 2020
volume
231
2 references
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PubMed
stated in
Europe PubMed Central
PMC publication ID
5148674
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27613337%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 May 2020
issue
2
2 references
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PubMed
stated in
Europe PubMed Central
PMC publication ID
5148674
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27613337%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 May 2020
page(s)
R61-R75
2 references
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PubMed
stated in
Europe PubMed Central
PMC publication ID
5148674
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27613337%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 May 2020
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The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression
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Enhanced phosphorylation of p53 by ATM in response to DNA damage
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Blinded by the Light: The Growing Complexity of p53
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Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
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p53 and metabolism
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Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD
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Identification of O-GlcNAc modification targets in mouse retinal pericytes: implication of p53 in pathogenesis of diabetic retinopathy
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Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic β-cell function in diabetes
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The MDM2 inhibitor Nutlin-3 attenuates streptozotocin-induced diabetes mellitus and increases serum level of IL-12p40.
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p53 is required for brown adipogenic differentiation and has a protective role against diet-induced obesity
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p53-Dependent regulation of metabolic function through transcriptional activation of pantothenate kinase-1 gene
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Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease
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Microvascular dysfunction is associated with a higher incidence of type 2 diabetes mellitus: a systematic review and meta-analysis
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p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure
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Codon 72 polymorphism (rs1042522) of TP53 is associated with changes in diastolic blood pressure over time
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p53, a novel regulator of lipid metabolism pathways.
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Survival of pancreatic beta cells is partly controlled by a TCF7L2-p53-p53INP1-dependent pathway
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Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect
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The Role of p53 in Metabolic Regulation
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Δ40 Isoform of p53 controls β-cell proliferation and glucose homeostasis in mice.
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Improved diabetic wound healing through topical silencing of p53 is associated with augmented vasculogenic mediators
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GAMT, a p53-inducible modulator of apoptosis, is critical for the adaptive response to nutrient stress
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Absence of p53-dependent apoptosis combined with nonhomologous end-joining deficiency leads to a severe diabetic phenotype in mice
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p53 polymorphisms: cancer implications
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The p53 family and programmed cell death
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p53 family in development
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Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
29 September 2017
Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
29 September 2017
Cyclin-dependent kinase inhibitor, p21WAF1/CIP1, is involved in adipocyte differentiation and hypertrophy, linking to obesity, and insulin resistance.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
29 September 2017
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
29 September 2017
Expression of p53, Bax and Bcl-2 proteins in hepatocytes in non-alcoholic fatty liver disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
29 September 2017
Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
29 September 2017
Obesity, peroxisome proliferator-activated receptor, and atherosclerosis in type 2 diabetes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
29 September 2017
The coordinate regulation of the p53 and mTOR pathways in cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
29 September 2017
Synergistic activation of JNK/SAPK induced by TNF-alpha and IFN-gamma: apoptosis of pancreatic beta-cells via the p53 and ROS pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
29 September 2017
p53 involvement in the pathogenesis of fatty liver disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
29 September 2017
Identification and characterization of polymorphic variations of the ataxia telangiectasia mutated (ATM) gene in childhood Hodgkin disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
29 September 2017
p53 Activation in Adipocytes of Obese Mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
29 September 2017
Mitochondrial functional state in clonal pancreatic beta-cells exposed to free fatty acids
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
29 September 2017
The codon 72 polymorphic variants of p53 have markedly different apoptotic potential
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
29 September 2017
Blood flow and muscle metabolism: a focus on insulin action.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
29 September 2017
Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
29 September 2017
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
29 September 2017
A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
29 September 2017
Glucose transporters and insulin action--implications for insulin resistance and diabetes mellitus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
29 September 2017
p53 is a transcriptional activator of the muscle-specific phosphoglycerate mutase gene and contributes in vivo to the control of its cardiac expression.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
29 September 2017
Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
29 September 2017
Overexpression of Rad inhibits glucose uptake in cultured muscle and fat cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
29 September 2017
Repression of the insulin receptor promoter by the tumor suppressor gene product p53: a possible mechanism for receptor overexpression in breast cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
29 September 2017
Identification of TRIML2, a novel p53 target, that enhances p53 SUMOylation and regulates the transactivation of proapoptotic genes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
2 June 2018
Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
2 June 2018
Exacerbation of diabetes-induced testicular apoptosis by zinc deficiency is most likely associated with oxidative stress, p38 MAPK activation, and p53 activation in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
2 June 2018
Identification of Tcf-4 as a transcriptional target of p53 signalling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
2 June 2018
The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
27 November 2018
Nonalcoholic fatty liver disease: A main driver of insulin resistance or a dangerous liaison?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
27 November 2018
Relationship of p53 accumulation in peripheral tissues of high-fat diet-induced obese rats with decrease in metabolic and oncogenic signaling of insulin.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
27 November 2018
Inhibition of endothelial p53 improves metabolic abnormalities related to dietary obesity.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
27 November 2018
Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in β cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
27 November 2018
p53 promotes the expression of gluconeogenesis-related genes and enhances hepatic glucose production
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
27 November 2018
Growth hormone is necessary for the p53-mediated, obesity-induced insulin resistance in male C57BL/6J x CBA mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
27 November 2018
Ghrelin requires p53 to stimulate lipid storage in fat and liver.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
27 November 2018
The p53 codon 72 (Arg72Pro) polymorphism is associated with the degree of insulin resistance in type 2 diabetic subjects: a cross-sectional study
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
27 November 2018
p53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
27 November 2018
RXR antagonism induces G0/G1 cell cycle arrest and ameliorates obesity by up-regulating the p53-p21$^{\rm{Cip1}}$ pathway in adipocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
27 November 2018
Genotypes of p53 codon 72 correlate with age at onset of type 1 diabetes in a sex-specific manner.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
27 November 2018
The p53 family: guardians of maternal reproduction.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
27 November 2018
Exercise training attenuates oxidative stress and decreases p53 protein content in skeletal muscle of type 2 diabetic Goto-Kakizaki rats.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
27 November 2018
Atorvastatin prevents ischemic limb loss in type 2 diabetes: role of p53.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
27 November 2018
P53 and aging: A fresh look at an old paradigm
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
27 November 2018
Protective role of SIRT1 in diabetic vascular dysfunction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
27 November 2018
Polymorphisms of the ApoE, HSD3B1, IL-1beta and p53 genes are associated with the development of early uremic complications in diabetic patients: results of a DNA resequencing array study
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
27 November 2018
p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
27 November 2018
p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
27 November 2018
p53 and stress in the ER.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148674
retrieved
27 November 2018
Association between polymorphisms in RAPGEF1, TP53, NRF1 and type 2 diabetes in Chinese Han population
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27613337
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
[Association of polymorphous markers Pro72Arg and C(-594)CC OF TP53 gene with diabetic polyneuropathy in patients with type 1 diabetes mellitus living in Moscow]
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27613337
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Diabetes increases p53-mediated apoptosis following ischemia
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27613337
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Comparison of abdominal adiposity and overall obesity in predicting risk of type 2 diabetes among men
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27613337
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A crucial role for adipose tissue p53 in the regulation of insulin resistance
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27613337
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Semaphorin3E-induced inflammation contributes to insulin resistance in dietary obesity
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27613337
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27613337
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Is there a role of p53 codon 72 polymorphism in the susceptibility to type 2 diabetes in overweight subjects? A study in patients with cardiovascular diseases
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27613337
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1530/JOE-16-0324
2 references
stated in
PubMed
stated in
Europe PubMed Central
PMC publication ID
5148674
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27613337%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 May 2020
PMC publication ID
5148674
2 references
stated in
PubMed
stated in
Europe PubMed Central
PMC publication ID
5148674
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27613337%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 May 2020
PubMed publication ID
27613337
2 references
stated in
PubMed
stated in
Europe PubMed Central
PMC publication ID
5148674
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27613337%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 May 2020
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