(Q52827047)

8 May 2018

title

Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts. (English)

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8 May 2018

main subject

cell line

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ataxia telangiectasia

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Kazuhito Naka

1

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8 May 2018

Akira Tachibana

series ordinal

2

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8 May 2018

Kyoji Ikeda

series ordinal

3

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8 May 2018

Noboru Motoyama

series ordinal

4

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8 May 2018

language of work or name

English

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publication date

21 October 2003

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8 May 2018

Journal of Biological Chemistry

published in

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8 May 2018

volume

279

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8 May 2018

issue

3

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8 May 2018

page(s)

2030-2037

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8 May 2018

describes a project that uses

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Putting the stress on senescence

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

The serial cultivation of human diploid cell strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Extension of life-span by introduction of telomerase into normal human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Mediation of c-Myc-induced apoptosis by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Senescence of human fibroblasts induced by oncogenic Raf.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Induction of a senescence-like phenotype in bovine aortic endothelial cells by ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Oxidative stress shortens telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

The genetic defect in ataxia-telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Chromosome end associations, telomeres and telomerase activity in ataxia telangiectasia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Accelerated telomere shortening in ataxia telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

ATM, a central controller of cellular responses to DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Post-translational modifications and activation of p53 by genotoxic stresses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Characterization of ataxia telangiectasia fibroblasts with extended life-span through telomerase expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Establishment of immortal normal and ataxia telangiectasia fibroblast cell lines by introduction of the hTERT gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Induction of ATF3 by ionizing radiation is mediated via a signaling pathway that includes ATM, Nibrin1, stress-induced MAPkinases and ATF-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Mutations of the ATM gene detected in Japanese ataxia-telangiectasia patients: possible preponderance of the two founder mutations 4612del165 and 7883del5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

The Ataxia telangiectasia gene product is required for oxidative stress-induced G1 and G2 checkpoint function in human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Uncoupling the senescent phenotype from telomere shortening in hydrogen peroxide-treated fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

E2F1 and c-Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates MnSOD-mediated ROS elimination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

E2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Mechanism of p38 MAP kinase activation in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

DNA damage foci at dysfunctional telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309457200

21 January 2018

Identifiers

DOI

10.1074/JBC.M309457200

1 reference

8 May 2018

1 reference

8 May 2018